简介：摘要肺鳞癌目前治疗方式仍局限于传统的手术及放化疗，探究新的治疗方向极为重要，分子靶向基因的研究可能为肺鳞癌治疗带来突破。ROS1阳性肺癌绝大多数为肺腺癌，肺鳞癌阳性者罕见，基于报道我院收治的1例ROS1阳性肺鳞癌患者，同时检索目前国内外相关报道，对肺鳞癌患者进行ROS1检测的必要性及靶向药物克唑替尼治疗ROS1阳性的肺鳞癌的可能进行分析，为肺鳞癌的靶向治疗探索提供一种新的思路。

简介：<正>【新闻事件】10月6日卫生部通报,我国内地累计报告13例甲型H1N1流感重症病例,其中已治愈8例,死亡1例。我国内地共报告甲型H1N1流

简介：本次流感的病原体是一种新的甲型H1N1流感病毒，是猪流感、禽流感和人流感三种流感病毒基因重组后产生的新毒株。世界卫生组织（WHO）在初期将此次流感称为“猪流感”，但本次流感流行表现为在人与人之间传播，而没有发现在猪之间传播。

简介：Tostudytheelectromagnetic(EM)backscattercharacteristicsoffreakwavesatmoderateincidenceangles,weestablishanEMbackscatteringmodelforfreakwavesin(1+1)-dimensionaldeepwater.ThenonlinearinteractionbetweenfreakwavesandBraggshortwavesisconsideredtobethebasichydrodynamicspectramodulationmechanisminthemodel.NumericalresultssuggestthattheEMbackscatteringintensitiesoffreakwavesarelessthanthosefromthebackgroundseasurfaceatmoderateincidenceangles.Thenormalisedradarcrosssections(NRCSs)fromfreakwavesarehighlypolarisationdependent,evenatlowincidenceangles,whichisdifferentfromthesituationfornormalseawaves;moreover,theNRCSoffreakwavesismorepolarisationdependentthanthebackgroundseasurface.NRCSdiscrepanciesbetweenfreakwavesandthebackgroundseasurfacewithusinghorizontaltransmittinghorizomtal(HH)polarisationarelargerthanthoseusingverticaltransmittingvertical(VV)polarisation,atmoderateincidentangles.NRCSdiscrepanciesbetweenfreakwavesandbackgroundseasurfacedecreaseswiththeincreaseofincidenceangle,inbothHHandVVpolarisationradars.Asanapplication,inthesynthetic-apertureradar(SAR)imagingoffreakwaves,wesuggestthatfreakwavesshouldhaveextremelylowbackscatterNRCSsforthefreakwavefacetwiththestrongestslope.Comparedwiththebackgroundseasurface,thefreakwavesshouldbedarkerinHHpolarisationechoimagesthaninVVechoimages,inSARimages.FreakwavescanbemoreeasilydetectedfromthebackgroundseasurfaceinHHpolarisationimagesthaninVVpolarisationimages.Thepossibilityofdetectionoffreakwavesatlowincidenceanglesismuchhigherthanathighincidenceangles.

简介：随着科技的发展,已经有越来越多的相机拥有了1/8000秒的快门速度,在大多数人的认知中,使用1/8000秒快门一定比用1/250秒快门更能清晰地记录高速运动物体的瞬间状态,其实两者拍出来效果差不多!人云运动速度超过1/250秒小于1/8000秒的物体,使用1/8000秒快门拍摄,肯定可以清晰记录下来,因为快门打开速度比运动速度快!

简介：2012YamahaYZF-R1与第六代（2009款）相比主要变化在于全新的OECU系统以及扭矩控制系统．改进原则是在保证轮胎附着力的同时满足最大的输出功率，而不是盲目的追求功率。

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简介：摘要：在汽轮机停机备用时，汽轮机缸温低于150℃时判断为冷态。汽轮机判断为冷态后，盘车才允许停运。若温态和热态停运盘车，将要进行汽轮机闷缸处理，同时可能造成汽轮机轴的永久性弯曲。所以汽轮机盘车的正常投入相当重要，而汽轮机盘车投入的前提是顶轴油系统运行正常。汽机顶轴油系统中，顶轴油泵的正常出力尤为关键。本文主要通过顶轴油泵运行中出力突然下降的过程进行分析，判断出顶轴油泵出力偏低的原因。

简介：摘要：本文分析了火力发电厂相同机组负荷下，机组背压对机组供电煤耗的影响。通过详细记录机组负荷610MW工况时，不同背压下的供电煤耗平均值，分析得出相同工况下，机组背压和机组供电煤耗成正比关系。本文旨在发现机组背压对供电煤耗的影响，从而指导机组更加经济稳定运行。

简介：摘要：本文分析了火力发电厂相同机组负荷下，机组背压对机组供电煤耗的影响。通过详细记录机组负荷610MW工况时，不同背压下的供电煤耗平均值，分析得出相同工况下，机组背压和机组供电煤耗成正比关系。本文旨在发现机组背压对供电煤耗的影响，从而指导机组更加经济稳定运行。

简介：摘要：本文分析了火力发电厂相同机组负荷下，机组背压对机组供电煤耗的影响。通过详细记录机组负荷610MW工况时，不同背压下的供电煤耗平均值，分析得出相同工况下，机组背压和机组供电煤耗成正比关系。本文旨在发现机组背压对供电煤耗的影响，从而指导机组更加经济稳定运行。

简介：AbstractBackground:Emerging evidence indicates that the sineoculis homeobox homolog 1-eyes absent homolog 1 (SIX1-EYA1) transcriptional complex significantly contributes to the pathogenesis of multiple cancers by mediating the expression of genes involved in different biological processes, such as cell-cycle progression and metastasis. However, the roles of the SIX1-EYA1 transcriptional complex and its targets in colorectal cancer (CRC) are still being investigated. This study aimed to investigate the roles of SIX1-EYA1 in the pathogenesis of CRC, to screen inhibitors disrupting the SIX1-EYA1 interaction and to evaluate the efficiency of small molecules in the inhibition of CRC cell growth.Methods:Real-time quantitative polymerase chain reaction and western blotting were performed to examine gene and protein levels in CRC cells and clinical tissues (collected from CRC patients who underwent surgery in the Department of Integrated Traditional and Western Medicine, West China Hospital of Sichuan University, between 2016 and 2018, n = 24). In vivo immunoprecipitation and in vitro pulldown assays were carried out to determine SIX1-EYA1 interaction. Cell proliferation, cell survival, and cell invasion were determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, clonogenic assay, and Boyden chamber assay, respectively. The Amplified Luminescent Proximity Homogeneous Assay Screen (AlphaScreen) method was used to obtain small molecules that specifically disrupted SIX1-EYA1 interaction. CRC cells harboring different levels of SIX1/EYA1 were injected into nude mice to establish tumor xenografts, and small molecules were also injected into mice to evaluate their efficiency to inhibit tumor growth.Results:Both SIX1 and EYA1 were overexpressed in CRC cancerous tissues (for SIX1, 7.47 ± 3.54 vs.1.88 ± 0.35, t = 4.92, P = 0.008; for EYA1, 7.61 ± 2.03 vs. 2.22 ± 0.45, t = 6.73, P = 0.005). The SIX1/EYA1 complex could mediate the expression of two important genes including cyclin A1 (CCNA1) and transforming growth factor beta 1 (TGFB1) by binding to the myocyte enhancer factor 3 consensus. Knockdown of both SIX1 and EYA1 could decrease cell proliferation, cell invasion, tumor growth, and in vivo tumor growth (all P < 0.01). Two small molecules, NSC0191 and NSC0933, were obtained using AlphaScreen and they could significantly inhibit the SIX1-EYA1 interaction with a half-maximal inhibitory concentration (IC50) of 12.60 ± 1.15 μmol/L and 83.43 ± 7.24 μmol/L, respectively. Administration of these two compounds could significantly repress the expression of CCNA1 and TGFB1 and inhibit the growth of CRC cells in vitro and in vivo.Conclusions:Overexpression of the SIX1/EYA1 complex transactivated the expression of CCNA1 and TGFB1, causing the pathogenesis of CRC. Pharmacological inhibition of the SIX1-EYA1 interaction with NSC0191 and NSC0933 significantly inhibited CRC cell growth by affecting cell-cycle progression and metastasis.

简介：研究了二部图与一些图的笛卡尔乘积图的平衡指标集，得到K1，m□K1，m，K2，m□K2，m，Kn，n＋1□Pn＋1，Km，n□Ct的平衡指标集的准确值。

简介：摘要帕金森病(PD)是世界上第二常见的神经退行性疾病，它的发病机制与线粒体功能障碍、氧化应激反应以及钙稳态失衡有关。近年来，PD与Ca2+的关系成为研究热点，钙稳态失衡可通过不同的途径导致PD。细胞内Ca2+水平取决于钙库操纵性钙内流(SOCE)，而SOCE由钙释放激活钙通道调节分子1(Orai1)、基质相互作用分子1(STIM1)及瞬时受体电位通道1(TRPC1)相互作用组成的功能复合体调节。常见的PD神经毒素可通过降低Orai1-STIM1-TRPC1复合体功能，损伤SOCE及其下游的信号通路选择性损伤多巴胺能神经元，并且Orai1-STIM1-TRPC1复合体可能通过作用于小胶质细胞以及内质网调控神经炎症、自噬现象以影响PD的发生发展。因此恢复Orai1-STIM1-TRPC1复合体表达及功能，维持钙稳态可能成为PD的有效治疗靶点。

简介：笔者有幸听到了全国著名特级教师——北京市崇文区光明小学的武琼老师执教的《黄河象》一课，让我真切地感受到了在新的教学理念指导下教师应该怎样去教书，现代教师教出的学生应该是什么样的学生。现把我一些真实的感受写出来，与老师们研讨。

简介：Wehavesuccessfullysynthesized1-(2′-Phenyl)cycloproply1-2,3-epoxypropan-1-ol3,whichwillbeappliedtothekineticsstudyofoxiranylcarbinylradical.

简介：徐州市国有资产投资经营集团有限公司由原徐州市国有资产投资经营总公司、徐州市投资总公司和徐州市城市建设投资总公司三家市属投资公司，以国投总公司为主体，采取吸收合并方式组建的大型国有独资公司。2010年5月注册成立。注册资本9亿元，居我市同类投资公司之首。在短短一年零四个月的时间内，各项经济指标实现了跨越式增长，呈现出良好发展态势。从去年5月底到今年9月份．资产总额由28．3亿元增加至31．71亿元，增长12．05％；净资产由9．5亿元增加至12．92亿元，

简介：病例：患者，女，55岁，因“咳嗽、发热1周，加重伴气促3d”于2009年9月入院。患者入院前8d下午无明显诱因下出现干咳，次日开始发热，体温最高39．5℃，畏寒，咳黄脓痰。入院前4d出现痰中带血，后咳粉红色痰，至外院就诊，胸片检查提示双下肺肺炎（见图1），住院治疗，予阿奇霉素、阿莫西林．克拉维酸钾抗细菌感染及对症治疗。