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简介：为产后的消沉加心理干预观察针灸的治疗学的效果。

简介：[摘要] 目的：探讨个性化护理干预在慢性心衰护理中的效果。方法：从2020年1月至2021年3月，来我院治疗的102例慢性心衰患者。根据入院编号奇偶性分组：奇数编号的51例进入对照组，实施心内科护理常规；偶数编号的51例进入试验组，进行个性化护理干预。比较护理依从性和生活质量。结果：试验组依从性优良率更高（96.08%vs84.31%）；两组患者干预后的QOL均明显增高，且试验组评分结果较对照组更高，经检验有统计学差异（P＜0.05）。结论：对慢性心衰患者进行个性化护理干预，能提高护理依从性，有助于改善生活质量。

简介：Purpose':Physicalactivity(PA)andfundamentalmotorskillsareimportantcomponentsofcurrentandfuturetrajectoriesofhealthinyoungchildren.Thisstudyexaminedtheeffectsofa5-weekmotorskillinterventiononpreschoolers,motorskillcompetenceandtheirPAbehaviorswhileparticipatinginthemotorskillinterventionoroutdoorfreeplay(recess).Methods'.Atotalof102preschoolersservedasparticipantsandwerepartofamotorskillinterventiongroup(n=64)oracontrol/outdoorfreeplaygroup(n=38).Children'smotorskillswereassessedbeforeandaftertheinterventionusingtheTestofGrossMotorDevelopment-3rdedition.PAduringthemotorskillinterventionandoutdoorfreeplaywasassessedusingaccelerometersbothimmediatelybeforethestart(baseline,Week0orWeek1)andend(late.Week5orWeek6)oftheintervention.Results:Allchildrensignificantlyimprovedtheirmotorskillsfrombaselinetolateassessment(p<0.05).Childreninthemotorskillinterventiondemonstratedgreaterratesofchange(p<0.001)andscoredhigheronallmotorskillsatthelateassessmentcomparedwiththecontrolgroup(p<0.001).Therewasnoeffectofgroup(controlvs.intervention),buttherewasasignificanteffectofsexonchildren'sPAduringoutdoorfreeplayatbaseline(p<0.05).Similarly,therewasnoeffectofgrouponPAduringdayswiththemovementprogram(interventionvs.outdoorfreeplay)ateithertimepoint,butboysweremoreactivethangirlsatthelateassessment(p<0.05).Last,childrenintheinterventionengagedinmorePAwhileparticipatingintheinterventiontowardtheendoftheinterventionthanatthebeginning.Conclusion'.The5-weekmotorskillinterventionwaseffectiveatimprovingpreschoolers,motorskillsandratesofchangeinmotorskillswerehigherforchildrenwhocompletedtheinterventioncomparedwithchildreninthecontrolgroup.PreschoolersintheinterventiondiddemonstratePAchangeswhileparticipatingintheintervention,

简介：ObjectivesToevaluatethefeasibilityandsafetyofdistalprotectiondevice(PercuSurge)duringpercutaneouscoronaryintervention(PCI)inpatientswithacutecoronarysyndrome.MethodsFromOctober2004toAugust2007,40patientswithhighriskacutecoronarysyndromewhoreceivedprimarycoronaryinterventionwereincludedinthisstudy.PatientsweredividedintotwogroupsaccordingtowhetherPercuSurgewasattemptedduringPCI.Thebasicclinicalcharacteristics,angiographicresults,andfollow-updatabeforedischargewerecompared.Coronaryarteriesbloodflowthrombolysisinmyocardialinfarction(TIMI)grade,TIMImyocardialperfusion(TMP)gradeandtherateofno-reflowwereperformedinallcasesafterPCI.ResultsTherewasnosignificantdifferencebetweenthetwogroupsinbasicclinicalcharacteristicsandangiographybeforePCI(P>0.05).AllpatientsunderwentPCIsuccessfullyinbothgroups.InthePercuSurgegroup,PCIwithPercuSurgeguardwireprotectionwasperformedsuccessfullyin18patients.TherewassignificantdifferencebetweenthetwogroupsinTIMI3flowsgainedintargetvesselsafterPCI.BetterpercentageofTMPgrade3oftargetvesselswasachievedinPercuSurgegroup.Lessno-reflowwerefoundinPercuSurgegroup.TherewerelowerpeaktroponinIandserumMBisoenzymeofcreatinekinaselevels,higherleftventricularejectionfractionandsmallerleftventricularend-diastolicdimensioninthePercuSurgegroupafterPCIatthedatebeforedischarge(P<0.05).TherewasnomajoradversecardiaceventsinPercuSurgegroup,onlyonepatientdiedinthecontrolgroup.ConclusionsThisstudydemonstratesthatusingthePercuSurgeGuardwiresystemduringPCIinhighriskacutecoronarysyndromepatientstopreventno-reflowisfeasibilityandsafety.

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简介：冷战后的欧盟在指导方针上出了问题，她不知是把自己建成一个联邦（美国式的联邦或合作型的联邦）还是建成一个地处欧洲的小联合国。对这个问题我们现在必须给出答案，否则欧盟还会陷入危机。

简介：Percutaneouscoronaryintervention(PCI)improvessymptomsandprognosisinischemia-inducing,functionallysignificant,coronarylesions.Useoffractionalflowreserveallowsphysicianstoinvestigatetheischemia-inducingpotentialofaspecificlesionandcanbeusedtoguidecoronaryrevascularization,especiallyinmultivesselcoronaryarterydisease.Fractionalflowreserve-guidedPCIhasbeenextensivelyinvestigated.Resultsshowthatdeferralofstentinginnon-significantlesionsissafe,whereasdeferralofstentinginfunctionallysignificantlesionsworsensoutcome.FFR-guidedPCIimprovesoutcomeinmultivesseldiseaseoverangiography-guidedPCI.Untilrecently,therewaslittleknownaboutthelong-termoutcomeofFFR-guidedrevascularizationanditsvalidityinacutecoronarysyndromes.Thisreviewaimstoaddressthenewevidenceregardinglong-termappropriatenessofFFR-guidedPCI,theneedforhyperemiatoevaluatefunctionalseverity,andtheuseofFFRinacutecoronarysyndromes.

简介：[摘要] 目的：探讨急性心肌梗死介入治疗中心律失常的护理干预效果。方法：从2020年1月至2021年5月，在我院介入治疗的94例急性心肌梗死患者。根据入院编号奇偶性分组：奇数编号的47例进入对照组，实施常规护理；偶数编号的47例进入试验组，进行有效护理干预。比较护理满意度和治疗指标。结果：相比于对照组，试验组总满意率更高（95.74%vs82.98%），患者的心率、QT离散度更低，QTC间期更大，经检验有统计学差异（P＜0.05）。结论：急性心肌梗死介入治疗中发生心律失常的患者，实施有效护理干预能改善治疗效果，提高患者满意度。

简介：BackgroundAfterpercutaneouscoronaryintervention(PCI),somepatientsmaysufferfromrestenosisandstentthrombosis.Manystudiessuggestthatendothelialprogenitorcell(EPC)hasanimportantroleinpreventingrestenosisandstentthrombosis.AnovelstentwhichcanattractEPChasbeendesignedtoprovideabetteroutcomefortheseproblems.MethodThedataofthepresentreviewwasobtainedbysearchingPUBMEDandotherdatabases(1994-2011)usingthekeytermsof'endothelialprogenitorcell','reendothelialization','restenosis','stentthrombosis',and'percutaneouscoronaryintervention'.ResultRapidreendothelializationisessentialinpreventingrestenosisandstentthrombosis.EPCcandifferentiateintoendothelialcellandacceleratethereendothelialization.Afternumerouspreclinicalandclinicalresearches,thecorrelationbetweencirculatingEPCstorestenosisstillremainspoorlyunderstood.However,manystudieshaveshowntheimportantroleofEPCindiminishingtheriskofthrombosisfollowingstentimplantation.Somepharmacologicalagentshavebeenreportedcanincreasethenumberand/orfunctionsofEPC.Recently,CD34+antibodycoatedstenthasbeendevelopedtoattractEPCtothehealingendothelium,andhasshowedfavorableresults.ConclusionEPChasimportantroleinrapidreendothelializationaftervascularinjury.EPCcanpreventstentthrombosisafterPCI,howevertheeffectsofEPCinpreventingrestenosisneedfurtherinvestigations.ThecapturingCD34+stentissafeandsignificantlydecreasesstentthrombosis.

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简介：AbstractBackground:The development of the technique has improved the success rate of percutaneous coronary intervention (PCI) for instent chronic total occlusion (IS-CTO). However, long-term outcomes remain unclear. The present study sought to investigate long-term outcomes of PCI for IS-CTO.Methods:A total of 474 IS-CTO patients were enrolled at two cardiac centers from 2015 to 2018 retrospectively. These patients were allocated into either successful or failed IS-CTO PCI groups. The primary endpoint (major adverse cardiac events [MACE]) consisted of recurrent angina pectoris (RAP), target-vessel myocardial infarction (MI), heart failure, cardiac death, or ischemia-driven target-vessel revascularization (TVR) at follow-up. Multivariable Cox regression analysis was used to investigate the association between treatment appropriateness and clinical outcomes.Results:A total of 367 patients were successfully treated with IS-CTO PCI while 107 patients had failed recanalization. After a median follow-up of 30 months (interquartile range: 17-42 months), no significant difference was observed between the two groups for the following parameters: cardiac death (successful PCI vs. failed PCI: 0.9% vs. 2.7%; adjusted hazard ratio [HR]: 1.442; 95% confidence interval [CI]: 0.21-9.887; P = 0.709), RAP (successful PCI vs. failed PCI: 40.8% vs. 40.0%; adjusted HR: 1.025; 95% CI: 0.683-1.538; P = 0.905), heart failure (successful PCI vs. failed PCI: 6.1% vs. 2.7%; adjusted HR: 0.281; 95% CI: 0.065-1.206; P = 0.088), target-vessel related MI (successful PCI vs. failed PCI: 1.5% vs. 2.7%; adjusted HR: 1.150; 95% CI: 0.221-5.995; P = 0.868), MACE (successful PCI vs. failed PCI: 44.2% vs. 45.3%; adjusted HR: 1.052; 95% CI: 0.717-1.543; P = 0.797). More patients were free of angina in the successful IS-CTO PCI group compared with failed PCI in the first (80.4% vs. 60%, P < 0.01) and second years (73.3% vs. 60.0%, P = 0.02) following up. Successful IS-CTO PCI had a lower incidence of MACE in the first and second years (20.2% vs. 40.0%, P < 0.01; 27.9% vs. 41.3%, P = 0.023) compared with failed PCI. After a median follow-up of 30 months, the reocclusion rate was 28.5% and TVR was 26.1% in the successful IS-CTO PCI group. Receiving >18 months of dual antiplatelet therapy (DAPT) was an independent predictor of decreased risk of TVR (HR: 2.682; 95% CI: 1.295-5.578; P = 0.008) or MACE (without TVR) (HR: 1.898; 95% CI: 1.036-3.479; P = 0.038) in successful IS-CTO PCI.Conclusions:After a median follow-up of 30 months, the successful IS-CTO PCI group had MACE similar to that of the failed PCI group. However, the successful IS-CTO PCI group had improved angina symptoms and were free from requiring coronary artery bypass grafting in the first or second years. To decrease MACE, DAPT was found to be essential and recommended for at least 18 months for IS-CTO PCI.

简介：Theadipocytokine,apelin-13,isanabundantlyexpressedpeptideinthenervoussystem.Apelin-13protectsthebrainagainstischemia/reperfusioninjuryandattenuatestraumaticbraininjurybysuppressingautophagy.However,secondaryapelin-13effectsontraumaticbraininjury-inducedneuralcelldeathandblood-brainbarrierintegrityarestillnotclear.Here,wefoundthatapelin-13significantlydecreasescerebralwatercontent,mitigatesblood-brainbarrierdestruction,reducesaquaporin-4expression,diminishescaspase-3andBaxexpressioninthecerebralcortexandhippocampus,andreducesapoptosis.Theseresultsshowthatapelin-13attenuatessecondaryinjuryaftertraumaticbraininjuryandexertsaneuroprotectiveeffect.

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简介：大脑是处于正常条件的一个immunologically给予优惠的地点，这长被知道了。尽管只要有neuronal损害或有势力免疫者刺激，有免疫力的回答的串联能发生，大脑怎么把glial房间放在一个静止状态，仍然是不清楚的。增加的努力被几作了实验室阐明有免疫力的回答的压抑怎么在neuronal环境被完成。抑制因素经由粘附分子或CD200受体包括neurotransmitters，神经激素，神经营养的因素，反煽动性的因素，和房间房间接触。因为上面列出的单个因素都不能充分说明有免疫力的抑制，这评论讨论这些因素怎么影响服的有免疫力的回答的串联。当几个因素贡献有免疫力的回答的抑制时，只要有neuronal损害，glial房间和他们支持inflammatory因素的生产的激活确实发生，建议一些neuronal部件便于有免疫力的回答。这评论也讨论信号哪个开始或扩充服的有免疫力的回答以便stimulatory信号制服镇压信号。证据的增加的线证明了在大脑的有免疫力的回答不对神经原总是有害。简单地在CNS变清离开煽动性的因素的尝试不能为在神经病学的混乱的神经原是适当的。在CNS的有免疫力的房间的适当控制可能对神经原或甚至neuroregeneration有益。因此，理解位于有免疫力的抑制下面的机制可以帮助我们在许多神经病学的混乱对发炎重塑药理学干预。

简介：Objective:Toobservepsychologicalchangesofthearmedpolicemenunderstressstateandtheeffectofacupunctureinterventionforexploringpossiblemeasuresinraisingthearmedpolicemen'scapabilityindealingwiththesuddenly-occurredaccidents.Methods:Inthefirstpartofthestudyforobservingpsychologicalchanges,atotalof90volunteerarmedpolicemenparticipatinginanti-terrorismmaneuverwererandomlyandevenlydividedintoanti-chemicalweapongroup,flightreconnaissancegroupandhostage-rescuinggroup.30logisticpersonalswereselectedtoformcontrolgroup.SymptomChecklist-90(SCL-90)questionnairewasusedtoassessthepsychologicalstateoftheseanti-terrorismpolicemen.Inthesecondpartofthestudyforobservingtheeffectofacupuncture,60policemenwithanxietyanddepressionwhoweredeterminedbySelf-RatingDepressionScale(SDS)andSelf-RatingAnxietyScale(SAS)wererandomlyandevenlydividedintonon-acupunctureandacupuncturegroups,andother30policemenwithnormalpsychologicalstatewereselectedtoformcontrolgroup.Twoweeksbeforeanti-terrorismmaneuver,participantsofacupuncturegroupwereaskedtoreceivecontinuousacupuncturetreatmentofbilateralNeiguan(内关PC6)andZusanli(足三里ST36),oncedaily,15mineverytime.Results:Comparisonamongthefirst4groupsdisplayedthatthetotalscores,scoresofbodyfeelingreactions,interpersonalrelation,depression,anxiety,terror,andpsychologicalproblemsofflightreconnaissanceandhostage-rescuinggroupsweresignificantlyhigherthanthoseofcontrolgroup(P<0.05～0.01),suggestingthatthepsychologicalstresspressurewasstrongestinflightreconnaissancepolicemenandsecondaryinhostage-rescuingpolicemen,followedbyanti-chemicalweaponpolicemen.Followingadministrationofacupunctureintervention,scoresofbothSDSandSASinacupuncturegroupwereconsiderablylowerthanthoseofnon-acupuncturegroup(P<0.01),showingthatacupunctureinterventioncouldreducepsyc

简介：BackgroundSeveralstudieshavereportedanassociationofhyperglycemiawithincreasedmortalityandcomplicationsinhospitalpatientswithacutecoronarysyndrome(ACS).However,theinfluenceofstresshyperglycemia(SH)onthemedium-andlong-termprognosesinACSpatientshasnotyetbeendetermined.MethodsRandomvenousbloodglucoselevelsweredeterminedin433ACSpatientsandthepatientsweredividedintotwogroupsbasedonbloodglucoseresultsanddiseasehistories.The171patientsincludedintheexperimentalgrouphadnohistoryofdiabetes,hadnodiabetesand/orglucosemetabolismdisordersduringhospitalizationandfollow-upandhadfastingbloodglucoselevelsof≥7.0mmol/Landrandombloodglucoselevels≥11.1mmol/L.The262patientsincludedinthecontrolgrouphadnohistoryofdiabetes,hadnodiabetesand/orglucosemetabolismdisordersduringhospitalizationandfollow-up,andhadfastingbloodglucoselevels<6.1mmol/Landrandombloodglucoselevels<7.8mmol/L.Basicclinicalinformation,coronaryangiographiclesioncharacteristics,PCIsuccessrate,complicationrate,incidenceandmorbidityrateofcardiovasculareventsduringthehospitalizationperiodand6yearsoffollow-upwerecomparedbetweenthetwogroups.ResultsTherewasnosignificantdifferenceinage,genderordiseasehistorybetweenthetwogroups.Thetriglyceridelevelsandtheleftventricularejectionfractionsweresignificantlyhigher(P=0.00)andsignificantlylower(P=0.03)intheexperimentalgroupthaninthecontrolgroup,respectively.BothgroupsweresubjectedtocoronaryangiographyandPCI.ThePCIsuccessratesofthetwogroupsdidnotdiffersignificantly(P=0.63).TheexperimentalgrouphadmoretypeB2lesions,butfewertypeAlesionscomparedwiththecontrolgroup.Theexperimentalgrouphadsignificantlymorestentsimplantedcomparedwiththecontrolgroup(P<0.05).Thecardiovasculareventsweresignificantlyincreased(P=0.01)intheexperimentalgroupcomparedwiththecontrolgroup1yearafterdischarge.Thein

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