简介:Severeacutepancreatitis(SAP)cancausesystematicinflammatoryresponsesyndrome(SIRS),whichleadstoinjuryorfailureoftheinternalorgansandsystems.1Amongthem,acuterespiratorydistresssyndrome(ARDS)isasevereorfatalcomplication.Inthisarticle,theearlypreventivetreatmentforSAPcombinedwithlunginjureisstudied.
简介:Objective:Tostudytheprotectiveeffectofischemicpreconditioning(Ⅰ-pre)andischemicpostconditioning(Ⅰ-post)againstischemia/reperfusion(I/R)injuryinrat'sliver.Methods:UsingratmodelofhepaticsegmentalI/Rinjury,ratsweredividedinto5groups:GroupA(shamgroup),GroupB(I/Rinjury),GroupC(Ⅰ-pregroup),GroupD(Ⅰ-postgroup)andGroupE(combinedtreatmentofⅠ-preandⅠ-post).Serumalanineaminotransferase(ALT),aspartateaminotransferase(AST),malondiaidehyde(MDA),glutathione(GSH),superoxidedismutase(SOD),glutathioneperoxidase(GSH-Px)andmyeloperoxidase(MPO)inhepatictissuesweredetermined,respectively.Inaddition,7days'survivalofGroupsB,C,DandEwereevaluated.Results:ComparedwithGroupB,GroupsC,DandEexhibitedsignificantlydecreasedALTandASTrelease,minimizedtissueinjury,suppressedvaluesofMDAandMPO,increasedactivitiesofSOD,GSH-PxandGSH(P<0.05),aswellasimprovedanimalsurvival.ThedifferencesamongGroupsC,DandEwerenotstatisticallysignificant.Conclusions:Ⅰ-pre,Ⅰ-postandcombinedtherapyofⅠ-preandⅠ-posthaveprotectiveeffectagainsthepaticI/Rinjury,whichiscorrelatedwithitsfunctionofreducingtheproductionofreactiveoxygenspecies,maintainingtheactivitiesofantioxidantsystemsandsuppressingneutrophilsrecruitment.NoadditiveeffectcanbeobtainedinGroupE.
简介:[摘要]目的:分析下颈椎骨折脱位合并脊髓损伤早期急救治疗对预后的影响。方法:选取我中心2019年3月~2021年5月收治的下颈椎骨折脱位合并脊髓损伤患者182例实施回顾性分析研究,分析患者的一般资料,根据四肢瘫痪不同程度,通过Frankel分级课氛围四个不同的等级:A级89例,B级30例,C级21例,D级42例。受伤类型包括高空坠落患者38例,车祸受伤患者144例。评估患者的脊髓损伤水平:C2患者5例,C3患者12例,C4患者30例,C5患者88例,C6患者35例,C7患者12例。结果:为患者采取日本顾客学会的评估标准,手术前的JOA评分为(4.21±1.81)分,患者手术治疗一周后的评分为(7.95±2.23)分,最后一次随访调查评分为(10.25±2.13)分,患者术后一周后和最后一次随访调查评分较手术前评分对比具有极大差异表示统计学有意义。患者实施8小时内开展甲强龙冲击治疗的患者有68例,开展早期气管切开治疗的患者有40例。实施前路手术治疗的患者有111例,实施后路手术治疗的患者有40例,实施前后路联合手术治疗的患者有31例,患者治疗后出现4例死亡,发生肺感染的患者有5例,低蛋白血症患者有22例,发生深静脉血栓患者有3例。结论:为下颈椎骨折脱位合并脊髓损伤喊着开展早期急救治疗,能够有效促进患者机体康复,降低并发症的发生,不仅保证了治疗效果也保证了治疗安全性,提高患者治疗后的生活质量评分。