简介:Inthispaper,thep-versionofthefiniteelementmethodoflines(FEMOL)fortheanalysisoftheMindlin-Reissnerplatebendingproblemsispresentedandaclassofp-FEMOLelementswithpolynomialdegreesashighasnineisdeveloped.Numericalexamplesgiveninthispapershowtremendousperformanceofthepresentmethod;namely,rapidconvergencerate,highaccuracyforbothdisplacementsandstressresultants,removalofshear-lockingtrouble,capabilityofdealingwithdifficultproblemssuchastheboundarylayerbehaviornearafreeedgeandstressconcentrationaroundahole.
简介:THEREACTIONOFp-NITROPHENYLSULFONYLACETONITRILEWITHα,β-UNSATURATEDESTERSANDNITRILES¥GuoRenYUEandZhengZhang(DepartmentofChemist...
简介:Inthispaper,wesolvethequadraticp-functionalinequalities‖f(x+y)+f(x-y)-2f(x)-2f(y)‖≤‖ρ(2f((x+y)/2)+2f((x-y)/2)-f(x)-f(y))‖,(0.1)whereρisafixedcomplexnumberwith|ρ|<1,and‖2f((x+y)/2)+2f((x-y)/2)-f(x)-f(y)‖≤‖ρ(f(x+y)+f(x-y)-2f(x)-2f(y))‖,(0.2)whereρisafixedcomplexnumberwith|ρ|<1/2.Usingthedirectmethod,weprovetheHyers-Ulamstabilityofthequadraticρ-functionalinequalities(0.1)and(0.2)incomplexBanachspacesandprovetheHyers-Ulamstabilityofquadraticρ-functionalequationsassociatedwiththequadraticρ-functionalinequalities(0.1)and(0.2)incomplexBanachspaces.
简介:摘要目的探讨1例特殊面容合并多发畸形患儿的遗传学病因并分析其与临床表型的相关性。方法选取2020年11月4日因"孕妇胎膜早破、双胎妊娠(双绒毛膜双羊膜囊)、妊娠期糖尿病"于孕34+6周自然分娩出生的1例患儿作为研究对象,应用常规G显带方法分析患儿的染色体核型,再用高通量测序法分析患儿拷贝数变异(CNVs)的情况。结果患儿为男性,顺产出生,表现为特殊面容、尿道下裂、隐睾、四肢肌张力低等。患儿染色体核型为46,XY,del(3)(p26),高通量测序结果提示染色体3p26.3-p25.3 (60 000-9 860 000)存在约9.80 Mb的缺失,共涉及33个蛋白编码基因。结论3p26.3p25.3缺失可能是患儿的致病原因,需对其进行持续随访,提高生存质量。
简介:摘要目的通过采集肿瘤患者放疗前后外周血,探讨照射对人外周血血清miR-150-5p、miR-23a-3p表达的影响,以期为寻找辐射生物标志物提供科学依据。方法以2021年10月至2022年3月63例行放疗的肿瘤患者为研究对象,采用实时荧光定量PCR(qPCR)方法,检测患者放疗前后外周血血清miR-150-5p与miR-23a-3p的相对表达水平。比较两种miRNAs放疗前后在患者外周血血清中的差异表达变化,分析其与肿瘤类型等因素的关系。结果放疗后,患者外周血血清miR-150-5p与miR-23a-3p的相对表达量明显低于放疗前(t=4.97,Z=-2.77,P<0.05)。不同的肿瘤类型中,乳腺癌、食管癌和其他消化道肿瘤患者放疗后miR-150-5p的相对表达量降低(t=3.47、2.47、2.87,P<0.05),消化道肿瘤患者放疗后miR-23a-3p相对表达量下降(Z=-1.99,P<0.05)。在放疗前、后miR-150-5p的表达改变均不受性别、年龄、化疗和肿瘤类型等因素影响(P>0.05),而miR-23a-3p的表达改变在放疗后受性别、年龄和化疗等因素影响(t=2.04、-3.34、-2.29,P<0.05)。结论放疗可影响肿瘤患者血清中miR-150-5p的表达,其有作为辐射生物学标志物的潜力。
简介:Inthisstudy,weinvestigatetheinfluenceofdopingonthechargetransferanddevicecharacteristicsparametersinthebulkheterojunctionsolarcellsbasedonpoly(3-hexylthiophene)(P3HT)andamethanofuUerenederivative(PCBM).Organicsemiconductorsarealsoknowntobenotpureandtheyhavedefectsandimpurities,someofthemarebeingchargedandactasp-typeorn-typedopants.Calculationsofthesolarcellcharacteristicsparametersversusthep-dopinglevelhavebeendoneatthreedifferentn-dopings(N_d)thatconsistof5×10~(17)cm~(-3),10~(18)cm~(-3),and5×10~(18)cm~(-3).Weperformtheanalysisofthedopingconcentrationthroughthedrift-diffusionmodel,andcalculatethecurrentandvoltagedopingdependency.Wefindthatatthreedifferentn-dopantlevels,optimump-typedopingisaboutN_p=6×10~(18)cm~(-3).Simulationresultshaveshownthatbyincreasingdopinglevel,V_(oc)monotonicallyincreasesbydoping.CellefficiencyreachesitsmaximumatsomewhathigherdopingasFFhasitspeakatN_p=3×10~(18)cm~(-3).Moreover,thispaperdemonstratesthattheoptimumvalueforthep-dopingisaboutN_p=6×10~(18)cm~(-3)andoptimumvalueforn-dopantisN_d=10~(18)cm~(-3),respectively.Thesimulatedresultsconfirmthatdopingconsiderablyaffectstheperformanceoforganicsolarcells.