简介：一系列1-[2-(2-methoxyphenylthio)本甲基]-4-arylpiperazines衍生物基于5-HT1A/SSRI药设计策略被设计并且综合。综合混合物为他们的双5-HT1A/5-HTT活动被评估。

简介：新carbene钌建筑群，1,3二度(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene)(PPh3)Cl2-Ru=CHPh,被综合并且为1-hexene的换位用作催化剂。产生建筑群展出了其TOF直到6680h的很高催化的活动?1。然而，同时重要的石蜡异构化被观察并且能是由改变反应条件的surpressed，例如温度，时间，alkene/Ru臼齿的比率和溶剂。

简介：八新奇1,4-disubstitutedphthalazines(714)被设计并且综合。所有综合混合物的结构被红外，1HNMR，13CNMR，MS和元素的分析证实。他们的在里面对癌症房间线(Bel-7402和HT-1080)的vitro细胞毒性被标准MTT评估试金。在他们之中，加重9和11比cisplatin展出了更多的有势力细胞毒性。

简介：Newphosphorus-andselenium-containingheterocyclyes,1,3,2,6-dioxaphosphaselena-cyclooctanes(la-1h),weresynthesizedbythereactionofbis(2-hydroxyethyl)selenidewithRP(X)Cl2whereR=alkoxyl,aroxyl,arylandX=Oorlonepair.Theirstructuresweredeterminedbyspectro-scopiesandelementalanalysesandfinallyconfirmedbytheX-raycrystallographicanalysisof1c.Themolecularstructuresoftheheterocycleswerediscussedintermofconformationalanalysis.

简介：Sumoylationisanimportantproteinmodificationdiscoveredrecently.SUMO(smallubiquitin-relatedmodifier)pathwayregulatestheproteinstabilityandtranscriptionalactivitywitha12-kDasmallmolecularprotein,SUMO,ligatedtothetargetprotein.ThepurificationofSUMOproteinsisakeysteptorevealtheirfunction.ThepurposeofthisstudywastoconstructtherecombinantSUMO1geneclonedtoapGEX-4T-1vectortoexpressandpurifytheSUMO1-GSTfusionproteininEscherichiacoli.First,thefulllengthDNAsequenceofSUMO1genewasamplifiedbyPCRandwasligatedtopMD18-Tvector.ThentheSUMO1genewassubclonedtopGEX-4T-1prokaryoticexpressionvectorbetweenBamHIandXhoIsites,andtransformedinEscherichiacoliDH5αcells.Therightcolonieswereidentifiedbyrestrictiveenzymedigestionandsequencing.ThecorrectrebombinantplasmidofpGEX-4T-1-SUMO1wastransformedinEscherichiacoliBL21cellsandtheninducedbyIPTG(isopropyl-β-D-1-thiogalacto-pyranoside)toexpresstheSUMO1-GSTfusionprotein.ThehighlypurifiedSUMO1-GST(glutathioneS-transferase)fusionproteinwasobtainedbyaffinitychromatography.Finally,thepropertiesofSUMO1-GSTfusionproteinwereconfirmedbyCoomassiebrilliantbluestrainandWesternblotanalysis.TherecombinantplasmidofpGEX-4T-1-SUMO1wassuccessfullyconstructed,andSUMO1-GSTfusionproteinsweresuccessfullyexpressed.

简介：Thetitlecomplex,[La(baec)1/2(H2btec)1/2(H2O)]n(H4btec=1,2,4,5-benzenetetracarboxylicacid)(1)wassynthesizedbythehydrothermalreactionof1,2,4,5-benzenetetracarboxylicdianhydridewithLa(NO3)3·6H2OinH2O,andcrystallizesinthetriclinicsystem,spacegroupP-1withα=0.64403(3)nm,b=0.94500(4)nm,c=0.96380(5)nm,α=88.535(2)°,β=100.314(2)°,γ=76.6470(10)°,V=1.69968(10)nm^3,Z=2,andfinalR=0.0274,Rw=0.0735.In1,eachLa(Ⅲ）ioniscoordinatedbyeightoxygenatomsfromsixcarboxylategroupsandonecoordinatedwatermolecule.TwodifferentcoordinstionmodesofH4btecwerePresentinthestructure,oneofwhichcontainstwoprotonatedcarboxylategrougpstobalancethecharge.

简介：有CuBr2和CdI2催化的公司的1-bromo-6-chlorohexane的Photopromotedcarbonylation在周围的条件下面被执行了。结果显示carbonylation在CuBr2的催化作用下面继续chloroesterClCH2(CH2)5COOCH3的主要产品。而且，carbonylation的活动能被基本添加剂的增加改进(NaOAc，Na3PO4或(n-C4H9)3N)。在这些添加剂之中，(n-C4H9)3N以ClCH2(CH2)5COOCH3的收益是最有效的。然而，代替BrCH2(CH2)5COOCH3的氯产品的methoxycarbonyl没面对CdI2被获得。这与monochloroalkane的carbonylation相当不同。

简介：2-Amino-l,l-diferrocenylethanol2waspreparedbyreductionoftrimethylsilylcyanohydrinetherofdiferrocenylketone.Thecrystalstructureof2wasfurtherdefinedbyX-raydiffraction.

简介：一系列1,4代用品phthalazine衍生物被设计并且综合。所有准备混合物在vitro对A549，HT-29和MDA-MB-231房间线为他们的细胞毒素的活动被屏蔽。在他们之中，混合物7a鈥?h从1nmol/L与IC50价值为MDA-MB-231房间线显示出优秀选择到0.92渭mol/L。这些衍生物的初步的SAR研究被执行。

简介：Novelsulfur-containingcompounds(3a–3c,4a–4c)wereobtainedinethanolwith1,3-diphenyl-2-propanoneasthestartingmaterial.Theadvantagesofthisprocedureweremildreactionconditions,simpleprotocol,andhighyields.ThestructuresoftheproductswerecharacterizedbyIR,1HNMR,MSandelementaryanalysis.Thecrystalofthenewcompound4abelongstomonoclinic,spacegroupC2witha=18.727(3),b=6.5179(9),c=13.7576(18),b=131.0610(10)°,V=1266.2(3)A3,Z=2,Dc=2.136g/cm3,μ=1.078mm-1,F(000)=843,R=0.0490andwR=0.1247for3211observedreflectionwithI>2δ(I).X-rayanalysisrevealsthatthemoleculeisnotsymmetrical,themolecularstructureisstabilizedbyweakp–pstackinginteractions,andnoclassicalhydrogenbondscanbeobserved.

简介：新奇pyridopyrazolopyrimidinone衍生物作为潜在的PDE5禁止者被设计并且综合。目标混合物比sildenafil对人的血小板PDE5，而是更少的有势力表明了重要禁止的活动。

简介：

简介：Twoseriesofnovelcompoundsdesignedashybridsof1-arylnaphthalenelignanswithdihydroisoquinolinesorisoquinolinesweresynthesizedandevaluatedfortheircytotoxicitiesonhumantumorcelllines,suchasA549,Hela,PC-3andKB.SomeofthesyntheticcompoundsexhibitedtheirIC50valuesonselectedcelllinesatμmol/Lscale.

简介：Anovertphenotypeofaquaporin-1knockout(AQP1ko)miceisgrowthretardation,suggestingpossibledefectsinbonedevelopmentandmetabolism.Inthepresentstudy,weanalyzedthebonemineraldensity(BMD),bonecalciumandphosphoruscontents,andbonemetabolisminanAQP1komousemodel.TheBMDoffemursinAQP1komicewassignificantlylowerthanthatoflitter-matchedwildtypemiceasmeasuredbydualenergyX-rayabsorptiometry.Consistently,thecontentsofbonetotalcalciumandphosphoruswerealsosignificantlylowerinAQP1komice.ThereducedBMDcausedbyAQP1deficiencymainlyaffectmalemice.Bonemetabolicactivity,asindicatedby99mTc-MDPabsorptionmeasurements,wasremarkablyreducedinAQP1komice.TheseresultsprovidethefirstevidencethatAQP1playanimportantroleinbonestructureandmetabolism.

简介：Using2-bromo-1-methylpyridimiumiodideascarboxylactivatingagent,10ansa-macrolactamswerepreparedconvenientlyfromthecorrespondingseco-precursorw-aminoacidsintheyieldsof78-2%.

简介：1,2-rearrangementsofcarbenes:CCH2X（X=CH2,NHandO）arestudiedbyusingabinitiogradientmethod.HeteroatomsNandOstabilizethecarbeneanddecreaseitsreactivity,mainlybychangingfrontiermolecularorbitals,butretainthewayofthereaction.ThereactionstartsfromtheattackofthemigratinghydrogenonthecarbenepAOandendswiththeentranceofthehydrogenintothecarbeneσorbital.ReactivitiesareintheorderofX=CH2>NH>O.Thereactionisexothermicorendothermicaccordingtowhethertheproductisa4n+2or4nπelectronmolecule.

简介：Copper-dopedZnOnanoparticlesweresynthesizedbythesol-gelmethod.TheX-raydiffraction(XRD)resultshowsthatZn1-xCuxO(x≤0.04)samplesaresinglephasewithZnO-likewurtzitestructure,whilethesecondaryphaseCuisobservedinaZn0.95Cu0.05Osample.MagneticmeasurementsindicatethatZn1-xCuxO(x≤0.04)samplesareferromagneticatroomtemperature.Astronggreenpeak(520nm)wasobservedexceptforUVbandpeakinphotoluminescent(PL)spectrumofZn0.98Cu0.02O.

简介：Enzymaticalcoholysishasbeendevelopedforthepreparationofsomechiral1-and2-hydroxyalkanephosphonateswithhighopticalpurity.Thismethodensurestheconvenientaccesstotheopticallypurephosphocarnitine,phosphogabobandphosphomycin.

简介：一系列1-(N-(2-(2-methoxyphenylthio)本甲基)-N-methylamino-3-aryloxypropan-2-ols衍生物基于5-HT1A/SSRI药设计策略被设计并且综合。综合混合物为他们的双5-HT1A/5-HTT活动被评估。

简介：ThepossiblegeometricalstructuresandrelativestabilitiesofsemiconductormicroclustersGa.P.(n=1-4)werestudiedbyvirtueofdensityfunctionalcalculationswithgeneralizedgradientapproximation(B3LYP).ForthemoststableisomersofGa,,P.(n=1-4)clusters,theelectronicstructure,vibrationalproperties.dipolemoment,polarizabilityandionizationpotentialwereanalyzedbymeansofHF.MP2.CISDandB3LYPmethodswithdifferentbasissets.