Acousticfatiguelifeevaluationisessentialforthermalprotectionstructuresduetotheseverethermo-acousticloadinservice.AstudyontemperaturedependenceofacousticfatiguelifeforaC/SiCpanelispresentedinthispaper.EffectsoftemperatureonboththestructuralresponsesandtheS–Ncurvesareinvestigated.TheDirlikmethodisadoptedtopredictthefatiguelifeofaC/SiCpanelatthreedifferenttemperaturesrespectively.Significantdifferencesareobservedfromtheresultsofnumericalsimulationsbetweenthefatiguelivesofthepanelinthethreecases.Thetemperature-dependenceofacousticfatiguelifeofaC/SiCpanelisverified,andfatiguetestofthematerialneedstobemoreattentivelyperformed.