简介：DataontheincidenceofblindnessinLithuaniaareavailable.WeanalysedcausesoflegalblindnessinLithuania(population3.488million)inordertohelpfillinthisgap.Methods:Population-basedinvestigationontheincidenceoflegalblindness(visualacuitylessthan1/50)basedonmaterialsfromthesocialservices.Age-dependentblindnessincidencesweremod-

简介：AbstractPurpose:The use of tourniquet in orthopedic surgery facilitates operation by establishing a bloodless surgical field. However, many complications following the use of tourniquets have been reported. Tourniquet pain is the most common complication. This study aimed to find the actual incidence of pain associated with tourniquet use in orthopedic surgery and the various factors.Methods:It is a prospective observational study conducted on 132 consecutive cases. Patients aged 18-70 years with musculoskeletal problems of the forearm and leg requiring surgery were included in the study. Patients with open injuries or contraindications such as diabetes mellitus, compromised circulatory states, neurological deficit, compartment syndrome and unable to give informed consent were excluded. The parameters assessed included duration of tourniquet use, tourniquet pressure, type of anesthesia, any interval release of the tourniquet and reapplication after a reperfusion period, whether upper or lower limb surgery, severity of tourniquet pain, timing of tourniquet release and complications. Chi-square and non-parametric Mann-Whitney U test were used for data analysis.Results:In upper limb surgeries, if duration of surgery was less than 60 min, 14 (51.8%) cases experienced tourniquet pain and 13 (48.1%) had no pain, and if duration of surgery was more than 60 min, 24 (60.0%) had pain and 16 (40.0%) experienced no pain. In lower limb surgeries if duration of surgery was less than 60 min, 2 (7.7%) experienced pain and 24 (92.3%) had no pain, and if duration of surgery was more than 60 min, 14 (35.8%) experienced pain and 25 (64.8%) had no pain. Degree of tourniquet pain increases with the duration of surgery. Statistically, there was significant association between tourniquet inflation time and tourniquet pain in both upper and lower limbs (p = 0.034 and 0.024, respectively)Conclusion:Incidence of tourniquet pain was in direct proportion to the duration of tourniquet use and was higher in cases with regional anesthesia. Other risk factors assessed including tourniquet pressure, upper or lower limb surgery, tourniquet release time and interval had no significant contribution to the incidence or severity of tourniquet pain.

简介：当代的系统成熟评价途径没能提供导致增加的程序费用和发展风险的柔韧的量的系统评估。标准评价度量标准例如技术愿意层次(TRL)，足够地不评估逐渐地复杂的系统。系统愿意水平(SRL)是为一个特别系统的部件和连接是TRL和集成愿意水平(中断请求线)值的一个数学函数的一个最新发达的系统开发度量标准。因为对可以导致不精密的系统愿意评价的SRL数学操作的担心，SRL接受被妨碍了。这些不精密的系统愿意评价被称为愿意颠倒。用发生矩阵的一个新SRL计算方法被建议减轻这些数学担心。SRL愿意颠倒的存在越过几种系统配置为四个SRL计算方法被建模。逻辑回归分析证明建议发生矩阵SRL(IMSRL)方法比在文学建议的另外的途径有愿意颠倒的减少的存在。可行SRL方法将由设计专业人员的系统促进更大的SRL采纳并且将支持系统发展风险减小目标。

简介：Objective:Population-basedcancerregistrationdatain2012fromallavailablecancerregistriesinHenanprovincewerecollectedbyHenanOfficeforCancerResearchandControl.ThenumbersofnewcancercasesandcancerdeathsinHenanprovincewithcompiledcancerincidenceandmortalityrateswereestimated.Methods:In2015,allregistries'datainHenanprovincewerequalifiedforthenationalcancerregistryannualreportin2012.Thepooleddatawerestratifiedbyarea(urban/rural),gender,agegroup(0,1-4,5-9,10-14,…,85+)andcancertype.Newcancercasesanddeathswereestimatedusingage-specificratesandcorrespondingpopulationofHenanprovincein2012.TheChinesecensusdatain2000andSegi'spopulationwereappliedforage-standardizedrates.Alltherateswereexpressedper100,000person-years.Results:Qualified19cancerregistries(4urbanand15ruralregistries)covered16,082,688populationsofHenanprovincein2012.Thepercentageofcaseswithmorphologicallyverified(MV%)anddeathcertificateonlycases(DCO%)were69.84%and2.30%,respectively,andthemortalitytoincidencerateratio(M/I)was0.64.Itwasestimatedthattherewere248,510newcancercasesand158,630cancerdeathsinHenanprovincein2012.Theincidenceratewas266.17/100,000(288.61/100,000inmalesand241.86/100,000infemales),theage-standardizedincidenceratesbyChinesestandardpopulation(ASIRC)andbyworldstandardpopulation(ASIRW)were208.95/100,000and206.41/100,000withthecumulativeincidencerate(0-74yearsold)of24.30%.Thecrudeincidencerateinurbanareaswashigherthanthatinruralareas.However,afteradjustedbyage,thecancerincidencerateinruralwashigherthanthatinurbanareas.ThecrudemortalityofallcancersinHenanprovincewas169.90/100,000(201.23/100,000inmalesand135.95/100,000infemales).Theage-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were131.20/100,000and130.80/100,000,respect

简介：Objective:Population-basedcancerregistrationdatain2012fromallavailablecancerregistriesinGansuprovincewerecollectedbytheCentralCancerRegistryofGansu.ThenumbersofnewcancercasesandcancerdeathsinGansuprovincewithcompiledcancerincidenceandmortalityrateswereestimated.Methods:In2015,datafrom7registriesinGansuprovincewerequalified.Thepooleddatawerestratifiedbyarea(urban/rural),gender,agegroup(0,1-4,5-9,10-14,…,85+)andcancertype.Newcancercasesanddeathswereestimatedusingage-specificratesandcorrespondingpopulationofGansuprovincein2012.TheChinesecensusdatain2000andSegi'spopulationwereappliedforage-standardizedrates.Alltherateswereexpressedper100,000person-years.Results:Qualified7cancerregistries(3urbanand4ruralregistries)covered2,956,560populationsofGansuprovincein2012.Thepercentageofcasesmorphologicallyverified(MV%)anddeathcertificate-onlycases(DCO%)were72.41%and1.65%,respectively,andthemortalitytoincidencerateratio(M/I)was0.63.Itwasestimatedthattherewere575,600newcancercasesand331,300cancerdeathsinGansuprovincein2012.Theincidenceratewas223.29/100,000(244.14/100,000inmalesand201.50/100,000infemales),theage-standardizedincidenceratesbyChinesestandardpopulation(ASIRC)andbyworldstandardpopulation(ASIRW)were208.95/100,000and206.41/100,000withthecumulativeincidencerate(0-74yearsold)of22.49%.Thecrudeincidencerateinurbanareaswasequaltothatinruralareas.However,afteradjustedbyage,thecancerincidencerateinurbanwasthesameasthatofruralareas.ThecrudemortalityinGansuprovincewas128.54/100,000(135.04/100,000inmalesand124.43/100,000infemales),theage-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were109.54/100,000and108.44/100,000,respectively,andthecumulativemortalityrate(0-74yearsold)was12.91%.Thecrudecancer

简介：Objective:Population-basedcancerregistrationdatain2012fromallavailablecancerregistriesinShandongprovincewerecollectedbyShandongCenterforDiseaseControlandPrevention(SDCDC).SDCDCestimatedthenumbersofnewcancercasesandcancerdeathsinShandongprovincewithcompiledcancerincidenceandmortalityrates.Methods:In2015,therewere21cancerregistriessubmitteddataofcancerincidenceanddeathsoccurredin2012.AllthedatawerecheckedandevaluatedbasedontheNationalCentralCancerRegistry(NCCR)criteriaofdataquality.Qualifieddatafrom15registrieswereusedforcancerstatisticsanalysisasprovincialestimation.Thepooleddatawerestratifiedbyarea(urban/rural),gender,agegroup(0,1-4,5-9,10-14,…,85+years)andcancertype.Newcancercasesanddeathswereestimatedusingage-specificratesandcorrespondingprovincialpopulationin2012.TheChinesecensusdatain2000andSegi'spopulationwereappliedforage-standardizedrates.Alltherateswereexpressedper100,000person-year.Results:Qualified15cancerregistries(4urbanand11ruralregistries)covered17,189,988populations(7,486,039inurbanand9,703,949inruralareas).Thepercentageofcasesmorphologicallyverified(MV%)anddeathcertificate-onlycases(DCO%)were66.12%and2.93%,respectively,andthemortalitytoincidencerateratio(M/I)was0.60.Atotalof253,060newcancercasesand157,750cancerdeathswereestimatedinShandongprovincein2012.Theincidenceratewas263.86/100,000(303.29/100,000inmales,223.23/100,000infemales),theage-standardizedincidenceratesbyChinesestandardpopulation(ASIRC)andbyworldstandardpopulation(ASIRW)were192.42/100,000and189.50/100,000withthecumulativeincidencerate(0-74yearsold)of22.07%.Thecancerincidence,ASIRCandASIRWinurbanareaswere267.64/100,000,195.27/100,000and192.02/100,000comparedto262.32/100,000,191.26/100,000and188.48/100,000inruralareas,respectively.Thecancermortalitywas164.47/100,

简介：Objective:Toestimatethecancerincidenceandmortalityin2012inGuangdongprovincebyanalyzingthecancerdataofselectedpopulation-basedcancerregistriesinGuangdongprovincein2012.Methods:Eightofninepopulation-basedcancerregistriessubmittedcancerdatatotheGuangdongProvincialCentreforDiseaseControlandPrevention(GuangdongCDC),whosedatametthedataqualitycriteriawereincludedforanalysis.Thestatisticsofselectedregistries,stratifiedbyareas,gender,ageandcancertypes,wereusedtoestimatethecancerincidenceandmortalityin2012inGuangdongprovinceaccordingtothepopulationdatainGuangdongprovince.Segi'spopulationandthenationalcensuspopulationin2000wereusedforcalculatingtheage-standardizedrates(ASR).Results:Atotalof15,084,942people,accountedfor17.47%ofallpopulationinGuangdongprovince,werecoveredin8selectedpopulation-basedcancerregistriesin2012.Thepercentageofcasesmorphologicallyverified(MV%)andthepercentageofdeathcertificate-onlycases(DCO%)were72.84%and0.87%,respectively,andthemortality/incidence(M/I)ratiowas0.56.Itwasestimatedthattherewere211,300newcancercasesand117,300cancerdeaths.Theincidencecruderate(CR),theASRbyChinesestandardpopulation(ASRC)andbyworldstandardpopulation(ASRW),andtheaccumulatedrate(AR)(0-74years)were250.20/100,000(265.39/100,000inmales,234.29/100,000infemales),207.04/100,000,201.34/100,000and22.91%,respectively,inGuangdongprovincein2012.TheincidenceCRandASRCwere267.25/100,000and221.43/100,000inurbanareas,and215.51/100,000and178.77/100,000inruralareas,respectively.ThedeathCR,ASRC,ASRWandAR(0-74years)were148.44/100,000(190.95/100,000inmales,105.06/100,000infemales),103.73/100,000,102.44/100,000and11.68%,respectively,inGuangdongprovincein2012.ThedeathCRandASRCwere164.57/100,000and105.46/100,000inurbanareas,and124.63/100,000and99.97/100,000inruralareas,respectivel

简介：在这篇文章，我们在场有浸透的发生的一个肝炎B流行模型。确定、随机的系统的动态行为被学习。到这个目的，我们首先建立确定的模型的平衡的本地、全球的稳定性条件。由构造合适的随机的Lyapunov功能，第二，为肝炎B的各态历经的静止分发以及扑灭的存在的足够的条件被获得。

简介：LikeelsewhereinChina,eastChina'sZhejiangprovinceisseeingarapidincreaseinAIDSinfection.ByNovember22,2004,theprovincehadcumulativelyreported811HIVcases.Theactualnumberofcarriers,expertssay,ishigherthanthereportedone.

简介：Objective:ThisstudyestimatesthenumbersofnewcancercasesandcancerdeathsinHebeiprovinceusingincidenceandmortalitydatafrom9population-basedcancerregistriesin2012.Methods:Thedataofnewdiagnosedcancercasesandcancerdeathsin2012werecollectedfrom9population-basedcancerregistriesofHebeiprovincein2015.AllthedatamettheNationalCentralCancerRegistryofChina(NCCR)criteriaofdataquality.Thepooleddataanalysiswasstratifiedbyareas(urban/rural),gender,agegroup(0,1-4,5-9,10-14,…,85+)andcancertype.NewcancercasesanddeathsinHebeiprovincewereestimatedusingage-specificratesandcorrespondingprovincialpopulationin2012.The10mostcommoncancersindifferentgroupsandthecumulativerateswerecalculated.Chinesepopulationcensusin2000andSegi'spopulationwereusedforage-standardizedincidence/mortalityrates.Results:Allcancerregistriescovered4,986,847populations,6.84%ofHebeiprovincialpopulation(2,098,547inurbanand2,888,300inruralareas).Thepercentageofcasesmorphologicallyverified(MV%)anddeathcertificate-onlycases(DCO%)were76.40%and4.72%,respectively.Themortalitytoincidencerateratio(M/I)was0.64.In2012,itisestimatedthattherewereabout187,900newdiagnosedcancercasesand119,800cancerdeathsinHebeiprovince.Theincidencerateofcancerwas258.12/100,000(275.75/100,000inmales,239.78/100,000infemales),andtheage-standardizedincidenceratesbyChinesestandardpopulation(ASIRC)andbyworldstandardpopulation(ASIRW)were210.65/100,000and208.50/100,000,withthecumulativeincidencerates(0-74yearsold)of24.46%.ThecancerincidenceandASIRCwere256.99/100,000and211.32/100,000inurbanareasand258.94/100,000and209.99/100,000inruralareas,respectively.Thecancermortalityratewas164.63/100,000(201.85/100,000inmales,125.92/100,000infemales).AgestandardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)w

简介：Objective:ToprovideanoverviewoftheincidenceandmortalityoffemalebreastcancerforcountriesintheAsia-Pacificregion.Methods:Statisticalinformationaboutbreastcancerwasobtainedfrompubliclyavailablecancerregistryandmortalitydatabases(suchasGLOBOCAN),andsupplementedwithdatarequestedfromindividualcancerregistries.Ratesweredirectlyage-standardisedtotheSegiWorldStandardpopulationandtrendswereanalysedusingjoinpointmodels.Results:Breastcancerwasthemostcommontypeofcanceramongfemalesintheregion,accountingfor18%ofallcasesin2012,andwasthefourthmostcommoncauseofcancer-relateddeaths(9%).AlthoughincidenceratesremainmuchhigherinNewZealandandAustralia,rapidrisesinrecentyearswereobservedinseveralAsiancountries.Largeincreasesinbreastcancermortalityratesalsooccurredinmanyareas,particularlyMalaysiaandThailand,incontrasttostabilisingtrendsinHongKongandSingapore,whiledecreaseshavebeenrecordedinAustraliaandNewZealand.Mortalitytrendstendedtobemorefavourableforwomenagedunder50comparedtothosewhowere50yearsorolder.Conclusion:ItisanticipatedthatincidenceratesofbreastcancerindevelopingcountriesthroughouttheAsia-Pacificregionwillcontinuetoincrease.Earlydetectionandaccesstooptimaltreatmentarethekeystoreducingbreastcancerrelatedmortality,butculturalandeconomicobstaclespersist.Consequently,thechallengeistocustomisebreastcancercontrolinitiativestotheparticularneedsofeachcountrytoensurethebestpossibleoutcomes.

简介：

简介：瞄准：在糖尿病的病人调查倒流食道炎(RE)和Hpylori感染的发生。方法：RE和Hpylori感染的发生与糖尿病在85个病人被调查，结果与控制相比。结果：在糖尿病的病人的RE的发生是17.6%。尽管这趋于在糖尿病的病人更高，有没有统计上在糖尿病的病人和控制之间的有效差量。在糖尿病的病人的Hpylori感染的发生是53.7%，但是不，统计上，有效差量在Hpylori感染的发生在糖尿病的病人和控制之间被看见。结论：没有有效差量能在RE和Hpylori感染的发生在糖尿病的病人和控制之间被看见。

简介：BymeansoflimittheoryandFonda'stheorem,anSEISepidemicmodelwithconstantrecruitmentandthedisease-relatedrateisconsidered.Theincidencetermisofthenonlinearform,andthebasicreproductionnumberisfound.Ifthebasicreproductionnumberislessthanone,thereexistsonlythedisease-freeequilibrium,whichisgloballyasymptoticallystable,andthediseasediesouteventually.Ifthebasicreproductionnumberisgreaterthanone,besidestheunstabledisease-freeequilibrium,thereexistsalsoauniqueendemicequilibrium,whichislocallyasymptoticallystable,andthediseaseisuniformlypersistent.

简介：Objective:ToanalyzetheincidenceandmortalityratesoflungcancerinChinafrom2008to2012.Methods:IncidentanddeathcasesoflungcancerwereretrievedfromtheNationalCentralCancerRegistry(NCCR)databasecollectingfrom135cancerregistriesinChinaduring2008-2012.Thecrudeincidenceandmortalityratesoflungcancerwerecalculatedbyarea(urban/rural),region(eastern,middle,western),genderandagegroup(0,1-4,5-9,…,85+).Chinacensusin2000andSegi’sworldpopulationwereappliedforagestandardizedrates.JoinPoint(Version4.5.0.1)modelwasusedfortimetrendanalysis.Results:Thecrudeincidencerateoflungcancerwas54.66/100,000whichrankedthefirstinoverallcancers.Theage-standardizedincidenceratesbyChinapopulation(ASIRC)andbyWorldpopulation(ASIRW)were35.13/100,000and34.86/100,000,respectively.ThecrudemortalityoflungcancerinChinawas45.60/100,000anditwasthefirstcauseofcancer-relateddeathinoverallcancers.Theage-standardizedmortalityratesbyChinesestandardpopulation(ASMRC)andbyworldstandardpopulation(ASMRW)were28.57/100,000and28.22/100,000,respectively.Incidenceandmortalityratesoflungcancerwerehigherinmalesthaninfemalesandhigherinurbanareasthaninruralareas.Easternareashadthehighestincidenceandmortalityratesfollowedbymiddleandwesternareas.Incidenceandmortalityratesoflungcancerretainedlowlevelinagegroupsbefore40yearsoldbutincreasedgreatlyafterandpeakedinagegroupof80-84.During2003-2012,thetemporaltrendoftheincidencerateoflungcancerinbothsexesinChinawasgeneralstable(P<0.05).Thelungcancerincidencerateincreasedby0.71%peryearinfemales(P<0.05)and2.26%peryearinruralareas(P<0.05).Themortalityrateoflungcancerdecreasedslightlyannuallyduring2003-2012inChina(P>0.05).Inurbanareas,itdeclinedby0.76%peryear(P<0.05),butroseby2.09%peryear(P<0.05)inruralareas.Conclusions:Appropriatetargetedprevention,earlydetectionandtreatment

简介：Objective:LivercancerisoneofthemostcommoncancersandmajorcauseofcancerdeathsinChina,whichaccountsforover50%ofnewcasesanddeathsworldwide.Thesystematiclivercancerstatisticsincludingofprojectionthrough2030couldprovidevaluableinformationforpreventionandcontrolstrategiesinChina,andexperienceforothercountries.Methods:TheburdenoflivercancerinChinain2014wasestimatedusing339cancerregistries’dataselectedfromChineseNationalCancerCenter(NCC).Incidentcasesof22cancerregistrieswereappliedfortemporaltrendsfrom2000to2014.Theburdenoflivercancerthrough2030wasprojectedusingage-period-cohortmodel.Results:About364,800newcasesoflivercancer(268,900malesand95,900females)occurredinChina,andabout318,800livercancerdeaths(233,500malesand85,300females)in2014.WesternregionsofChinahadthehighestincidenceandmortalityrates.Incidenceandmortalityratesdecreasedbyabout2.3%and2.6%peryearduringtheperiodof2000-2014,respectively,andwoulddecreasebymorethan44%between2014and2030inChina.Theyounggeneration,particularlyforthoseagedunder40years,showedafasterdowntrend.Conclusions:Basedontheanalysis,incidenceandmortalityratesoflivercancerareexpectedtodecreasethrough2030,buttheburdenoflivercancerisstillseriousinChina,especiallyinruralandwesternareas.MostcasesoflivercancerinChinacanbepreventedthroughvaccinationandmorepreventioneffortsshouldbefocusedonhighriskgroups.

简介：BasedonLucovskyequation,theresponsesolutionof1-Dpositionsensitivedetector(PSD)isgivenundertheconditionofparallellightobliqueincidenceandGaussianbeamobliqueincidence,andtheresponsecharacteristicsareanalyzedbynumericalcalculation.Therelationbetweenobliqueincidentangleandoutputcurrentisintroducedandillustrated.

简介：ＡＦＡＭＩＬＩＡＬ４６ＸＹＧＯＮＡＤＡＬＤＹＳＧＥＮＥＳＩＳＡＮＤＨＩＧＨＩＮＣＩＤＥＮＣＥＯＦＥＭＢＲＹＯＮＩＣＧＯＮＡＤＡＬＴＵＭＯＲＳＥｈＺｈｅｎｇ；鄂征；ＬｉｕＷｅｉｌｉ；刘伟莉（ＤｅｐａｒｔｍｅｎｔｏｆＣｙｔｏｇｅｎｅｔｉｃｓ，Ｂｅｉｊｉｎ...

简介：瞄准：调查怎么在老鼠orthotopic肝移植减少胆汁的复杂并发症的发生。方法：165只男Wistar老鼠的一个总数随机被划分成三个组：组A，有修改二手铐的技术的orthotropic肝移植；组B，没有移植，胆汁管被切并且重建；并且组织C，仅仅剖腹术被执行。基于为胆汁的重建使用的途径，组A被划分成二亚群:A1(n=30)，管管重建，和A2(n=30)，管十二指肠重建。在胆汁管复杂并发症上学习动脉重建的影响，组B被划分成四亚群：B1(n=10)，有肝的动脉结扎的管管重建，B2(n=10)，没有肝的动脉结扎的管管重建，B3(n=10)，有肝的动脉结扎的管十二指肠重建，和B4(n=10)，没有肝的动脉结扎的管十二指肠重建。样品被收获在操作以后或在重要胆汁的复杂并发症被发现的时间的14d。结果：在组A，anhepatic阶段是13.7??€?‥吗？？

简介：AbstractBackground:Ectopic pregnancy (EP) is a common complication in women undergoing assisted reproductive treatment, but the underlying causes for this remain unclear. This study aimed to explore factors affecting the incidence of EP in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).Methods:This was a retrospective study on the incidence of EP in IVF/ICSI cycles between January 1, 2013 and December 31, 2017. Patient age, infertility diagnosis (tubal factor or not), primary or secondary infertility, type of cycle (frozen-thawed or fresh), type of embryo(s) transferred (cleavage embryo or blastocyst), number of embryos transferred (one, two, or three), previous history of EP, and endometrial combined thickness were analyzed to explore their relationships with the incidence of EP. Based on clinical typing results, the patients were divided into an EP group or a non-EP group. Categorical variables were analyzed using Chi-squared test or Fisher exact test. Logistic regression analysis was performed to explore their associations with the incidence of EP.Results:The percentage of patients with primary infertility in EP group was significantly lower than that in non-EP group (31.3% vs. 46.7%, χ2 = 26.032, P < 0.001). The percentage of patients with tubal infertility in EP group was also significantly higher than that in non-EP group (89.2% vs. 63.6%, χ2 = 77.410, P < 0.001). The percentages of patients with transfer of cleavage-stage embryo or blastocyst (91.4% vs. 84.4%, χ2 = 10.132, P = 0.001) and different endometrial combined thickness (ECT) (χ2 = 18.373, P < 0.001) differed significantly between EP and non-EP groups. For patients who had a previous history of one to four EPs, the percentage of patients undergoing transfer of a cleavage-stage embryo was significantly higher in EP group than that in non-EP group (92.2% vs. 77.6%, χ2 = 13.737, P < 0.001). In multivariate logistic regression analysis, tubal infertility was strongly associated with EP (adjusted odds ratio: 3.995, 95% confidence interval: 2.706-5.897, P < 0.001).Conclusions:In IVF/ICSI cycles, transfer of a blastocyst-stage embryo, especially for patients with a previous history of EP, reduced the rate of EP. Tubal infertility was strongly associated with EP.