简介：Lymphomararelyoccursduringpregnancy,makingthisconditiondifficulttodefine.Lymphomasthatoccurinreproductiveorgansduringpregnancyexhibituniqueclinicalcharacteristics.Amongthelimitedcases,non-Hodgkin'slymphoma(NHL)showsaconsiderablyhigherincidenceratethanHodgkin'slymphoma(HL);NHLalsodisplaysclinicalcharacteristics,suchashighaggressiveness,advancedstage,andpooroutcome.Thisstudyreportsonfourcasesoflymphomasinnon-gonadalorgans(HL,n=2;NHL,n=2)duringpregnancy.Thetumorsrapidlyprogressedinallpatientsduringpregnancybutremittedattheendofpregnancyand/ortherapy.ThetwoHLcaseswerenodularsclerosisclassicalHLandtreatedwithchemotherapyafterterminatingthepregnancy.OneoftheNHLcaseswasprimarycutaneousfollicularcenterlymphoma,aBcell-derivedindolentlymphoma.Thepatientwasfollowedupwithoutanytherapyafterterminatingherpregnancy.Theothercasewasafollicularlymphomagrade3B,whichwastreatedwithchemotherapyafterdelivery.Wealsoconductedaliteraturereviewof165lymphomacasesoccurringduringpregnancyreportedfrom1976to2013torevealthecorrelationbetweenpregnancyandlymphomaprogression.Immunohistochemistrystudieswereperformedtodeterminetheexpressionofestrogen/progesteronereceptors(ER/PR),andERwasweaklypositiveandsporadic.Weconcludedthatlymphomasoccurringduringpregnancyshouldbemanagedwithapromptandreasonabletreatment.Highestrogenlevelinmaternalbodymayaffectlymphomaprogression.

简介：Objective:Tocomparethemechanismsofanalgesiainducedbyfourkindsofacupuncturetherapiesatthehypothalamiclevelinadjuvantarthriticrats.Methods:Forty-eightSDratswererandomizedintonormal,model,electroacupuncture(EA),filiformneedle(FN),prickingblood-letting(BL)andpointinjection(PI)groups,with8casesineach.EA(20-100Hz,2-4Vanddurationof20min),FN,BLPIwererespectivelyappliedto"Kunlun"(昆仑BL60).ArthritismodelwasestablishedbyinjectingcompleteFreund'sadjuvant(0.1mL)intotherat'srightfootpad.Behavioralreactions,painthreshold(latencyoftailflicktoheatstimulation)andlocalswellingseverity(footvolume)weredetected;thecontentsofβ-endorphin(β-EP)andadrenocorticotropin(ACTH)wereassayedwithradioimmunoassay;andtheexpressionofpro-opi-omelanocortin(POMC)mRNAinhypothalamusweredeterminedwithhybridizationmethod.Results:Thepainthresholdwassignificantlyenhancedbyallthefourkindsofacupuncturetherapies,andtheeffectsofEAandPIweremoreobvious(P<0.05,P<0.01).Theseverityoflocalswellingwasmarkedlyalleviatedbyallthefourkindsofacupuncturetherapies(P<0.01)withoutsignificantdifferencesamongthem(P>0.05).Thecontentofβ-EPinthehypothalamuswasobviouslyelevatedbyEAandFN(P<0.05,P<0.01),andtheeffectofEAwasmoreobvious,butnomarkedeffectofBLorPIonβ-EPwasfound(P>0.05).ThecontentofACTHinhypothalamuswasconsiderablyelevatedbyPI(P<0.05),butnotbytheotherthreetherapies.TheexpressionofPOMCmRNAinhypothalamuswassignificantlystrengthenedbyEAandFN(P<0.01),butnotbytheothertwotherapies.Conclusion:EA,filiformneedle,blood-lettingandpoint-injectionallcanproduceanalgesiceffectinadjuvantarthritisrats,theeffectofEAandfiliformneedlemayberelatedtotheirresultantincreaseofhypothalamicβ-EP,andthatofpoint-injectionrelatedtotheincreaseofhypothalamicACTHlevel.

简介：Poriacocos(Schw.)Wolf,animportantmedicinalandfoodfungus,iswellknowninEastAsia.Duetogrowingmarketdemand,longcultivationperiod,andconsumptionofpinetrunkduringcultivation,developingalternativemethodsforproducingP.cocosand/oritsactivecomponentsisofinterest.Inthepresentstudy,theeffectsofdifferentculturemethodsonbiomassandaccumulationoffourtriterpenoidswereinvestigated.Theethanolextractoffermentedmycelium(EFM)wasorallyadministeredtorats.Urineoutputandconcentrationsofelectrolytes(Na~+,K~+,andCl~-)weremeasured.Ourresultsshowedthatmyceliagrewbetterundercontinuousshakingculturecondition(7.5gDW·L~(-1)),andhighertriterpenoidlevelswereaccumulatedintwo-stageculture(112mg·L-1,2.03%).Theoptimalstartingtimeofstaticculturefortriterpenoidyieldwas4~(th)daftershakingculture.SingleadministrationofmiddleandhighdoseofEFMsignificantlyincreasedurineoutput,Na~+andCl~-excretion,andNa~+/K~+ratio.Theseresultssuggestedthatethanolextractofculturedmyceliashowedsignificantdiureticactivityinratsandtwo-stagecultureofP.cocoscouldbeanalternativewaytoproducemyceliaandtriterpenoids.

简介：Objective:VitaminDreceptor(VDR)mediatesvitaminDactivity.WeexaminedwhetherVDRexpressioninexcisedmelanomatissuesisassociatedwithVDRgene(VDR)polymorphisms.Methods:WeevaluatedVDRproteinexpression(bymonoclonalantibodyimmunostaining),melanomacharacteristics,andcarriageofVDR-FokI-rs2228570(C>T),VDR-BsmI-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),andVDR-TaqI-rs731236(T>C)polymorphisms(byrestrictionfragmentlengthpolymorphism).Absenceorpresenceofrestrictionsitewasdenotedbyacapitalorlowerletter,respectively:'F'and'f'forFokI,'B'and'b'forBsmI,'A'and'a'forApaI,and'T'and't'forTaqIendonuclease.Seventy-fourItaliancutaneousprimarymelanomas(52.1±12.7yearsold)werestudied;51.4%werestageⅠ,21.6%stageⅡ,13.5%stageⅢ,and13.5%stageⅣmelanomas.VDRexpressionwascategorizedasfollows:100%positivevs.<100%;overthemedian20%(highVDRexpression)vs.≤20%(lowVDRexpression);absencevs.presenceofVDR-expressingcells.Results:StageImelanomas,Breslowthicknessof<1.00mm,levelIIClarkinvasion,Aaheterozygousgenotype,andAaTTcombinedgenotypeweremorefrequentinmelanomaswithhighvs.lowVDRexpression.CombinedgenotypesBbAA,bbAa,AATt,BbAATt,andbbAaTTweremorefrequentin100%vs.<100%VDR-expressingcells.CombinedgenotypeAATTwasmorefrequentinmelanomaslackingVDRexpression(oddsratio=14.5;P=0.025).VDRexpressionwasnotassociatedwithmetastasis,ulceration,mitosis>1,regression,tumor-infiltratinglymphocytes,tumoralinfiltrationofvasculartissues,additionalskinandnon-skincancers,andmelanomafamiliarity.Conclusions:WehighlightedthatVDRpolymorphismscanaffectVDRexpressioninexcisedmelanomacells.LowVDRexpressioninAATTcarriersisanewfindingthatmeritsfurtherstudy.VDRexpressionpossiblyposesimplicationsforvitaminDsupplementationagainstmelanoma.VDRexpressionandVDRgenotypemaybecomeprecisemedicinaltoolsformelanomainthefuture.

简介：Glia.2008Jul9.Four-and-a-half-LIMprotein2(FHL2)isamemberofFHLproteinfamily,whichplaysacrucialroleinregulatinggeneexpression,cellsurvival,andmigration.Althoughitsfunctioninoncogenesisappearstobetumortype-specific,itsrolesin

简介：ⅠTheStomachMeridianofFoot-Yangming1.TheMeridian[Course]Startingfromthesideofthenose,themeridianthendescendsfromthein-fraorbitalregiontoentertheuppergum.Itthencomesoutandgoesaroundthelipstoreachtheangleofthemandibleandtheforehead.Thede-scendingportionofthemeridianstartsfromthemandible,goesalongthethroat,entersthesupraclavicularfossa.Itthenfurtherpassesthrouththediaphragm,andfinallyconnectswithitspertainingorgan,thestomachanditsinteriorly-exteriorlyrelatedorgan,thespleen.

简介：客观:测量基于空间邻近的图象和相互的信息的类似原则调查一个4D-CT重建方法的可行性。方法:驾驶正弦曲线运动站台在房子里做了的一台马达被用来创造沿着CT睡椅的纵的轴的一个维的期刊运动。正弦曲线运动的振幅被设为一个振幅吗？

简介：无

简介：摘要目的分析振幅整合脑电图（aEEG）、脑电图（EEG）分型、全面无反应性量表（FOUR）评分在重型颅脑外伤性昏迷患者预后判断中的应用。方法选取2017年1月至2019年1月本院收治的重型颅脑外伤性昏迷的84例患者作为研究对象，采用aEEG监测、EEG分型以及FOUR评分对患者预后进行判断，分析其对预后判断的价值。结果aEEG、EEG分型、FOUR评分对预后判断结果与随访结果的Kappa值分别为0.628、0.468、0.569。aEEG、EEG分型、FOUR评分以及三者联合的灵敏度分别为78.79%、75.76%、66.67%、87.88%，特异度分别为84.31%、72.55%、78.43%、90.20%，阳性预测值分别为76.47%、64.10%、66.67%、85.29%，阴性预测值分别为86.00%、82.22%、78.43%、92.00%，准确度分别为82.14%、73.81%、73.81%、89.29%。联合检测的特异度、阳性预测值、准确度明显高于EEG分型（均P<0.05）；联合检测的灵敏度、阳性预测值、准确度明显高于FOUR评分（均P<0.05）。结论aEEG、EEG分型、FOUR评分对重型颅脑外伤性昏迷患者预后判断均有一定价值，其中aEEG的有效性略高于EEG分型、FOUR评分，并且三者联合预测的有效性高于单一指标预测，值得临床推广。