简介：Glucocorticoids在前列腺癌症的治疗被使用了减缓疾病前进，改进疼痛控制并且抵消chemo-和神经质的治疗的副作用。然而，他们可以也有潜力经由变异的雄激素受体或glucocorticoid受体(GR)驾驶前列腺癌症生长。在这评论，我们在前列腺癌症的治疗检验glucocorticoids的历史、当代的使用，考察他们可以由禁止或开车前列腺癌症生长的潜在的机制，并且描述定义他们对前列腺癌症的生物学的贡献的潜在的工具。

简介：AbstractObjective:The study objective was to investigate whether endogenous glucocorticoids directly impact the functions and proliferation/apoptosis of ovarian granulosa cells.Methods:Primary rat ovarian granulosa cells were cultured and treated with graded concentrations of corticosterone either alone or in the presence of the indicated drugs. After 48 h of treatment, the cells and growth media were collected to measure intracellular and extracellular progesterone/estradiol concentrations, and steroid secretion ratios were obtained by parameter calculation. The number of granulosa cells was determined by Cell Counting Kit-8. To determine the impact on cell numbers, granulosa cell proliferation was detected using the BrdU incorporation method and cell apoptosis was detected by flow cytometry.Results:First, high corticosterone concentrations significantly stimulated progesterone synthesis/secretion and inhibited estradiol synthesis in cultured granulosa cells. Second, accompanied by follicle-stimulating hormone, high corticosterone concentrations promoted progesterone synthesis/release and estradiol release. Last, high corticosterone concentrations increased the cell number and suppressed apoptosis but did not induce cell proliferation.Conclusions:These indicate that high glucocorticoid concentrations may play luteotropic roles in the functions and number of corpora lutea.

简介：作为一个内部应用的反煽动性的代理人，Escin广泛地在从损伤或操作导致诊所的发炎和浮肿的治疗被使用了。然而，它皮肤的发炎和浮肿上的外部使用的效果仍然保持未经勘探。在现在的学习，反煽动性并且escin的外部使用的anti-edematous效果在老鼠，在老鼠胀大的导致paraxylene的耳朵，和棉花在导致carrageenan的爪浮肿和导致组织安的毛状的渗透被学习在老鼠的导致小团的granuloma。前列腺素E2(PGE2)上的escin胶化的外部使用的效果，肿瘤坏死因素--(TNF-)，并且interleukin-1(IL-1)被ELISA决定。反煽动性的机制被与西方的弄污和实时PCR分析检测glucocorticoid受体(GR)的表示探索，与原子factor-B(NF-B)的进一步的探索，p38激活mitogen的蛋白质kinase(P38MAPK)和使活跃之物protein-1(AP-1)表情。我们证明escin的外部使用证明在不同动物模型的尖锐、长期的发炎上的重要反煽动性的效果和它的反煽动性的效果可能与PGE2，TNF-，和IL-1的下面规定有关。结果也证明escin由支持GR的表示施加了它的反煽动性的效果，与是的可能的机制象NF-B和AP-1那样的GR相关的发信号的分子的表情的抑制。

简介：AIMTo评估联合反脉管的endothelial生长的功效和安全因素(VEGF)代理人，口头的glucocorticoid，和为有斑点的浮肿的激光光致疑结治疗(我)对.METHODSThis学习包括了的网膜的静脉吸藏(RVO)第二等16个病人与的16只眼睛联系RVO我。病人们开始与口头的泼尼松和一个intravitrealanti-VEGF代理人被对待。二个星期以后，病人们经历了标准激光光致疑结。改正最好的视觉尖酸(BCVA)，中央网膜的厚度(CRT)，和网膜的容器氧化在收到的12mo.RESULTSPatients上被检验1.43