简介:Intoday'sInternetcomputingworld,illegalactivitiesbycrackersposeaseriousthreattocomputersecurity.Itiswellknownthatcomputerviruses,Trojanhorsesandotherintrusiveprogramsmaycausesevereandoftencatastrophicconsequences.Thispaperproposesanovelsecurecomputerarchitecturebasedonsecurity-code.Everyinstruction/datawordisaddedwithasecurity-codedenotingitssecuritylevel.Externalprogramsanddataareautomaticallyaddedwithsecurity-codebyhardwarewhenenteringacomputersystem.Instructionwithlowersecurity-codecannotrunorprocessinstruction/datawithhighersecuritylevel.Security-codecannotbemodifiedbynormalinstruction.Withminorhardwareoverhead,thenewarchitecturecaneffectivelyprotectthemaincomputersystemfromdestructionortheftbyintrusiveprogramssuchascomputerviruses.FormostPCsystems,itincludesanincreaseofword-lengthby1bitonregisters,thememoryandtheharddisk.
简介:Itisproposedthatsomepossiblemacroseismicepicenterscanbedeterminedquicklyfromtherelationshipthatthemicroseismicepicenterslocatedbyinstrumentsbearwithfaults.Basedontheseso-calledmacroseismicepicenters,wecanmakefastseismichazardestimationafterashockbyuseoftheempiricaldistributionmodelofseismicintensity.Incomparisonwiththemethodthatusesthemicroseismicepicentersdirectly,thisapproachcanincreasetheprecisionoffastseismichazardestimation.Statisticalanalysisof133mainearthquakesinChinawasmade.Theresultshowsthatthedeviationdistancebetweenthemicroseismicepicenterandmacroseismicepicenterfallswithintherangeof35kmfor88%earthquakesofthetotalandwithintherangeof35to75kmfortheremainingones.Then,wecantaketheareathathasthemicroseismicepicenterasitscenterandis35kminradiusastheareaforemphaticanalysis,andtaketheareawithin75kmaroundthemicroseismicepicenterastheareaforgeneralanalysis.Therelationbetweenthe66earthquakecasesontheN-SSeismicBeltinChinaandthespatialdistributioncharacteristicsoffaultsandtheresultsoffocalmechanismsolutionwereanalyzedindetail.Weknowfromtheanalysisthattheerrorofinstrumentalepicenterdeterminationisnottheonlyfactorthatgiveseffectstothedeviationofthemacroseismicepicenter.Inadditiontoit,thefaultsize,faultdistribution,faultactivity,faultintersectiontypes,earthquakemagnitude,etc.arealsomainaffectingfactors.Bysortingout,processingandanalyzingtheseaffectingfactors,theprincipleandproceduresforquicklydeterminingthepossiblepositionofthemacroseismicepicenterweresetup.Takingtheseasabasisandestablishinganationwidedatabaseoffaultsthatcontainsrelevantfactors,itispossibletoapplythismethodinpracticalfastestimationofseismichazard.
简介:Thecomplexityofacancer,suchascellheterogeneity,andtheexistenceofhypoxia,stromalcellsandstemcellshaspresent,theuseofconventionaltherapies,suchaschemo/radiotherapyislimited,andonlytherapiesthataresofarpreventedsuccessfuldevelopmentandtreatmentofpatientssufferingfromthelaterstagesofcancers.Atfocusedonutilizingthepatient'simmuneresponsetocombatagainstthediseaseappeartobethemostreliableandpromising.Twodecadesago,cytokineswerediscoveredtobeabletoactivatetheimnunesystemsandmountananti-tumourresponse.Then,dendriticcellswerehailedasthemostsignificantregulatorsofimmunityandareemployedinavarietyofcancermanagementschemes.Thisreviewintroducescurrentdevelopmentinthefield,focusingoncombinationofthecomponentsoftherapidlygrowingfieldsofimmunotherapyandgenetransfer/therapy,providingusefulandsignificantdetailedinformationforreadersofcellularandmolecularimmunology.Cellular&MolecularImmunology.