CHEMOSENSITIVITY OF MGc80-3 HUMAN GASTRIC ADENOCARCINOMA CELLS AND ITS CLINICAL SIGNIFICANCE

(整期优先)网络出版时间:1990-01-11
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Inthepresentstudy,thechemosensitivityofMGc80-3humangastricadenocarcinomacellswasdeterminedbymeansofcolony-formingassayandtheinvitroactivitiesof10anticancerdrugswereexaminedonthebasisoftheclinicallyachievablepeakplasmadrugconcentration.TheresultsshowedthatMGc80-3cellsweremostsensitivetomitomyc’nC,adriamycinand5-fluorouracil,beingconsistentwiththeresponsenotedinclinicalgastriccancer.Thiscelllinemayretainitsoriginaldrugsensitivityandmaybeusefulinscreeningfornewcompoundswithactivityagainstthisdisease.