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简介：近似所有人的癌症表演正常TP53基因表示的一半但是MDM2或MDMX的异常overexpression。这个事实建议有希望的癌症在指向在p53和MDM2/MDMX之间的相互作用的治疗学的策略。为了帮助，实现开发有效禁止者破坏p53-MDM2/MDMX相互作用的目标，我们系统地调查了结构并且有它和从用随机的分子的动力学模拟的一个原子论的观点的MDM2和MDMX的相互作用的禁止者的p53的相互作用特征。我们发现在MDM2和MDMX玩的结构的某特定的helices在他们的绑定给角色调音到禁止者，并且氢契约在MDM2或MDMX与它的对应物由p53的Trp23残余形成了，这在vivo从MDM2-p53建筑群决定MDM2-p53相互作用的混乱和p53的代替的动态比赛过程。结果在这报导纸被期望为设计功能的禁止者并且认识到癌症基因治疗的新策略提供基本信息。

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简介：TheGroupofNuclearStructureResearchatIMPhasdevotedmuchefforttothestudyofin-beam-rayspectroscopyandγ-decayspectroscopy.Oneterminalforin-beam-rayspectroscopyhasbeennewlybuiltupin2016.Asforγ-decayspectroscopy,twopointsneedtobeemphasized.Inordertostudythein-beam-rayspectroscopy,aballwasplacedattheterminalofnewTL2beamline.Threequadrupolemagnetsfollowingthedipolemagnetarethemainbuildingblocksalongthebeamline.Theballconsistsof8cloverand16HPGedetectorswithaCsIballinsidetoselectthechargedparticlechannel.Awallisolatingtheballfromthequadrupoleswasusedtoshieldtheradiationproducedbytheacceleratoranddepositingenergyinthedetectors,whichmayresultinahighbackground.Theinstallationwasfinishedin2016andtheexperimentforin-beam-rayspectroscopyisexpectedtoperformin2017.

简介：TheGroupofNuclearStructureResearchatIMPhasdevotedmuchefforttothelifetimemeasurementsoflowlyingexcitedstatesvia??fasttimingcoincidence.Twoexperimentswereperformedin2015attheradioactivebeamlineRIBLL[1]andgas-filledrecoilseparatorSHANS[2].

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简介：QuantumdynamicscalculationsforthetitlereactionH(2S)+S2(X3-Σg)→SH(X2Π)+S(3P)areperformedbyusingagloballyaccuratedoublemany-bodyexpansionpotentialenergysurface[J.Phys.Chem.A1155274(2011)].TheChebyshevrealwavepacketpropagationmethodisemployedtoobtainthedynamicalinformation,suchasreactionprobability,initialstate-specifiedintegralcrosssection,andthermalrateconstant.Itisfoundnotonlythatthereisareactionthresholdnear0.7eVinbothreactionprobabilitiesandintegralcrosssectioncurves,butalsothatboththeprobabilityandcrosssectionincreasefirstlyandthendecreaseasthecollisionenergyincreases.Theexistenceoftheresonancestructureinboththeprobabilityandcrosssectioncurvesisascribedtothedeeppotentialwell.Thecalculationoftherateconstantrevealsthatthereactionoccurringonthepotentialenergysurfaceoftheground-stateHS2isslowtotakeplace.

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简介：Theoreticalmodelsofstellarevolutionpredictnegligiblequantitiesof6Li,9Be,and11Binthehydrogenburningphasesofastar’sevolution[1].TheprimordialBig-Bangnucleosynthesis(BBN)modelmightbemoregenerousinitsproductionoftheseelements[2].Theradiative-capturecrosssectionforprotoncaptureon11Bleadingto12CissmallatastrophysicallyinterestingenergiesbecauseofthelargeCoulombbarrier.

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简介：Themassesofneutron-defcientnuclidesplayacriticalroleinthecalculationofastrophysicalrapidproton-captureprocesses[1].Neutron-defcientnuclideswithmassnumber∧around80arethelastsetofnuclideswithunknownmassesonthepathwayofvp-process[2].Themassmeasurementofnuclideswouldbeveryuseful.In2016,massesofneutron-defcientnuclides79Y,81Zr,82Zr,83Nband84Nbnucleiwerepreciselymeasureddirectlybytheexperimentalstorage-ringCSReatLanzhou.

简介：Weinvestigateanewclassofperiodicsolutionsto(2+1)-dimensionalKdVequations,byboththelinearsuperpositionapproachandthemappingdeformationmethod.Thesenewperiodicsolutionsaresuitablecombinationsoftheperiodicsolutionstothe(2+1)-dimensionalKdVequationsobtainedbymeansoftheJacobianellipticfunctionmethod,buttheypossessdifferentperiodsandvelocities.

简介：Asimplemethodisappliedtocalculatingtheisotopeshifts(ISs)on5S1/2→4D3/2,5/2transitionsof87,88Sr+.FirstwehavecalculatedtheISsoflowertransitionsonaseriesofalkali-likesystemssuchasB2+,Ca+andBa+,whichareinagreementwithotherworks.ThentheISson5S1/2→4D3/2,5/2transitionsof87,88Sr+,whichareusefultostudytheSr+opticalfrequencystandard,areevaluated.

简介：TheeffectsofSO2,SO3ondenovosynthesisofpolychlorinateddibenzo-p-dioxins(PCDDs)anddibenzofurans(PCDFs)werestudiedusingmodelflyashesincorporatingcopperoxideandactivatedcarbon.ItwasfoundthattheinhibitiveeffectofSO2onPCDD/FsformationissimilartothatofSO3.Toinvestigatetheinhibitionmechanism,CuSO4formationsfrombothCuOandCuCl2wereexamined.TheabilityofSO3toconvertCuCl2andCuOonasilicasupportintosulfateismuchstrongerthanthatofSO2.However,replacingsilicabyactivatedcarbonleadstoamuchhighconversionofCuCl2toCuSO4inthepresenceofSO2.ThepromotionbyactivatedcarbonisexplainedbythereductionofCuCl2toCu2Cl2andtheeventualconversionofCu2Cl2intoCuSO4isthemaininhibitionmechanismofSO2ondenovosynthesisofPCDD/Fs.

简介：Nucleon-nucleon(NN)correlationsandtheirisospindependenceinasymmetricnuclearmatterareofgreatnterestsincetheyarecloselyrelatedtothestructureofneutron-richnuclei[1],particleproductioninheavy-ionollisions[2],andneutron-starphysics[3].Themany-bodycorrelationsamongnucleonscanbedirectlyreflectedintheneutronandprotonspectralfunctions[4],andthelattermayplayanimportantroleinunderstandingthenatureftheNNcorrelations,especiallytheshort-rangeandtensorcorrelationsinasymmetricnuclearmatter.

简介：Weprovideanewclassofinteriorsolutionofa(2+1)-dimensionalanisotropicstarinFinchandSkeaspacetimecorrespondingtotheBTZblackhole.WedevelopthemodelbyconsideringtheMITbagmodelEOSandaparticularansatzforthemetricfunctiongrrproposedbyFinchandSkea[M.R.FinchandJ.E.F.Skea,Class.Quantum.Grav.6(1989)467].Ourmodelisfreefromcentralsingularityandsatisfiesallthephysicalrequirementsfortheacceptabilityofthemodel.

简介：Startingfromthevariableseparationsolutionobtainedbyusingtheextendedhomogenousbalancemethod,anewclassofcombinedstructures,suchasmulti-peakonandmulti-dromionsolution,multi-compactonandmultidromionsolution,multi-peakonandmulti-compactonsolution,forthe(2+1)-dimensionalNizhnik-Novikov-Veselovequationarefoundbyselectingappropriatefunctions.Thesenewstructuresexhibitnovelinteractionfeatures.Theirinteractionbehaviorisverysimilartothecompletelynonelasticcollisionsbetweentwoclassicalparticles.

简介：1-(2-chlorophenyl)ethanol(CPE)isofhealthandenvironmentalconcernduetoitstoxicityanditsuseasaninter-mediateinpharmaceuticalmanufacturing.ThecurrentworkdealswiththecatalyticreductivedechlorinationanddetoxificationofCPEbyPd/Febimetal.CPEwaseffectivelydechlorinatedto1-phenylethanol(PE)accompaniedbytheequivalentreleaseofchloride.TheextentofCPEdechlorinationincreasedwithtemperature,FedosageandPdloading.AdecreaseinsolutionpHincreasedCPEdechlorination,resultingpresumablyfromanincreaseinhydrogenproduction.Underthespecificconditionsof20g/LPd/Fe,0.10%Pd(w/w)andinitialpH5-6,theCPEdechlorinationwascompletedwithin145min.Thedechlorinationfol-lowedapseudo-first-orderkineticswithanactivationenergyof56.7kJ/mol.TheresultsoftoxicitytestingshowedthatCPEwasverytoxictoChlorella,whereasPEshowedlittletoxicity.Thetoxicityofthereactionsolutiondeclinedgraduallyandthepro-motingeffectsonChlorellaintensifiedconsequentlywiththedechlorinationprocess.Thus,thereductivedechlorinationofCPEtoPEbyPd/Fewasadetoxificationprocess.ItmaybeusedtoeffectivelyreducethetoxicologicaleffectsofCPE-contaminatedwastewater,therebyenhancingtheperformanceofsubsequentbiologicalprocessesinwastewatertreatment.

简介：AnovelSr2CuInO3Soxysulfidep-typesemiconductorphotocatalysthasbeenpreparedbysolidstatereactionmethodanditexhibitsintriguingvisiblelightabsorptionpropertieswithabandgapof2.3eV.Thep-typesemiconductorcharacterofthesynthesizedSr2CuInO3SwasconfirmedbyHallefficientmeasurementandMott-Schottkyplotanalysis.First-principlesdensityfunctionaltheorycalculations(DFT)andelectrochemicalmeasurementswereperformedtoelucidatetheelectronicstructureandtheenergybandlocations.Itwasfoundthattheas-synthesizedSr2CuInO3Sphotocatalysthasappreciateconductionandvalencebandpositionsforhydrogenandoxygenevolution,respectively.Photocatalytichydrogenproductionexperimentsunderavisiblelightirradiation(λ>420nm)werecarriedoutbyloadingdifferentmetalandmetal-likecocatalystsonSr2CuInO3SandRhwasfoundtobethebestoneamongthetestedones.

简介：Westudytheentanglementinanisotropic(1/2,1)mixed-spinHeisenbergXYmodelunderthepresenceofanexternalmagneticfieldatthermalequilibrium.Byadjustingtheanisotropicparameterandthemagneticfield,oneisabletoobtainentanglementathighertemperature.Wefindtheevidenceofthequantumphasetransitioninthemodelandobservethatthequantumphasetransitionpointatlowtemperaturemovestowardweakmagneticfieldwiththeincreaseoftheanisotropicparameter.