简介:AbstractVenous thromboembolism (VTE) is a leading cause of maternal morbidity and mortality though with low rates. Compared to non-pregnant women of comparable age, women during pregnancy have five- to ten-fold increased risk of VTE, additional risk factors for VTE during pregnancy include a personal history of thrombosis, the presence of a thrombophilia, cesarean delivery, obesity, hypertension, preeclampsia, autoimmune disease, heart disease, sickle cell disease and multiple gestation. Thus, early clinical evaluation, preferably in peri-conceptional period, is crucial for VTE risk detection and, thus, for prophylaxis decision making. VTE thromboprophylaxis brought significant advantages in pregnancy outcomes and maternal deaths. Common pharmacological and mechanical forms of thromboprophylaxis includes heparin compounds, anti-embolic stockings and intermittent pneumatic compression devices. Low-molecular-weight heparin as first line strategy. Current guidelines or expert opinions on VTE treatment or prophylaxis during pregnancy diverge significantly. High quality research in this area is still needed, and China needs to develop its own VTE guidelines. Importantly, absolute risks and potential benefits of VTE thromboprophylaxis should be evaluated to make the best decisions on VTE screening, prevention, and treatment.
简介:Next-generationsequencing(NGS)technologyiscapableofsequencingmillionsorbillionsofDNAmoleculessimultaneously.Therefore,itrepresentsapromisingtoolfortheanalysisofmoleculartargetsfortheinitialdiagnosisofdisease,monitoringofdiseaseprogression,andidentifyingthemechanismofdrugresistance.OnbehalfoftheTumorBiomarkerCommitteeoftheChineseSocietyofClinicalOncology(CSCO)andtheChinaActionableGenomeConsortium(CAGC),thepresentexpertgroupherebyproposesadvisoryguidelinesonclinicalapplicationsofNGStechnologyfortheanalysisofcancerdrivergenesforprecisioncancertherapy.Thisgroupcomprisesanassemblyoflaboratorycancergeneticists,clinicaloncologists,bioinformaticians,pathologists,andotherprofessionals.Aftermultipleroundsofdiscussionsandrevisions,theexpertgrouphasreachedapreliminaryconsensusontheneedofNGSinclinicaldiagnosis,itsregulation,andcompliancestandardsinclinicalsamplecollection.Moreover,ithaspreparedNGScriteria,thesequencingstandardoperationprocedure(SOP),dataanalysis,report,andNGSplatformcertificationandvalidation.
简介:【摘要】带教老师具有双重身份,服务病人和带教学生,作为一名有责任有担当的药师,不仅做好本质工作还要为学生授业解惑,老师作为一个引导,以学生为主体,给学生一种想学的理念,激发兴趣点,引导他们的思路,说出心中的想法。对实习生和规培医师受教育程度和专业的不同,采用分层带教模式。对于工作环境和学业的繁重,应正视他们面对的实际状况,老师应多给于人文关怀,理解学生,把共同的目标展现出来,化解潜在的矛盾。耐心培养学生的责任意识、质量意识和服务意识,老师注重讲处理事情的思路和思考方向,最终让学生能够独立思考,正确的应对和处理问题,对于以后独立执业多一份保障。
简介:TheFifthGeneralAssemblyofWFASwasheldinSeoul,RepublicofKorea,onNovember12,2000.SheJing,ViceHealthMinisterandconcurrentDirector-GeneralofStateAdministrationofTraditionalChineseMedicinefromthePeople'sRepublicofChinaandHong-BinKang,ViceMayorofSeoul,RepublicofKorea,attendedtheopeningceremonyandadressedattheassembly.TheyspokehighlyofthecontributionsthatWFAShasmadetothedevelopmentandapplicationofacupuncturemedicine.Theypointedoutthatinthepast13yearssincetheestablishementofWFAS,fruitfuleffortshavebeenmadeforthedisseminationanddevelopmentofacupuncturemedicineintheworld.TheorganizationalstructureofWFASisbecomingmorematureintheprocessofpromotingthedevelopmentofacupuncturescienceandacceleratingthemutualunderstandingandcooperationamongacupuncturegroupsintheworld.ThedevelopmentofWFAShasenteredanewstagesinceWFA$wasadmittedintoofficialrelationswithWHO.
简介:当在最高的剂量管理了或在长期的用法积累了时,类固醇荷尔蒙用作immunosuppressor经常导致immunotoxicity。导致大量症状的类固醇荷尔蒙的高集中的阶段被联系到yang缺乏的状态,它是在繁体中文药涉及许多疾病的过程的yin-yang不平衡的部分。这里,我们打算由hydrocortisone(一种类固醇荷尔蒙)的肌内的注射在一个yang缺乏的动物模型在yang缺乏的条件下面调查Th1/Th2-relatedcytokine抄写的侧面。yang缺乏的症状被检测活动估计,胃口,身体重量等等。T房间增长和cytokine抄写被分析。自从典型yang缺乏的症状与减少的活动,胃口,身体重量和温度在这个模型被观察,结果证明yang缺乏的鼠标成功地被建立。更有趣地,在这个模型的IFN-,IL-2,IL-4和IL-10的抄写显著地被压制,淋巴细胞的增长显著地也减少了。结果建议yang缺乏的症状与cytokine抄写和淋巴细胞增长的缺陷的导致类固醇的减小有关。因此,通过调整cytokine生产的新奇策略可能与yang缺乏症状被看作病人的有势力途径。
简介:
简介:Chuanwu(CW),从AconitumcarmichaeliiDebx的母亲根的著名繁体中文药(TCM)……(Ranunculaceae),被用于各种各样的疾病的处理。不幸地,因为它的狭窄的治疗学的窗户,它的毒性经常被报导。在现在的学习,一个metabolomic方法被执行描绘phenotypically生物化学的不安和导致CW的毒性的潜在的机制。同时,在尿的毒性biomarkers的表示水平被分析与Gancao由联合评估detoxification(根值Glyeyrrhizae,CG),Baishao(根值PaeoniaeAlba,CS)并且Ganjiang(根茎Zingiberis,CJ),它从古典TCM药方被屏蔽。尿metabolomics被UPLC-Q-TOF-HDMS,和集体系列执行检测代谢物的信号系统地用模式识别方法被分析。作为结果,与CW毒性联系的十七biomarkers被识别,它与戊糖和glucuronate被联系互变现象,丙氨酸,aspartate,和glutamate新陈代谢,在其它之中。大多数毒性biomarkers的表示层次被相容性药有效地向正常范围调制。它显示三相容性药能有效地除去CW。在摘要,我们的工作证明metabolomics为TCM对毒性和发现detoxification方法的评估极其重要。
简介:AbstractBackground:It is crucial to improve the quality of care provided to ICU patient, therefore a national survey of the medical quality of intensive care units (ICUs) was conducted to analyze adherence to quality metrics and outcomes among critically ill patients in China from 2015 to 2019.Methods:This was an ICU-level study based on a 15-indicator online survey conducted in China. Considering that ICU care quality may vary between secondary and tertiary hospitals, direct standardization was adopted to compare the rates of ICU quality indicators among provinces/regions. Multivariate analysis was performed to identify potential factors for in-hospital mortality and factors related to ventilator-associated pneumonia (VAP), catheter-related bloodstream infections (CRBSIs), and catheter-associated urinary tract infections (CAUTIs).Results:From the survey, the proportions of structural indicators were 1.83% for the number of ICU inpatients relative to the total number of inpatients, 1.44% for ICU bed occupancy relative to the total inpatient bed occupancy, and 51.08% for inpatients with Acute Physiology and Chronic Health Evaluation II scores ≥15. The proportions of procedural indicators were 74.37% and 76.60% for 3-hour and 6-hour surviving sepsis campaign bundle compliance, respectively, 62.93% for microbiology detection, 58.24% for deep vein thrombosis prophylaxis, 1.49% for unplanned endotracheal extubations, 1.99% for extubated inpatients reintubated within 48 hours, 6.38% for unplanned transfer to the ICU, and 1.20% for 48-hour ICU readmission. The proportions of outcome indicators were 1.28‰ for VAP, 3.06‰ for CRBSI, 3.65‰ for CAUTI, and 10.19% for in-hospital mortality. Although the indicators varied greatly across provinces and regions, the treatment level of ICUs in China has been stable and improved based on various quality control indicators in the past 5 years. The overall mortality rate has dropped from 10.19% to approximately 8%.Conclusions:The quality indicators of medical care in China’s ICUs are heterogeneous, which is reflected in geographic disparities and grades of hospitals. This study is of great significance for improving the homogeneity of ICUs in China.
简介:无
简介:Throughournewly-developed'chemicalvapordepositionintegratedprocess(CVD-IP)'usingcarbondioxide(CO2)astherawmaterialandonlycarbonsourceintroduced,CO2couldbecatalyticallyactivatedandconvertedtoanewsolid-formproduct,i.e.,carbonnanotubes(CO2-derived)ataquitehighyield(thesingle-passcarbonyieldinthesolid-formcarbon-productproducedfromCO2catalyticcaptureandconversionwasmorethan30%atasingle-passcarbon-base).Forcomparison,whenonlypurecarbondioxidewasintroducedusingtheconventionalCVDmethodwithoutintegratedprocess,nosolid-formcarbon-materialproductcouldbeformed.IntheadditionofsaturatedsteamatroomtemperatureinthefeedforCVD,thereweremuchmoreend-openingcarbonnano-tubesproduced,ataslightlyhighercarbonyield.Theseinspiringworksopenedaremarkableandalternativenewapproachforcarbondioxidecatalyticcapturetosolid-formproduct,comparingwiththatofCO2sequestration(CCS)orCO2mineralization(solidification),etc.Asaresult,therewasmuchlessbodyvolumeandalmostnogreenhouseeffectforthissolid-formcarbon-materialthanthoseofprimitivecarbondioxide.
简介: