Inthepresentstudy,thechemosensitivityofMGc80-3humangastricadenocarcinomacellswasdeterminedbymeansofcolony-formingassayandtheinvitroactivitiesof10anticancerdrugswereexaminedonthebasisoftheclinicallyachievablepeakplasmadrugconcentration.TheresultsshowedthatMGc80-3cellsweremostsensitivetomitomyc’nC,adriamycinand5-fluorouracil,beingconsistentwiththeresponsenotedinclinicalgastriccancer.Thiscelllinemayretainitsoriginaldrugsensitivityandmaybeusefulinscreeningfornewcompoundswithactivityagainstthisdisease.