简介: [摘要 ] 目的 探讨乌司他丁在重症病毒性肺炎免疫调节治疗的临床疗效。 方法 回顾性分析 2017年 1月— 2019年 12月我院重症医学科收治的重症病毒性肺炎患者的临床资料,分析乌司他丁对患者免疫及预后的影响。结果 纳入 74例重症病毒性肺炎患者,死亡 19例( 25.7%) ;治疗组 36例,第 7天 CRP( 46.2±32.8) mmol/L、 HLA-DR( 60.02±12.08) %、 T-CD4+( 422±87) cell/L与第 0天的( 123±59.8) mmoL/L、( 41.22±15.90) %、( 220±54) cell/L间差异有统计学意义( P<0.05),且与对照组的( 34.1±11.8) mmol/L、( 42.06±14.08) %、( 326±69) cell/L间差异有统计学意义( t=1.781、 2.603、 2.527, P<0.05)。治疗组 28 d死亡 9例( 25.0%), VAP发生率为 21.77‰,低于对照组的 10例( 26.3%)( χ2=4.432, P=0.028)、 42.12%( χ2=0.017, P=0.897)。 结论 乌司他丁能改善重症病毒性肺炎患者的免疫功能,降低 VAP发生率,但无法改善预后。 [关键词 ] 重症病毒性肺炎 ;免疫干预 ;乌司他丁 [Abstract] Objective To investigate the clinical efficacy of ulinastatin in immunomodulatory therapy of severe viral pneumonia. Methods the clinical data of patients with severe viral pneumonia admitted to our hospital from January 2017 to December 2019 were retrospectively analyzed, and the effect of ulinastatin on immunity and prognosis of patients was analyzed. Results 74 patients with severe viral pneumonia were included, 19 (25.7%) died; There are 36 patients in the treatment group of 36 patients in the treatment group of 36 patients in the treatment group of 36 patients in the seventh day of CRP (46.2 ± 32.8) mmol / L, HLA-DR (60.02 ± 12.08), t-cd4 + (422 ± 87 ± 87) cell / L on the seventh day and (123 ± 59.8) mmol / L, (41.22 ± 15.90)%, (220 ± 54) cell / L (P < 0.05), and there are statistically significant differences between (34.1 ± 11.8) mmol / L, (42.06 ± 14.08)%, (326 ± 69) cell / L / L of the control group (t = 1.1.1.1.1.1.8) mmol / L, (42.06 ± 14.08 ± 14.08)%, (326 ± 69 781 2.603、 2.527, P<0.05)。 The incidence of VAP in the treatment group was 21.77 ‰, which was lower than that in the control group (26.3%) (χ 2 = 4.432, P = 0.028) and 42.12% (χ 2 = 0.017, P = 0.897). Conclusion Ulinastatin can improve the immune function of patients with severe viral pneumonia, reduce the incidence of VAP, but can not improve the prognosis.
简介:摘要目的 为改善ICU重症肺炎机械通气患者呼吸功能,特开展此次研究,将针对模块化护理的实施性做详细阐述。方法 随机选取我院ICU于2019年1月-2023年1月中收治的152例重症肺炎机械通气患者做为此次临床研究对象,均分两组后分别施以不同护理方案,后将相关数据予以整合分析后,做总结性报告。结果 通过模块化护理干预的实验组患者呼吸功能得到明显改善,且患者通气治疗时间、住院时间均有所缩短,护理满意度高达97.36%(74/76),组间数据统计P值均<0.05。结论 在ICU重症肺炎机械通气患者护理中开展模块化护理工作可对改善患者呼吸功能产生积极影响,且可减少通气、住院等治疗时间,进而提升患者对整体护理过程的满意率。