简介：摘要：针对客户反馈我司GM01钢棉钢盘条在拉拔过程中偏硬、易发生断丝等问题，对其现行控冷工艺进行优化，目的降低盘条抗拉强度、改善其拉拔性能。工艺优化的主旨是降低散冷线的冷却强度，共设计两组不同控冷方案，结果表明：采用标准型冷却，盘条的抗拉强度下降，塑性提升；而在现行工艺基础上降低各风机风量及散冷辊道速度，盘条的抗拉强度虽有下降，但变化并不明显。

简介：Wehavepreviouslydemonstratedtheabilityofmalariaparasitestointerferewithspecificimmuneresponses.CD4Tcellsspecifictoparasiteantigens,butnotCD4Tcellsspecifictoanirrelevantantigen,ovalbumin(OVA),aredeletedviaapoptosisduringmalariainfection.Itisofinterest,therefore,toinvestigatetheimmuneresponsesthatdevelopedfollowingvaccinationwiththe19kDacarboxylterminusofthemerozoitesurfaceprotein1(MSP119)inmicethathadpreviouslyexperiencedmalariainfection.Inthisstudy,pre-exposureofmicetoPlasmodiumyoeliielicitednativeanti-MSP119antibodyresponses,whichcouldbeboostedbyvaccinationwithrecombinantMSP119，Likewise,infectionofMSP119-primedmicewithPlasmodiumyoelii(P.yoelii)ledtoanincreaseofanti-MSP119antibodies.MSP119vaccinationofmalariapreexposedmiceorimmunizationbyinfection/cureofMSP119-primedmiceenabledthemicetosurvivechallengeinfection,withtheformergrouphavingslightlylowerparasitaemia.Thedatasuggestthatexposuretomalariainfectionprimesanaturalimmuneresponsewhichcanbeboostedbyvaccination.Thisinformationisrelevanttothedevelopmentofavaccineforuseinindividualslivinginmalaria-endemicareas.

简介：本销售排行数据均来自于开卷图书市场研究所的“开卷全国图书零售市场观测系统”的抽样数据。这个排行，应该能够反映全国图书零售市场的真实动态，也就应该能够反映全国长篇小说零售市场的真实动态。所得数据不一定精确，但比起该书版权页上的印数和媒体鼓吹的销售数，要精确百倍。阅读这个排行，读者对长篇小说的畅销理解，就有了较为真实的参照。

简介：本销售排行数据均来自于北京开卷信息技术有限公司的“开卷全国图书零售市场观测系统”的抽样数据。这个排行，应该能够反映全国图书零售市场的真实动态，也就应该能够反映全国长篇小说零售市场的真实动态。所得数据不一定精确，但比起该书版权页上的印数和媒体鼓吹的销售数，要精确百倍。阅读这个排行，读者对长篇小说的畅销理解，就有了较为真实的参照。

简介：本销售排行数据均来自于开卷图书市场研究所的“开卷全国图书零售市场观测系统”的抽样数据。

简介：The19^thHimalaya-Karakoram-TibetWorkshop(HKT19),asanannualinternationalworkshopdevotedtopresentationsofnewresearchfindingsintheEarthsciencesandrelateddisciplinesfromtheHimalaya-Karakoram-Tibet(HKT)regionanddiscussionontheburningissues,washeldinNiseko,afamousskiresortinHokkaido,Japan.TheHKT19OrganizingCommitteehostedtheworkshoptogetherwithtwo21^stCenturyCenterofExcellencePrograms,namely,COEforthe“Neo-ScienceofNaturalHistory”(HokkaidoUniversity,ProjectLeader:H.Okada),COEfor“DynamicsoftheSun-Earth-LifeInteractiveSystem”,(NagoyaUniversity,ProjectLeader:T.Yasunari),andtheDivisionofEarthandPlanetarySciences,HokkaidoUniversity,

简介：19岁的最后一天,一早起来,我就收到富哥发过来的信息,他说:“小贵,欢迎你进入我们20岁的世界!”富哥与我同一年来到大学,因为他高考复读的缘故,比我们大一岁。我不知道他当时按下发送键的心情是否无比激动,毕竟他是我们几个死党当中率先进入20岁的人,在填表时面对“年龄”一栏,他要拿起笔,躲开众人的目光先写上一个“2”,在这一年里,他是够寂寞的。

简介：Ｒｏｔａｔｉｏｎ　ｉｎ　Ｒｅａｃｔｉｏｎ　１９Ｆ＋５１ＶＲｏｔａｔｉｏｎｉｎＲｅａｃｔｉｏｎ１９Ｆ＋５１Ｖ￥ＷａｎｇＱｉ；ＬｕＪｕｎ；ＸｕＨｕｓｈａｎ；ＬｉＳｏｎｇｌｉｎ；ＺｈｕＹｏｎｇｔａｉａｎｄＺｈａｎｇＹｕｈｕＩｎｄＬｓｓｉ...

简介：第一次出国,是在我19岁那年,不是我心存向往,而是公派留学。我去的第一个国家,是古巴。之前,在我的想象里,古巴和刚果、朝鲜、阿富汗,就是一个概念。这里应该是满街的扛着RPG的黑人,用棕榈叶子搭建的房子,街上丰田皮卡开过,卷起一阵红土。如果不是国家公派,有协议在先,我可能一辈子都不敢,也不想走这一趟。

简介：接吻所产生的其他一些有趣的效果和抗生素有关,充满激情的法国人还发明了另外很多种接吻方式,日本、法国或者其他国家的人如何接吻

简介：Ｃ１９－ＤＩＴＥＲＰＥＮＯＩＤＡＬＫＡＬＯＩＤＳＯＦＤＥＬＰＨＩＮＩＵＭＭＯＬＬＩＰＩＬＵＭ￥ＳｕｏＭｉｎｇＺＨＡＮＧ；ＱｉｎｇＹｕＯｕ(ＬａｎｚｈｏｕＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＰｈｙｓｉｃｓ，ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉ?..

简介：AbstractThe impact of coronavirus disease 2019 (COVID-19) on endometriosis (EM) is currently unclear. Here, we aimed to describe the potential influence of COVID-19 on the pathogenesis, clinical symptoms, and treatment of EM. The cytokine storm caused by COVID-19 may induce the occurrence and progression of EM, and immunosuppression of COVID-19 may help the ectopic endometrium escape from immune clearance. Consequently, the forced social isolation and the cancelation of non-emergency medical treatment during the COVID-19 pandemic aggravate anxiety and psychological pressure, which can aggravate the symptoms related to EM and delay routine medical services.

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简介：AbstractBackground:To date, there is no effective medicine to treat coronavirus disease 2019 (COVID-19), and the antiviral efficacy of arbidol in the treatment for COVID-19 remained equivocal and controversial. The purpose of this study was to evaluate the efficacy and safety of arbidol tablets in the treatment of COVID-19.Methods:This was a prospective, open-label, controlled and multicenter investigator-initiated trial involving adult patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients were stratified 1:2 to either standard-of-care (SOC) or SOC plus arbidol tablets (oral administration of 200 mg per time, three times a day for 14 days). The primary endpoint was negative conversion of SARS-CoV-2 within the first week. The rates and 95% confidential intervals were calculated for each variable.Results:A total of 99 patients with laboratory-confirmed SARS-CoV-2 infection were enrolled; 66 were assigned to the SOC plus arbidol tablets group, and 33 to the SOC group. The negative conversion rate of SARS-CoV-2 within the first week in patients receiving arbidol tablets was significantly higher than that of the SOC group (70.3% [45/64] vs. 42.4% [14/33]; difference of conversion rate 27.9%; 95% confidence interval [CI], 7.7%-48.1%; P = 0.008). Compared to those in the SOC group, patients receiving arbidol tablets had a shorter duration of clinical recovery (median 7.0 days vs. 12.0 days; hazard ratio [HR]: 1.877, 95% CI: 1.151-3.060, P = 0.006), symptom of fever (median 3.0 days vs. 12.0 days; HR: 18.990, 95% CI: 5.350-67.410, P < 0.001), as well as hospitalization (median 12.5 days vs. 20.0 days; P < 0.001). Moreover, the addition of arbidol tablets to SOC led to more rapid normalization of declined blood lymphocytes (median 10.0 days vs. 14.5 days; P > 0.05). The most common adverse event in the arbidol tablets group was the elevation of transaminase (5/200, 2.5%), and no one withdrew from the study due to adverse events or disease progression.Conclusions:SOC plus arbidol tablets significantly increase the negative conversion rate of SARS-CoV-2 within the first week and accelerate the recovery of COVID-19 patients. During the treatment with arbidol tablets, we find no significant serious adverse events.Trial registration:Chinese Clinical Trial Registry, NCT04260594, www.clinicaltrials.gov/ct2/show/NCT04260594?term= NCT04260594&draw=2&rank=1

简介：摘要由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019年冠状病毒疾病（COVID-19）已经在全球多个国家引起大流行，该病毒传染性强、致死率高，部分变异株在病毒传播性、致病性和免疫原性等多方面发生变化。无症状感染和有症状感染的COVID-19患者在免疫特征上存在异质性；不同年龄阶段的COVID-19患者的临床表现也不尽相同。目前无治疗COVID-19的特效药物，疫情控制需依赖新型冠状病毒疫苗的接种，如核酸疫苗、灭活疫苗、病毒载体疫苗、蛋白质疫苗等。本文通过对新型冠状病毒的变异、临床表现、治疗和疫苗等方面文献的复习，展现目前相关研究的进展。

简介：日前，高陵县出台《高陵县十九年无忧教育工程实施方案》，提出将在已实施十五年免费教育的基础上，全额资助今年新考入的全县所有贫困生上大学，高陵也成为全国首个全额承担大学学费的县级政府。

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简介：1．认识化学式的意义是掌握有关化学式计算的基础。化学式表示的意义；宏观上表示某种物质及该物质由哪几种_______组成。微观上表示该物质的一个分子由哪几种________构成。充分认识和真正理解化学式这两方面的意义后，才能依次进行有关化学式的计算。

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