摘要
[摘要 ] 目的 对于脑卒中后继发癫痫患者临床治疗时选择拉莫三嗪联合丙戊酸钠用药的效果进行研究。 方法 选取我院在 2017年 6月～ 2019年 6月间收治的 90例脑卒中继发癫痫患者作为本研究对象，采用随机法分为观察组与对照组，每组 45例。对照组患者单纯采用丙戊酸钠治疗，而观察组患者在对照组药物基础上联合拉莫三嗪进行治疗，对比两组患者的治疗 1年后的治疗总有效率、治疗 1年后癫痫发作频率和癫痫持续发作时间以及不良反应发生率。 结果 治疗 1年后，观察组治疗的总有效率高于对照组，差异有统计学意义（ P<0.05） ;治疗 1年后观察组患者的的癫痫发作频率和癫痫持续发作时间均显著低于对照组，差异有统计学意义（ P<0.05） ;两组不良反应率比较，差异无统计学意义（ P>0.05）。 结论 相比传统采用丙戊酸钠治疗脑卒中后继发癫痫的效果，联合采用拉莫三嗪的临床疗效更加显著，不仅能提高治疗有效率，还能更好的控制癫痫发作频率和持续发作时间，改善患者的生活状态，值得在临床推广应用。
[关键词 ] 拉莫三嗪 ;丙戊酸钠 ;脑卒中 ;继发癫痫
[Abstract] Objective To study the effect of lamotrigine combined with sodium valproate in the treatment of epilepsy following stroke. Methods 90 patients with epilepsy following stroke who were admitted in our hospital from June 2017 to June 2019 were selected as the study subjects. They were randomly divided into the observation group and the control group， with 45 cases in each group. The control group was treated with sodium valproate alone， while the observation group was treated with lamotrigine on the basis of the control group. After one year after treatment， the total effective rate， the attack frequency and duration of epileptic seizures and the incidence of adverse reactions were compared between the two groups. Results After one year of treatment， the total effective rate of the observation group was higher than that of the control group， and the difference was statistically significant（ P<0.05） ; the attack frequency and duration of epilepsy in the observation group were significantly lower than those in the control group， and the difference was statistically significant（ P<0.05） ; there was no statistical difference in adverse reactions between the two groups （ P>0.05） . Conclusion Compared with the traditional use of sodium valproate alone in the treatment of epilepsy after stroke， the combined use of lamotrigine has a more significant clinical effect. It can not only improve the treatment effect， but also control the frequency and duration of epileptic seizures， improve the living quality of patients， which is worth promoting in the clinical treatment of such diseases.
[Key words] Lamotrigine; Sodium valproate; Stroke; Secondary epilepsy
临床脑卒中患者发病后，有的患者脑部会出现血块造成脑梗死，受到血块位置的影响，有的会压迫脑神经使脑神经组织出现异常放电，从而在脑卒中后继发癫痫，对脑组织结构造成严重破坏 [1-2]。脑卒中后继发癫痫给患者脑组织的功能恢复增加了难度，对患者的生活带来非常严重的影响。临床上多采用单一控制癫痫的药物进行治疗，如丙戊酸钠、卡马西平等，这些药物能降低脑神经细胞的兴奋度，可以控制癫痫发作，但是用药时间较长，对患者身体有较大的毒副作用 [3]。拉莫三嗪是一种新型的抗癫痫药物 [4]，本文旨在研究拉莫三嗪与丙戊酸钠联合用药在脑卒中后继发癫痫患者治療过程中的效果，现报道如下。
出版日期
2020年08月19日（中国期刊网平台首次上网日期，不代表论文的发表时间）
