简介：Inthepresentstudy,theeffectofblockageofthecostimulatorysignalCD86attimeofimplantationontheexpressionsofTGF-β1,MMP-9,TIMP-3andPAI-1proteinsatthematernal-fetalinterfaceandtheoutcomeofpregnancyinmurineabortion-pronemodelwasinvestigated,inwhichtheCBA/JxDBA/2matingswereusedastheabortion-pronemodelandtheCBA/J×BALB/cmatingsusedasthenormalpregnantmodel.Thestudywasperformedinfollowingthreegroups:2groupsoftheabortion-pronemodel,whichwereexperimentalgroupandcontrolexperimentalgroup,and1groupofnormalpregnantmodel,andeachgrouphad10pregnantCBA/Jmiceexclusively.FemalepregnantCBA/Jmiceintheexperimentalgroupreceivedanintraperitoneal(i.p.)injectionof100μgofantimouseCD86mAbin200μlofPBSatday4.5ofgestation,andtheirrelevant-isotopematchedratIgG2bwasadministratedinthecontrolexperimentalgroupwiththesamedosageandatsametime.Forthenormalpregnantgroup,notreatmentwasgiven.ThepregnantCBA/Jmicewerekilledonday13.5ofgestation.Then,theembryoresorptionratewascalculatedandtheexpressionsofTGF-β1,MMP-9,TIMP3andPAI-1weredetectedbyusingimmunohistochemicalmethods.Itwasdemonstratedthattheembryoresorptionrateintheexperimentalgroupwassignificantlyreducedincomparisonwiththatinthecontrolexperimentalgroup(x2=7.441,P=0.006),buttherewasnosignificantdifferencewiththatinnormalpregnantgroup(x2=0.016,P=0.898).TheexpressionsofTGF-β1andPAI-1intheexperimentalgroupweresignificantlyincreasedincomparisonwiththatinthecontrolexperimentalgroup(P=0.010,P=0.003,respectively),withnosignificantdifferencefromthatinthenormalpregnantgroup(P=0.500).However,theexpressionofMMP-9intheexperimentalgroupwassignificantlyreducedincomparisonwiththatinthecontrolexperimentalgroup(P=0.012)withnosignificantdifferencefromthatinthenormalpregnantgroup(P=0.500).Theexpression

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简介：摘要：总结1例TACE术后脊髓损伤的中西医康复护理。重点是加强病情观察，及时发现患者脊髓损伤，一旦发现患者出现脊髓损伤，按医嘱做好药物治疗的护理，给予心理护理同时促进患者功能康复。本例患者经过治疗与中西医康复护理，神经系统症状逐渐恢复后出院。

简介：一、病情摘要

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简介：【摘要】 患者确诊为非霍奇金淋巴瘤时，难免会出现各种应激反应，导致心理负担加重，直接影响临床配合度及治疗效果。本个案从认知干预、团体心理辅导的角度阐述非霍奇金淋巴瘤患者的心理护理，旨在为患者提供全程、专业、人性化、个体化的护理服务。

简介：Inthepastdecade,usesofantisepticsanddisinfectantsinhospitalsandotherhealthcarecentersarerathercommon,butthechancetodevelopresistancetoantisepticsanddisinfectantsisalsoincreased.Acinetobacterbaumanniiisoneoftheopportunisticbacteriainvolvinginthenosocomialinfection.Inthepresentstudy,thecorrelationoftheantisepticresistanceinA.baumanniiandtheantisepticresistancegeneqacEΔ1wasinvestigatedbymeansofdeterminationofMICs.Meanwhile,theMICsofglutaraldehyde,chlorhexidine,benzalkoniumbromide,iodophorandtrichloroisocyanurateto80clinicalisolatesofA.baumanniiweredetectedbytubedilutionassayandtheresistancegenesintI1andqacEΔ1intheseisolateswereamplifiedbyPCRandverifiedbyDNAsequencer.ItwasfoundthattheMIC50forthese5antisepticstestedwere32,8,8,4and1μg/mlrespectively,andthedetectionratesofintI1andqacEΔ1genewere60.0%and77.6%respectively.Inaddition,55%ofthe80isolatessimultaneouslypossessedbothintllandqacEΔ1gene,andthepercentageofantisepticresistanceofA.baumanniicarringbothgenestobenzalkoniumbromidewerehigherthanthatwithoutthesetwogenes,however,therewasnosignificantdifferencebetweenintllandqacEΔ1gene.Theresultinbactericidalefficiencyassayindicatedthatchlorhexidinecouldstillproducerapidandstrongbactericidaleffectatconcentrationof1MICafter10minexposure.TheseresultssuggestthattheantisepticresistanceofA.baumanniitovariousantisepticsiscorrelatedwiththepresenceoftheantisepticresistancegenesqacEΔ1inbacteria,thuswarningthattheincreaseoftheantisepticresistanceshouldnotbeignoredandtherelativehighconcentrationorprolongedapplicationtimeisrequiredtoachieveasufficientbactericidaleffect.

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简介：【摘要】报告 1例室上速患者使用改良瓦氏动作的急救护理。护理要点包括：快速识别与评估、心理护理、改良瓦氏动作实施、健康教育。经过改良瓦氏动作的实施患者 2 分钟即成功复律。

简介：【摘要】：目的：研析在急诊内科的治疗中，给与不同的药物治疗对老年重症心力衰竭患者的临床参考价值。方法：选取老年重症心力衰竭患者80例，均为我院收治，随机原则均分为A组及B组，对A组患者行常规治疗，对B组行美托洛尔联用厄贝沙坦氢氯噻嗪治疗，对两组患者的临床治疗治疗前后的心功能指标进行分析。结果：治疗前两组患者心功能并无较大差异（P＞0.05）；治疗后，B组患者的心功能改善效果较A组更为显著（P＜0.05）。结论：对于急诊内科的老年重症心力衰竭患者采用美托洛尔联用厄贝沙坦氢氯噻嗪治疗，患者症状显著缓解，疗效可观。

简介：【摘 要】目的：总结皮脂腺痣患者的围手术期护理干预措施。方法：选择 2019年 2月 18日于本院接受治疗的 1例皮脂腺痣患者，对其围手术期护理干预措施进行总结和分析。 结果：患者经过围手术期的护理，疾病痊愈、患者及家属满意度达100%。 结论：加强皮脂腺痣患者的围手术护理、健康教育、饮食干预，在促进疾病恢复中具有重要意义，值得重视。

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简介：InordertorevealvariationandrevolutionofNPgenesofhumanavianH_5N_1influenzavirusstrains,theNPgeneofahumanavianH_5N_1influenzavirusstraininGuangdongwassequencedandtheglobalNPgenesofstrainswereretrieved.ThesequenceswereanalyzedbyDNAStar5.0,andtheevolu-tionaryspeedwasstudiedwithreferencetotheepidemiologicaldata.ItwasfoundthatNPgenesof45strainsduring1997-2006werehomologicallyclassifiedintothreegroups:strainsin1997-1998,strainsin2004-2005andstrainsfrom2003to2006.Therewere35substitutionsinNPsinallstrainsaccountingforaratioof7.03%(35/498).Anadditionalglycoproteindomain(NGT_(430-432))wasfoundinNPgenesinthestrainsof2003-2006,themutationofN_(370)SinGD-01-06resultedinoccurrenceofonemoreglyco-proteindomain(NES_(368-370)).Inthesynonymousvariation,K_svaluesinNPwere2.03×10~(-5)-2.55×10~(-5)Nt/dandK_avaluesinNPwere1.58×10(-6)-3.10×10~(-6)Nt/d.Theredidn′texistobviouslyselectivepres-sure.Anadditionalglycoproteindomainineverystrainof2003-2006andonemoreinstrainGD-01-06mightchangetheantigenicityofhumanavianH_6N_1influenzavirus.ThevariationonhumanavianH_5N_1influenzastrainsoccurredfrequentlyinthenaturalworld,whichwouldresultinhighprobabilityofhu-man-humantransmissionalongwiththenaturalevolutionofthevirus.

简介：Wereportedanovelmammalianreovirus,designedBYD1,isolatedfromthroatswabsofpatientswithsevereacuterespiratorysyndrome(SARS),in2003.Inthepresentstudy,wefirstlycomparedthegenomeelectrophoreticmigrationpatternsofreovirusBYD1with3prototypereovirusstrainsbypolyacrylamidegelelectrophoresis(PAGE)anddeterminedthecompletenucleotidesequenceoftheS1genesegmentofBYD1bysingleprimeramplificationtechnique.TheelectropherogramofBYD1wasdifferentfromthoseofthe3prototypestrainsandanyotherreovirusisolatesreportedbefore.TheentireS1segmentsequenceofBYD1is1437bplongwithtwomeaningfulopenreadingframes(ORFs).ThelongestORFencodesσ1,thecellattachmentprotein,andthesecondlongestORFsupposedlyencodesσ1s,animportantnonstructuralvirulencefactor.TheterminalsequencesofS1segmentare5'GCUAand3'UCAUC,whichareconsistentwiththoseofothermammalianreoviruses.Thehighesthomologyofdeducedσ1aminoacidsequenceis64%identitywithknownmammalianreoviruses.PhylogeneticanalysisofbothS1nucleotidesequenceandσ1aminoacidsequenceindicatedtheBYD1isolatebelongedtoanewcladeofserotype2group.TheresultsofthisstudyshowedthattheBYD1S1segmentwasmarkedlydifferentfromthoseofisolatesreportedbeforeandBYD1wasanovelhumanreovirusisolate.

简介：【摘要】1例50岁男性患者直肠癌术后行FOLFOX化疗方案后2月余，因空蝶鞍检查视野发现双眼视野缺损，眼科相关检查未发现异常。停药后3个月视野恢复正常。

简介：摘要：目的：观察PDCA循环应用于口腔门诊护理管理的临床效果。方法：随机分组，对照组使用常规护理管理方法，观察组使用PCDA循环护理管理方法。结果：观察组对医院环境评分为（92.36±1.58）分、医疗器械评分为（94.15±1.69）分、安全意识评分为（97.00±2.33）分、护理态度评分为（90.41±2.30）分，观察组满意度为97.7%（42/43），与对照组差异显著（P＜0.05）。结论：将PCDA循环应用于口腔门诊护理中，具有明显的效果，可以为患者提供良好的服务环境，使患者在就诊中感到舒适，利于医院可持续发展，应在护理过程中广泛推广。

简介：[ 摘要 ] 报告 1 例原发性皮肤弥漫大 B 细胞淋巴瘤，腿型。患者男， 69 岁，司机，右小腿肿物半年，泛发四肢 3 周，伴溃烂 1 周。皮肤组织病理活检：真皮及皮下组织可见广泛的肿瘤细胞浸润。肿瘤细胞核大、嗜碱、异性，呈圆、椭圆、多角、腰果状多种形态。可见核仁，胞浆少，分裂像多见。免疫组化： CD20 （ + ）， CD79a （ + ）， AE1 /AE3(—) ， S100(—) ， HMB-45(—) ， CD34(—) ， CD3(—) ， CD5(—) ， PAX-5(+) ， Bcl-6(—) ， CD10(—) ， HUM-1(—) ， Ki-67 （约 70% ）。

简介：摘要：总结 1 例腹腔镜术后持续性异位妊娠的护理体会，护理要点包括生命体征的观察，心理护理，用药护理。通过用药治疗后，患者治愈。