OBJECTIVE:ToevaluatetheassociationofX-raycross-complementinggroup1(XRCC1)Arg399Gln,Arg194TrpandArg280Hispolymorphismswiththeriskofglioma.DATASOURCES:AsystematicliteraturesearchofpaperspublishedfromJanuary2000toAugust2012inPubMed,Embase,ChinaNationalKnowledgeInfrastructuredatabase,andWanfangdatabasewasperformed.Thekeywordsusedwere"glioma","polymorphism",and"XRCC1orX-rayrepaircross-complementinggroup1".Referencescitedintheretrievedarticleswerescreenedmanuallytoidentifyadditionaleligiblestudies.STUDYSELECTION:Studieswereidentifiedaccordingtothefollowinginclusioncriteria:case-controldesignwasbasedonunrelatedinpiduals;andgenotypefrequencywasavailabletoestimateanoddsratio(OR)and95%confidenceinterval(CI).Meta-analysiswasperformedfortheselectedstudiesafterstrictscreening.Dominantandrecessivegeneticmodelswereusedandtherelationshipbetweenhomozygousmutantgenotypefrequenciesandmutantgenefrequencyandgliomaincidencewasinvestigated.WechosethefixedorrandomeffectmodelaccordingtotheheterogeneitytocalculateORand95%CI,andsensitivityanalyseswereconducted.PublicationbiaswasexaminedusingtheinvertedfunnelplotandtheEgger’stestusingStata12.0software.MAINOUTCOMEMEASURES:AssociationofXRCC1Arg399Gln,Arg194Trp,andArg280Hispolymorphismswiththeriskofglioma,andsubgroupanalyseswereperformedaccordingtodifferentethnicitiesofthesubjects.RESULTS:Twelvearticleswereincludedinthemeta-analysis.ElevenofthearticleswereconcernedwiththeArg399Glnpolymorphismandgliomaonsetrisk.Significantlyincreasedgliomariskswerefoundonlyinthedominantmodel(Gln/Gln+Gln/ArgversusArg/Arg:OR=1.26,95%CI=1.03-1.54,P=0.02).Inthesubgroupanalysisbyethnicity,significantlyincreasedriskwasfoundinAsiansubjectsintherecessive(OR=1.46,95%CI=1.04-2.45,P=0.03)anddominantmodels(OR=1.40,95%CI=1.10-1.78,P=0.007),andhomozygotecontrast(OR=1.69,95%CI=1.17-2.45,P=0.005),bu
