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简介：这篇论文处理象一幅个人肖像或相片那样的一个个性化的产品的最佳的定价。二个真实盒子启发的定价结构的一个新模型被介绍给文学；解决了获得容纳费用的最佳的相片；最后的产品价格。关于问题参数的敏感分析被执行。

简介：Informationfiltering(IF)systemsareimportantforpersonalizedinformationservice.However,mostcurrentIFsystemssufferfromlowqualityandlongtrainingtime.Inthispaper,arefinedevolvinginformationfilteringmethodispresented.Thismethoddescribesuser'sinformationneedfrommulti-aspectsandimprovesfilteringqualitythroughaprocesslikenaturalselection.Experimentalresultshowsthismethodcanshortentrainingtime,improvefilteringquality,andreducetherelevancebetweenfilteringresultsandtrainingsequence.

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简介：Duetodramaticallyincreasinginformationpublishedinsocialnetworks,privacyissueshavegivenrisetopublicconcerns.Althoughthepresenceofdifferentialprivacyprovidesprivacyprotectionwiththeoreticalfoundations,thetrade-offbetweenprivacyanddatautilitystilldemandsfurtherimprovement.However,mostexistingstudiesdonotconsiderthequantitativeimpactoftheadversarywhenmeasuringdatautility.Inthispaper,wefirstlyproposeapersonalizeddifferentialprivacymethodbasedonsocialdistance.Then,weanalyzethemaximumdatautilitywhenusersandadversariesareblindtothestrategysetsofeachother.Weformalizeallthepayofffunctionsinthedifferentialprivacysense,whichisfollowedbytheestablishmentofastaticBayesiangame.Thetrade-offiscalculatedbyderivingtheBayesianNashequilibriumwithamodifiedreinforcementlearningalgorithm.Theproposedmethodachievesfastconvergencebyreducingthecardinalityfromnto2.Inaddition,thein-placetrade-offcanmaximizetheuser'sdatautilityiftheactionsetsoftheuserandtheadversaryarepublicwhilethestrategysetsareunrevealed.Ourextensiveexperimentsonthereal-worlddatasetprovetheproposedmodeliseffectiveandfeasible.

简介：Cancergenomicsisarapidlygrowingdisciplineinwhichthegeneticmolecularbasisofmalignancyisstudiedatthescaleofwholegenomes.Whilethedisciplinehasbeensuccessfulwithrespecttoidentifyingspecificoncogenesandtumorsuppressorsinvolvedinoncogenesis,itisalsochallengingourapproachtomanagingpatientssufferingfromthisdeadlydisease.Specificallycancergenomicsisdrivingclinicaloncologytotakeamoremolecularapproachtodiagnosis,prognostication,andtreatmentselection.Wereviewhererecentworkundertakenincancergenomicswithanemphasisontranslationofgenomicfindings.Finally,wediscussscientificchallengesandresearchopportunitiesemergingfromfindingsderivedthroughanalysisoftumorswithhigh-depthsequencing.

简介：SocialtaggingisoneofthemostimportantcharacteristicsofWeb2.0services,andsocialtaggingsystems(STS)arebecomingmoreandmorepopularforuserstoannotate,organizeandshareitemsontheWeb.Moreover,onlinesocialnetworkhasbeenincorporatedintosocialtaggingsystems.AsmoreandmoreuserstendtointeractwithrealfriendsontheWeb,personalizeduserrecommendationserviceprovidedinsocialtaggingsystemsisveryappealing.Inthispaper,weproposeapersonalizeduserrecommendationmethod,andourmethodhandlesnotonlytheusers'interestnetworks,butalsothesocialnetworkinformation.Weempiricallyshowthatourmethodoutperformsastate-of-the-artmethodonrealdatasetfromLast.fmdatasetandDouban.

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简介：AbstractInterleukins (ILs) and associated cytokines serve as the means of communication for immune cells and non-immune cells. The use of ILs in harnessing the immune system to cancer treatment has been a promising approach. ILs not only nurture an environment enabling cancer growth but also simultaneously trigger a productive tumor-directed immune response. These properties of ILs are increasingly being explored as a strategy to improve the outcomes of cancer. Here, we describe recently innovative technological approaches that have been developed to improve the pharmacokinetics, safety, and efficacies of IL-2, 15, 10, and 18 in the treatment of melanoma. Furthermore, the combination of ILs and immune checkpoint inhibition may synergize to reshape the tumor environment, thus yielding better clinical benefits in the future.

简介：Prematureventricularcontraction(PVC)isthemostfrequentarrhythmiaencounteredinclinicalpractice.PVCmayoccurinhealthsubjects,whichisnotimminentlylife-threateningbutmayrequiretherapiestopreventfurtherproblems.So,thetimelyPVCrecognitionbecomesveryimportantfortheanalysisofelectrocardiogram(ECG),especiallyfortheremoteECGmonitoringusingmobilephones.Inthispaper,aconstructionmethodofpersonalizedECGtemplateandaPVCrecognitionmethodbasedontemplatematchingwerestudied.Firstly,weselected43ECGrecordingsfromtheMIT-BIHarrhythmiadatabase.Allrecordingsweredividedintotwodatasets(DS1fortrainingandDS2fortesting)andeachdatasetapproximatelycontainedthesameproportionofPVCbeats.Subsequently,foreachrecording(30min)inDS1,thefirst5minrecordingswereusedtoconstructthepersonalizedECGtemplateandthelast25minrecordingswereusedfortheR-wavepeaksdetectionandPVCrecognition,wherethetemplatematchingmethodwereused.ThevalidityoftheproposedmethodswastestedusingDS2.Theresultsshowedthat:1)highbeatdetectionaccuracywasachievedforbothPVCbeatsandnon-PVCbeats;2)thesensitivityandspecificityofPVCrecognitionwere99.11%and99.96%forthefirst5minrecordingsrespectively,99.17%and99.43%forthelast25minrecordingsrespectively.Alltheproposedmethodscanbereal-timeperformed,whichshowapromisingprospectfortheapplicationofECGmobilephones.

简介：应用针剌结合耳穴贴压方法治疗老年人呃逆。针剌的主穴是内关，足三里和天突。年老体虚病重者加气海和太溪，脑血管疾病者加攒竹，消化道疾病及便秘者加支沟，呼吸道疾病者加合谷。同时贴压耳穴膈，胃。耳神门，交感，皮质下和肾。结果痊愈45例，好转10例．有效率100％。

简介：AbstractTuberculosis (TB) is among the deadliest infectious diseases worldwide. Although the existing antituberculosis (anti-TB) drugs remain to be effective, the administration of these complex anti-TB drug combinations with obvious toxicity often leads to patients’ nonadherence. This may contribute toward the emergence of drug-resistant strains as well as lead to treatment failure and relapse. Therefore, in the past half century, the main focus of anti-TB drug research was to reduce the frequency of administration and toxicity and improve patients' compliance and drug sensitivity. Following these principles, the development of engineered biosafety materials is one of the most effective and promising methods in resolving these challenges. Compared with traditional drugs, biosafety materials provide a viable platform for treating TB, which are beneficial in reducing the frequency of drug administration and systemic toxicity, improving patients’ compliance and drug sensitivity, and enhancing drug targeting. In this review, we summarized the application of biosafety materials in treatment of TB in recent years and discussed the challenges faced when developing a safe, more effective, and economical pharmacotherapy against TB.

简介：Primaryesophagealadenocarcinoma(PEAC)isararemalignantdiseaseofesophagus.Becauseofitslowerincidence,theknowledgeaboutitislimitedandtherearesomeproblemsrequiringfurtherstudy.Duringrecent30years,106patientswithPEAChadbeentfeatedsurgicallyinourdepartment...

简介：Theuseoflaparoscopyhasbeenestablishedinimprovingperioperativeandpostoperativeoutcomesforpatientswithsimpleappendicitis.Laparoscopicappendectomyisassociatedwithlesswoundpain,lesswoundinfection,ashorterhospitalstay,andfasteroverallrecoverywhencomparedtotheopenappendectomyforuncomplicatedcases.Inthepasttwodecades,theuseoflaparoscopyforthetreatmentofperforatedappendicitistotaketheadvantagesofminimallyinvasivenesshasincreased.Thisarticlereviewedtheprevalence,approaches,safetydisclaimers,perioperativeandpostoperativeoutcomesofthelaparoscopicappendectomyinthetreatmentofpatientswithperforatedappendicitis.Specialissuesincludingtheconversion,intervalappendectomy,laparoscopicapproachforelderlyorobesepatientarealsodiscussedtodefinetheroleoflaparoscopictreatmentforpatientswithperforatedappendicitis.

简介：<正>OtitisMediaisacommondiseaseinthepracticeofotolaryngologyandoneofthefamous"threeinflammationsandonedeafness".Otitismediahasbeenwithhumansfromtheverybeginning.Treatmentforotitismediastartedinthewestin1774andmuchlaterinChina.

简介：Althoughmanytraditionaltherapiesareavailableforgenitalwarts(GW)，oneofthemajorproblemsinthetreatmentofGWisahighrecurrenencerate．Inordertoresolvetheproblemofrecurrence，newtheraputicapproacheshavebeeninvestigated．Newapproachesbeingexploredinclude5-fluorouracil／epinephrineinjectablecollagengel,5％imiguimodcreamandhumanpapillomavirusvaccine．Fluorouracil／epinephrineinjectablecollagengelachieveshighconcentrationoffluorouracilatthesiteofinjection．Imiguimodisanovelimmune-responesmodifier,givinggoodclearanceratesandtolerablesideeffects．AlthoughtheuseofanHPVvaccineisfaraway，preliminarystudiesshowthatitmaybepossibletodevelopsuitableprophylacticandtherapeuticvaccinestogenitalwarts．

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