简介:基因同样源自赛道基因向经典致敬保时捷718BoxsterS与上一代最明显的差异,自然是在车尾首次挂上了“718”的头衔.相比保时捷911,可能大家对“718”有点陌生,这是一款以保时捷经典车型550Spyder为基础衍生出的赛车专用车型,采用了中置双座敞篷设定,且发动机盖下搭载了一台1.5升四缸发动机.所以全新718BoxsterS也传承了718经典的中置敞篷搭配四缸动力的设计.718在1957~1962年间活跃于各大赛场,并且多次夺得优异的成绩.其中,亮相第二年便拿下了勒芒24小时耐力赛的冠军与季军.1959年,718还斩获了TargaFlorio赛事的总冠军,此后的911Targa车型之名便来源于此.最后甚至被改装为单座配置,并代表保时捷出战二级方程式大赛.因此对于保时捷来说“718”并不仅仅是一串数字或一部车款,“718”所代表的是保时捷勇往直前的运动精神.
简介:InthispaperitturnsoutthataBanachlatticeXisorderisomorphictol~1(Γ)forsomenonemptysetΓiffitisaSchurspaceandalltheinfinitelydimensional,separableandclosedidealsofXareorderisomorphic.
简介:SomeKKMtheoremsandcoincidencetheoremsinvolvingadmissibleset-valuedmappingsandtheset-valuedmappingswithcompactlylocalintersectionpropertyareprovedinL-convexspaces.Asapplications,somenewfixedpointtheoremsareobtainedinL-convexspaces.Thesetheoremsimproveandgeneralizemanyimportantknownresultsinrecentliterature.
简介:ObjectiveToinvestigatethealterationsofL-typecalciumcurrent(IcaL)inabdominalaorticligation-inducedhypertrophiedratheartsandtheeffectoflosartanonthesealterations.METHODSCardiachypertrophywasinducedbyabdominalaorticligationinrats.TorecordIcaL,whole-cellpatch-clamptechniquewasused.RESULTSMembranecapacitancewaslargerinhypertrophiedcells(148±29pF)thaninsham-operatedcells(102±14pF,P<0.01)andlosartan-treatedcells(118±27,P<0.01).ThemaximalpeakIcaLWasincreasedfrom-835±124pAinsham-operatedcellsto-1404+_417pAinhypertrophiedcells(P<0.01),thecorrespondingIcaLdensitywasincreasedfrom-7.5±1.8pA.pF^1to-10.5±2.2pA.pF^1(P<0.01),whiletheywerereducedto-956-2:170pF(P<0.01)and-8.2±1.6pA.pF^1(P<0.05)respectivelyinlosartan-treatedcells.Themembranepotentialofhalfmaximalactivationofthehypertrophiedcells(-20.6±1.0mV)shiftedtomorenegativepotentialsthansham-operatedcells(-15.6±1.6mV,P<0.01)andlorsartan-treatedcells(-17.4±1.0mV,P<0.01).Theslopeoftheactivationcurveofhypertrophiedcells(5.7±0.4)wasdecreasedslightlythansham-operatedcells(6.4±0.5,P<0.05).Themembranepotentialofhalfmaximalinactivationofhypertrophiedcells(-27.6±1.9mV)shiftedtomorepositivepotentialsthansham-operatedcells(-31.4±2.2mV,P<0.05).Theslopeofinactivationcurveswerenotdifferentinthethreegroups.
简介:ProblemsaboutsurfacemountingprocessforfinepitchdevicesandreasonsonsolderbridgingofLtypeleaddevicesweldedaredepicted.Bridgingmechanismandinfluencefactorsareanalyzedwithtwo-dimensionalgeometricmodel.Basedonthis,high-densitysurfacemounttechnology(SMT)forfinepitchLtypeleaddevicesheatedbyscan-ninglaserisraised.SurfacemountprocessforQFP208onprintedcircuitboard(PCB)isstudied.Theresultsoftestsarethatitisquitepossibletosolvethesolderbridgingofsurfacemountingforpitchdeviceswithscanninglaser-heat-ingmethod.
简介:F.L.R.飞儿,由一个女生和两个男生组成的乐团,在华语乐坛惊现周杰伦后仿佛又创造新的奇迹:在推出首张专辑前,就已经红透了台湾和内地的半边天!推出同名专辑后,主打歌有三四首都在排行榜上持续大热,销量更直副周杰伦的《七里香》。
简介:BackgroundAtrialfibrillation(AF)isthemostcommonsustainedcardiacarrhythmiawithouteffectivetreatment.AFisassociatedwithatrialconductiondisturbancescausedbyelectricaland/orstructuralremodel-ing.Buttheroleofconnexin(Cx)43intheregulationofLtypecalciumchannel(LCC)remainsunclear.WehypothesizedthatCx43mightco-localizeandregulatetheLtypecalciumchannelcurrent(ICa,L).MethodsReal-timePCRandwhole-cellpatchclampwereusedtodetecttheexpressionofLCC1csubunitandthecurrentdensityofICa,L,beforeandafterCx43knockingdownrespectively.Theco-localizationofCx43withLCCwasinvestigatedbyco-immunoprecipitationandconfocalmicroscopy.ResultsKnockingdownofCx43significantlyinhibitedthecurrentdensityofICa,LthroughdecreasingthegeneexpressionofLCCα1cinculturedatrium-derivedmyocytes(HL-1cells).Cx43co-localizedwithLCCα1csubunitinatrialmyocytes.ConclusionsCx43regulatestheICa,LinatrialmyoctyesthroughLCC,representingapotentialpathogenicmechanisminatrialarrhythmias.
简介:ObjectivesTheeffectsofcarvediloloncalciumcurrent(ICa)wereinvestigatedinisolatedadultratventricularmyocytes.MethodsICawasrecordedbyusingwhole-cellpatch-clamprecordingtechnique.ResultsCarvedilolreversiblyinhibitedICainaconcentration-dependentmanner,carvedilolat0.1,0.3,1and10μmol/LintheextracellularsolutiondecreasedpeakICaby1.52%,18.04%,37.34%and72.18%,respectively.Thesteady-stateinactivationcurveofICawasshiftedtomorenegativepotentials,whiletheactivationcurvewasnotaltered.Therecoveryfrominactivationwasshiftedtorightdirection,itcouldnotberecoveredcompletely.Inaddition,Pretreatmentofventricularmyocyteswithprazosinandpropranololcouldn'tblockthecarvedilol-inducedreductionofICa.ConclusionsCarvedilolinhibitsICainadultratventricularmyocytesbymechanismsinvolvingpreferentialinteractionwiththeinactivatedstateofcalciumchannel.
简介:ObjectivesToevaluateantihypertensiveefficiencyandsafetyofanewdomesticofL-&N-typeCa^2+antagonist-eilnidipinewithimidaprilasapositivecontrol.MethodsAfter2weeks'placebowashingout,22patientsweretreatedwitheilnidipine5mgdailyand27patientsweretreatedwithimidapril5mgdaily.4weekslater,ifpatient'ssittingdiastolicbloodpressureisover90mmHg,his/herdosagewasdoubledforanother4weeks,theothersmeasuringupremainedtheirdosageunchangedforanother4weeks.Bloodpressure,heartrate,bloodandurineroutineexamination,serumglucose,serumchemicalexaminationincludingtotalcholesterol,triglyceride,HDL,LDL,transaminase,creatineetcandsidereactionswererecordedbeforeandafterthetrial.Datawereanalyzedstatistically.ResultsAfter8weeks'treatment,bloodpressurewassignificantlydecreased(P<0.05)inbothgroups,andthetwomedicineshadsimilarantihypertensiveeffects.Furthermore,thereducingofheartratewasstatisticallysignificantcomparedwithbaseline(P<0.01)inthecilnidipinegroup,butnotintheimidaprilgroup.Thenegativechronotropiceffectofcilnidipinehadlittleeffectoncontinuingthetherapy.Therewerenochangesonbloodandurineroutineexaminationandserumlipid,serumglucose,creatine,transaminaseandetcinbothgroups.Theirsidereactionsweremildandwell-tolerated.ConclusionsCilnidipinehasacon-vincingantihypertensiveeffectsimilartothatofimi-dapril.Especiallycilnidipinemaybeadministeredtopatientswithrelativelymildtachycardia.
简介:Inthispaperwestudytheexistenceoflimitcycleforcubicsystem(E)3,ofKolmogorovtypewithaconicalgebraictrajectoryF2(x,y)=ax2+2bxy+cy2+dx+ey+f=0Ithasbeenprovedinmyformerpapersthat(E)3doesn’thaveanylimitcycleonthewholeplaneIfb2-ac≠0,Nowweareinvestigatingthecasewhereb2-ac=0.Weprovethesufficientandnecessaryformula(2)or(13)witbwhich(E)3musthaveaparabolictrajectoryF2(x,y)=0.Thentherewillnotbeanylimitcycleonthefullplane.Onthebasisofthis,weconclude:ThecubicsystemofKolmogorovtypewithanon-degeneratedquadraticalgebraictrajectoryonthewholeplanehasnolimitcycle.
简介:Inthelaserwarningsystem,anon-mechanicalscanningFabry-Perot(F-P)typelaserwarningmethodanditscrucialcomponent-laserincidentsensordesignmethodarebroughtout,andtheF-Petalonwiththeinterferometricfiltercombinationisadopted.Fortheincidentlaserpulsewithacertainwavelength,thetransmittancedifferenceoftheinterferometricfiltersisindependentwithpolarizationofincidentlight,anddescendsalmostlinearlyastheincidentanglegetswider.Alaserincidentanglesensorexperimentalplatformisbuiltup,andtheexperimentiscarriedoutwithagivenlaserrangefinder.Astheresultsindicate,whentheincidentangleislessthan5o,thetransmittancedifferencemeasuredbythelaseranglesensorissignificantlylower,andthedeviationismorethan10%.Whiletheincidentangleisgreaterthan10o,thedeviationisreducedsignificantly.
简介:<正>TCLL52H78F是TCLH78系列液晶电视中的一款52英寸大屏产品,72mm的超薄机身设计,更能符合时尚家居生活理念。采用了自然光技术、动态背光技术以及附加圆偏振片,大幅提升电视画面的质量。TCLL52H78F的参数:屏幕尺寸:52英寸屏幕比例:16:9最佳分辨率:1920×1080亮度:500cd/m~2对比度:10000:1(动态)响应时间:4ms垂直可视角度:178°水平可视角度:178°机身尺寸:1308×886×269mm机身重量:40Kg产品功耗:320W输入端子:TV端子×2、AV端子×3、S端子×1、VGA输入×1、HDHI输入×2、分量输入×1其他性能DDH3数字动态全高清芯片、超高色温驱动、画面比例调节、主动数字背光调节、蓝晶彩屏技术、画厅提升技术、MEMC、全景显示、DDAS数字动态声谷、独守四驱音响