简介：Differentsystemshavebeenusedovertheyearstodeliverdrugparticlestothehumanskinforpharmaceuticaleffect.Researchhasbeendonetoimprovetheperformanceandflexibilityofthesesystems.Inrecentyearsauniquesystemcalledthetransdermaldrugdeliveryhasbeendeveloped.Transdermaldrugdeliveryopenedanewdoorinthefieldofdrugdeliveryasitismoreflexibleandoffersbetterperformancethantheconventionalsystems.Theprincipleofthissystemistoacceleratedrugparticleswithahighspeedgasflow.Amongdifferenttransdermaldrugdeliverysystemswewillconcentrateonthecontourshocktubesysteminthispaper.Acontouredshocktubeisconsistsofarupturechamber,ashocktubeandasupersonicnozzlesection.Thedrugparticlesareretainedbetweenasetofburstingdiaphragm.Whenthediaphragmisrupturedatacertainpressure,ahighspeedunsteadyflowisinitiatedthroughtheshocktubewhichacceleratestheparticles.Computationalfluiddynamicsisusedtosimulateandanalyzetheflowfield.TheDPM(discretephasemethod)isusedtomodeltheparticleflow.AsanunsteadyflowisinitiatedthoughtheshocktubethedragcorrelationproposedbyIgraetalisusedotherthanthestandarddragcorrelation.Theparticlevelocitiesatdifferentsectionsincludingthenozzleexitareinvestigatedunderdifferentoperatingconditions.Staticpressurehistoriesindifferentsectionsintheshocktubeareinvestigatedtoanalyzetheflowfield.Theimportantaspectsofthegasandparticledynamicsintheshocktubearediscussedandanalyzedindetails.

简介：与黄金和氧化铁nanoparticles并且与silibinin装载的PEGylated-PLGA随机的nanofibrous膜被electrospinning免职准备。nanofibrous膜能遥远地被控制并且由一盏激光灯或磁场激活在需求上释放生物代理人。nanosystems用扫描电子显微镜学被描绘，红外线的光谱学，原子磁性的回声光谱学，和thermogravimetric分析的Fourier变换。装载效率和药内容百分比的药被紫外力的光吸收光谱学决定。nanofibrous膜由相对低紧张的激光照耀或由一个磁场刺激了为至少60h显示出持续silibinin版本，没有爆炸效果。建议便宜electrospinning过程能够集合，经由一个一步舞过程，有外部地为控制的药交货要激活的金属性的nanoparticles的刺激应答的装载药的nanosystem。