简介：Theeffectsofexerciseondecision-makingperformancehavebeenstudiedusingawidevarietyofcognitivetasksandexerciseinterventions.Althoughthecurrentliteraturesupportsabeneficialinfluenceofacuteexerciseoncognitiveperformance,themechanismsunderlyingthisphenomenonhavenotyetbeenelucidated.Wereviewstudiesthatusedsingle-pulsetranscranialmagneticstimulation(TMS)toprobetheexcitabilityofmotorstructuresduringwhole-bodyexerciseandpresentaframeworktoaccountforthefacilitatingeffectsofacuteexerciseonmotorprocesses.Recentresultssuggestthat,evenintheabsenceoffatigue,theincreaseincorticospinalexcitabilityclassicallyreportedduringsubmaximalandexhaustingexercisesmaybeaccompaniedbyareductioninintracorticalinhibition.Weproposethatreducedintracorticalinhibitionelicitsanadaptivecentralmechanismthatcounteractstheprogressivereductioninmuscleresponsivenesscausedbyperipheralfatigue.Suchareductionwouldrenderthemotorcortexmoresensitivetoupstreaminfluences,thuscausingincreasedcorticospinalexcitability.Furthermore,reductionofintracorticalinhibitionmayaccountforthemoreefficientdescendingdriveandfortheimprovementofreactiontimeperformanceduringexercise.Theadaptivemodulationinintracorticalinhibitioncouldbeimplementedthroughageneralincreaseinreticularactivationthatwouldfurtheraccountforenhancedsensorysensitivity.

简介：AIM:Toinvestigatetheefficacyandsafetyofkryptonlaserperipheraliridoplasty(LPIP)forChinesepatientswithprimaryangleclosure(PAC)orprimaryangle-closureglaucoma(PACG)statuspostlaseriridotomyinreversingthepositiveresultsofthedarkroomprovocativetest(DRPT).METHODS:Thisstudywasprospective,noncomparative,interventionalcaseseries.Thirty-threepatients(thirty-eighteyes)withPACorPACGstatuspostpatentlaseriridotomyandmaintainednormalintraocularpressure(IOP)butwithpositiveDRPTresultswereenrolled.AllthesubjectsweretreatedwithkryptonLPIP.DRPTwasrepeatedafterkryptonLPIP.ResultsofDRPTwererecorded.Thevisualacuity,IOPandgonioscopywereanalyzedbeforeandafterkryptonLPIP.Aminimumtimelimitforfollow-upwas6mo.RESULTS:Thirty-threepatients(thirty-eighteyes)werefollowedfor17.7±8.37mo(range7-41mo)afterLPIP.PositiveresultsofDRPTdecreasedfrom38eyesto9eyes(23.7%)afterLPIP.Peripheralanteriorsynechiaeofanglein34of38eyes(89.5%)remainedunchangedatdynamicgonioscopythroughoutthefollow-upperiodafterLPIP.CONCLUSION:LPIPdecreasedpositiveratesoftheDRPTsignificantly.ThemechanismmaybethatLPIPminimizedcontactbetweentheperipheralirisandtrabecularmeshwork,whichisakeyfactorfordevelopingperipheralanteriorsynechiae.