简介:AIM:Toinvestigatethepossiblerelationshipbetweentheinfluencingfactorsoccurringbeforeandduringbirthinfull-terminfantsandtheoutcomeofretinopathy.·METHODS:Totally816full-terminfantsadmittedintheneonateintensiveunitofBoaiHospitalofZhongshanbetween1May,2008and30June,2011wereincludedinthestudy.Fundusexaminationwasperformedandevaluatedindividuallyonthemattheageof48hoursafterdelivery,2weeksand1month.Somepossibleriskfactorshappeningprenatallyorduringdeliverysuchaspregnantrelatedhypertension,placentaprevia,placentalabruptionetc,aswellassomeneonatalriskfactorssuchasneonatalasphyxia,hypoxic-ischemicencephalopathy(HIE),lowbirthweightetc,wererecordedandevacuated.Thentheeffectoftheriskfactorsoffull-terminfantsonretinopathywasstudied.·RESULTS:Theincidenceofretinalhemorrhageoffull-terminfantswithprenatalpregnantrelatedhypertension(PRH)ofthemother(43.6%)wassignificantlyhigherthanthatoffull-terminfantswithout(8.0%).(P<0.001).Theincidenceofretinalhemorrhageoffull-terminfantswithneonatalasphyxiaand/orhypoxic-ischemicencephalopathy(HIE)(29.3%)wassignificantlyhigherthanthatofthosewithout(15.7%),butcorrelationwasnotfoundbetweentheseverityofretinahemorrhageandthedegreeofhypoxicdisease.Apalecolorofopticdiscwasassociatedwithalowbirthweightoffull-terminfant.Full-terminfantswithbirthweighlessthan2500ghadasignificanthigherincidenceofretinopathythanthosewithbirthweightequalormorethan2500g(P<0.001).·CONCLUSION:Themaininfluencingfactorswhichleadtoretinopathyofhighriskfull-terminfantsareprenatalfactorssuchasPRH,andsomeneonatalriskfactorssuchasasphyxia,hypoxic-ischemicencephalopathy,andlowbirthweight.
简介:目的对比研究单切口与双切口青白联合手术治疗青光眼合并白内障的疗效。方法采用临床随机对照研究。选取52例(52眼)青光眼合并白内障患者随机分成两组:单切口组(白内障超声乳化联合人工晶体植入术和小梁切除术经同一切口完成)和双切口组(上方巩膜切口行小梁切除术和透明角膜切口行白内障超声乳化联合人工晶体植入术),每组各26例(26眼)。术后随访3个月6个月和12个月,比较两组患者眼压控制情况及视力情况。结果本研究最终完成随、访资料47例,其中单切口组23例和双切口组24例纳入分析。两组术后眼压均较术前明显降低,差异3个月、6个月和12个月有统计学意义(P<0.05);两组间术后3个月、6个月和12个月的眼压下降量比较,差异无统计学意义P=0.52,0.38和0.47)。两组间术后3个月、6个月和12个月的视力比较,差异无统计学意义(x2=0.789,x2=0.374;x2=0.007,x2=0.932;x2=0.537,P=0.464)。结论单切口与双切口青白联合术均可安全、有效治疗青光眼合并白内障,两种术式具有相似疗效。
简介:目的:评价七叶洋地黄双苷滴眼液治疗近视患者准分子激光原位角膜磨镶术(1aseffnsitukeratomileusis,LASIK)后视疲劳的临床疗效。方法:对200例400眼近视患者行LASIK手术,随机分成两组。100例为试验组应用七叶洋地黄双苷滴眼液,另100例为对照组应用潇莱威滴眼液。分别于手术前、用药后1,2,4wk评估患者术后视疲劳的症状和体征,同时观察药物不良反应。结果:随着术后时间的延长,试验组和对照组近视患者视疲劳症状逐渐缓解,在术后1,2wk时,试验组的视疲劳评分低于对照组,两组差异有统计学意义(t=3.160,P=0.001;t=2.727,P=0.0025);术后4wk时,两组的差异无统计学意义(t=1.423,P=0.10)。结论:随着观察时间的延长,LASIK术后患者视疲劳症状可逐渐得到恢复和改善,七叶洋地黄双苷滴眼液对改善LASIK术后早期视疲劳症状有效。
简介:目的:观察双撕囊联合前部玻璃体切除治疗先天性白内障的疗效。方法:对31例52眼2月龄~12岁先天性白内障患儿实行白内障囊外摘除、后囊连续环形撕囊、前部玻璃体切除术,联合Ⅰ期或Ⅱ期IOL植入,平均随访16mo。结果:31例患儿之中有27例44眼术后能检查视力,最佳矫正视力〉0.5者23眼,〉0.3者12眼,〈0.3者9眼,另外,〈2岁的患儿4例8眼无法进行视力表检查,但相对术前跟随光亮或有注视目标的能力有所提高。术后并发症:后发性白内障3眼、葡萄膜炎7眼、角膜水肿5眼,人工晶状体偏位、黄斑囊样水肿、视网膜脱离等严重并发症尚未出现。结论:双撕囊联合前部玻璃体切除术联合IOL植入能预防后发性白内障等并发症的发生,是比较安全有效的治疗儿童先天性白内障的手术方式。
简介:目的:利用DNA探针杂交技术,结合显色探针技术建立一种新型、高灵敏的免疫检测体系,用于早期先天性白内障的筛查。方法:选取3个常染色体显性遗传的先天性白内障家系中患者14例,取静脉血并提取mRNA,建立CRYAB的捕获探针及显色探针。利用DNA探针,通过碱基配对原则形成三明治结构(捕获探针-DNA探针-显色探针)检测入选者的血样。1家系6例患者静脉血利用酶联免疫吸附测定(ELISA)法检测琢B-晶状体蛋白。结果:最佳条件下,双特异探针技术可检测到最低浓度的先天性白内障晶状体蛋白的突变基因,各突变位点检测率为99.5%~99.7%;ELISA法检测样本琢B-晶状体蛋白上调,阳性率为85.9%。双特异探针技术敏感性更高,检测位点更多,ELISA法仅局限于蛋白检测水平,精确性不高。结论:双特异探针检测技术操作简单,灵敏度高,可重复性高,经济实惠,在临床上用于产前诊断、优生优育具有重要的应用价值。
简介:目的评价庆大霉素双氯芬酸钠控制白内障和青光眼术后炎症反应的疗效和安全性。方法采用临床多中心、随机、双盲、对照试验。试验组和对照组分别滴用庆大霉素双氯芬酸钠和复美新,每日4次,观察2wk。结果内眼术后试验组和对照组中有效率分别是71.43%和65.52%,两者间的差异无统计学意义。两组的不良事件发生率也无统计学意义。结论庆大霉素双氯芬酸钠是控制内眼术后(白内障手术和青光眼手术)有效和安全的药物。(中国眼耳鼻喉科杂志,2006,6:223~225)
简介:目的观察七叶洋地黄双苷滴眼液(施图伦)对青少年低度数近视及视疲劳症状的治疗效果。方法收集于2015年6月至9月就诊于浙江省台州医院眼科门诊的青少年近视患者120例240眼,根据用药情况不同随机分为对照组,托吡卡胺组,施图伦组,每组40例80眼,分别比较三组用药前与用药后一月的裸眼视力与屈光状态,根据视疲劳问卷调查表评估用药前后的视疲劳症状变化。结果(1)裸眼视力:施图伦组及托吡卡胺组较治疗前裸眼视力均有一定程度提高,差异有统计学意义(P〈0.05)。(2)近视度数:施图伦组较治疗前矫正度数下降,差异有统计学意义(P〈0.05),托吡卡胺组矫正度数较治疗前有下降,差异有统计学意义(P〈0.05)。对照组矫正度数较治疗前对比无差异。(3)视疲劳症状:施图伦组视疲劳症状改善37例,总改善率达92.5%。对照组及托吡卡胺组对比治疗前差异无统计学意义。结论施图伦滴眼液能显著改善近视患者的视疲劳症状,对于低度数近视有一定的治疗作用。
简介:AIM:Toevaluatetheaccuracyofsphericalequivalent(SE)estimatesofadouble-passsystemandtocompareitwithretinoscopy,subjectiverefractionandatablemountedautorefractor.METHODS:Non-cycloplegicrefractionwasperformedon125eyesof65healthyadults(age23.5±3.0years)fromOctober2010toJanuary2011usingretinoscopy,subjectiverefraction,autorefraction(AutokeratorefractometerTOPCONKR-8100,Japan)andadoublepasssystem(OpticalQualityAnalysisSystem,OQAS,VisiometricsS.L.,Spain).Nineconsecutivemeasurementswiththedouble-passsystemwereperformedonasubgroupof22eyestoassessrepeatability.ToevaluatethetruenessoftheOQASinstrument,theSElaboratorybiasbetweenthedoublepasssystemandtheothertechniqueswascalculated.RESULTS:TheSEmeancoefficientofrepeatabilityobtainedwas0.22D.SignificantcorrelationscouldbeestablishedbetweentheOQASandtheSEobtainedwithretinoscopy(r=0.956,P<0.001),subjectiverefraction(r=0.955,P<0.001)andautorefraction(r=0.957,P<0.001).ThedifferencesinSEbetweenthedouble-passsystemandtheothertechniquesweresignificant(P<0.001),butlackedclinicalrelevanceexceptforretinoscopy;Retinoscopygavemorehyperopicvaluesthanthedouble-passsystem-0.51±0.50Daswellasthesubjectiverefraction-0.23±0.50D;Moremyopicvalueswereachievedbymeansofautorefraction0.24±0.49D.CONCLUSION:Thedouble-passsystemprovidesaccurateandreliableestimatesoftheSEthatcanbeusedforclinicalstudies.Thistechniquecandeterminethecorrectfocuspositiontoassesstheocularopticalquality.However,ithasarelativelysmallmeasuringrangeincomparisonwithautorefractors(-8.00to+5.00D),andrequirespriorinformationontherefractivestateofthepatient.