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简介：主要睫的运动障碍(PCD)是源于正常睫的功能的损失的正染色体后退的混乱。症状包括新生的呼吸悲痛，长期的窦炎，bronchiectasis，地点inversus，和不孕。然而，仅仅15联系PCD的基因被识别了迄今为止引起男不孕。由于PCD的基因异质，全面分子的基因测试没被认为照顾的标准。这里，我们在与与男不孕联系的PCD有关的基因因素的鉴定上提供进步的更改，总结内在的分子的机制，并且讨论这些调查结果的临床的含意。这块地里的进一步的研究将为男不孕影响诊断策略，使临床医生能向病人提供通知基因建议，并且帮助为开发直接指向的个性化的药采用治疗的最好的功课。

简介：InordertosolveabottleneckprobleminpowernetworksafetyoperationtheElectrotechnicalResearchInstituteundertheChineseAcademyofSciencehasfinishedadevelopmentworkofprototypehigh-temperaturesuperconductingcurrentlimiterwithindependentintellectualpropertyrightsonthebasisofatheoryadvancedonitsown.Suchalimiterhasovercomedisadvantagesinexistingonesworldwide.

简介：AbstractThe LIM domain only 1 (LMO1) gene belongs to the LMO family of genes that encodes a group of transcriptional cofactors. This group of transcriptional cofactors regulates gene transcription by acting as a key "connector" or "scaffold" in transcription complexes. All LMOs, including LMO1, are important players in the process of tumorigenesis. Unique biological features of LMO1 distinct from other LMO members, such as its tissue-specific expression patterns, interacting proteins, and transcriptional targets, have been increasingly recognized. Studies indicated that LMO1 plays a critical oncogenic role in various types of cancers, including T-cell acute lymphoblastic leukemia, neuroblastoma, gastric cancer, lung cancer, and prostate cancer. The molecular mechanisms underlying such functions of LMO1 have also been investigated, but they are currently far from being fully elucidated. Here, we focus on reviewing the current findings on the role of LMO1 in tumorigenesis, the mechanisms of its oncogenic action, and the mechanisms that drive its aberrant activation in cancers. We also briefly review its roles in the development process and non-cancer diseases. Finally, we discuss the remaining questions and future investigations required for promoting the translation of laboratory findings to clinical applications, including cancer diagnosis and treatment.

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简介：Withpricesformetalresourcessuchasnickelandmolybdenumsoaring,thereisaheightenedsenseofcrisisconcerningresourcescarcity.WhileType304,themostcommonstainlesssteel,offersexcellentcorrosionresistance,itspriceisaffectedsignificantlybythecostofnickelbecauseofits8%nickelcontent.ThestainlesssteelthathasthesamecorrosionresistanceasthatofType304anddoesnotcontainnickelandmolybdenumhasbeenrequired.JFESteelCorporationhasdevelopedanew21%Cr-0.4%Custainlesssteel,theworld’sfirstferriticstainlesssteel,whichoffersequivalentcorrosionresistancetoType304whilecontainingabsolutelynonickelormolybdenum,tworaremetals.Thenewlydevelopedsteelcontains21%chromiumwiththeadditionof0.4%copper.Thedevelopmentofthesteelisbasedonanewdiscoverythatthepassivefilmsofstainlesssteelscouldbestrengthenedbythesynergyeffectofhighchromiumcontentandcopperaddition.Copperadditionenrichesthechromiumcontentinpassivefilmsafterfieldexposure.Newlydeveloped21%Cr-0.4%CustainlesssteelisadoptedformanyapplicationsasasubstitutionforType304,includingcommercialkitchenware,buildingmaterialsandindustrialmachinery.ThesteelisexpectedtobeanewstandardofaferriticstainlesssteelasasubstitutionforType304.

简介：AbstractThe pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented social and economic disruption. Many nucleic acid testing (NAT) laboratories in China have been established to control the epidemic better. This proficiency testing (PT) aims to evaluate the participants’ performance in qualitative and quantitative SARS-CoV-2 NAT and to explore the factors that contribute to differences in detection capabilities. Two different concentrations of RNA samples (A, B) were used for quantitative PT. Pseudovirus samples D, E (different concentrations) and negative sample (F) were used for qualitative PT. 50 data sets were reported for qualitative PT, of which 74.00% were entirely correct for all samples. Forty-two laboratories participated in the quantitative PT. 37 submitted all gene results, of which only 56.76% were satisfactory. For qualitative detection, it is suggested that laboratories should strengthen personnel training, select qualified detection kits, and reduce cross-contamination to improve detection accuracy. For quantitative detection, the results of the reverse transcription digital PCR (RT-dPCR) method were more comparable and reliable than those of reverse transcription quantitative PCR (RT-qPCR). The copy number concentration of ORF1ab and N in samples A and B scattered in 85, 223, 50, and 106 folds, respectively. The differences in the quantitative result of RT-qPCR was mainly caused by the non-standard use of reference materials and the lack of personnel operating skills. Comparing the satisfaction of participants participating in both quantitative and qualitative proficiency testing, 95.65% of the laboratories with satisfactory quantitative results also judged the qualitative results correctly, while 85.71% of the laboratories with unsatisfactory quantitative results were also unsatisfied with their qualitative judgments. Therefore, the quantitative ability is the basis of qualitative judgment. Overall, participants from hospitals reported more satisfactory results than those from enterprises and universities. Therefore, surveillance, daily qualitiy control and standardized operating procedures should be strengthened to improve the capability of SARS-CoV-2 NAT.

简介：AbstractBackground:Reduced application of percutaneous coronary intervention (PCI) is associated with higher mortality rates after ST-segment elevation myocardial infarction (STEMI). We aimed to evaluate potential factors contributing to the refusal of PCI in STEMI patients in China.Methods:We studied 957 patients diagnosed with STEMI in the emergency departments (EDs) of six public hospitals in China. The differences in baseline characteristics and 30-day outcome were investigated between patients who refused PCI and those who underwent PCI. Multivariable logistic regression was used to evaluate the potential factors associated with refusing PCI.Results:The potential factors contributing to refusing PCI were older than 65 years (odds ratio [OR] 2.66, 95% confidence interval [CI] 1.56-4.52, P < 0.001), low body mass index (BMI) (OR 0.91, 95% CI 0.84-0.98, P = 0.013), not being married (OR 0.29, 95% CI 0.17-0.49, P < 0.001), history of myocardial infarction (MI) (OR 2.59, 95% CI 1.33-5.04, P = 0.005), higher heart rate (HR) (OR 1.02, 95% CI 1.01-1.03, P = 0.002), cardiac shock in the ED (OR 5.03, 95% CI 1.48-17.08, P = 0.010), pre-hospital delay (>12 h) (OR 3.31, 95% CI 1.83-6.02, P < 0.001) and not being hospitalized in a tertiary hospital (OR 0.45, 95% CI 0.27-0.75, P = 0.002). Compared to men, women were older, were less often married, had a lower BMI and were less often hospitalized in tertiary hospitals.Conclusions:Patients who were older, had lower economic or social status, and had poorer health status were more likely to refuse PCI after STEMI. There was a sex difference in the potential predictors of refusing PCI. Targeted efforts should be made to improve the acceptance of PCI among patients with STEMI in China.

简介：AbstractPurpose:Road traffic accidents (RTAs) are a public health issue and cost a lot to individuals, families, communities and nations. Trauma care systems in India are at a nascent stage of development. There is gross disparity between trauma services available in various parts of the country. Rural area in India has inefficient services for trauma care, due to the varied topography, financial constraints, and lack of appropriate health infrastructure. The present study is to study the trends of occurrence of RTA cases by month, week and time of accident occurrence as well as to research the types of vehicle involved in accidents and other various risk factors related to them.Methods:During 1st January 2017 to 31st December 2017, a hospital-based and cross-sectional study of RTA victims was conducted. The patients were admitted in emergency department of Uttar Pradesh University of Medical Sciences, Saifai, Etawah, when stabilized, they were shifted to the orthopaedics and surgery ward.Results:In the study, 654 road accident victims were included, of which the majority were males (77.5%) and the most of them belonged to rural (67%). RTA victims according to the month of occurrence majority were found in January (12.5%) and evening was time of a day with maximum accidents (32.1%). Mortality cases of RTA victims based on type of road user and it shows decreasing trend of mortality of motor-cyclists (54.2%) followed by pedestrian (25.1%).Conclusion:There should be control over people driving vehicles under the influence of alcohol and drivers over-speeding and rash driving on urban roads as well as rural village roads.

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