Recentstudieshaverevealedthatthepropertyofdrugismainlyassociatedwiththebody'ssubstanceandenergyme-tabolism.ThepresentstudyaimedtoevaluatethedrugpropertyofPoria,calledFuling(FL)intraditionalChinesemedicine(TCM),intermsofitseffectsonthesubstanceandenergymetabolisminratmodelsofcold-deficiencyandheat-deficiencysyndromes,comparedwithAconitiLateralisRadixPraeparaia,calledFuzi(FZ)inTCM,withhotproperty,andAnemarrhenaeRhizoma,calledZhimu(ZM)inTCM,withcoldproperty,asreferencedrugs,respectively.Theappearancescore,toeandrectaltemperaturesoftheanimalstreatedwereassessedatdifferenttimepoints.Severalindicesinvivocorrelatedwithsubstanceandenergymetabolism(glucokinas,phosphoglyceratekinase,cytochromecreductase,cytochromecoxydase,andNa^+-K^+-ATPase),endocrinesystem(triiodothyronine,thyroxine,and17-hydroxycorticosteroid),nervoussystem(acetylcholinesterase),andcyclicnucleotidesystemweredetermined.Thechangesinappearancescoreandindicesinvivosuggestedthesuccessfulestablishmentofcold-deficiencyandheat-deficiencysyndromemodels.FZreversedthedecreasedlevelsofindices(substanceandenergymetabolismandendocrinesystem)andalleviatedthesyndromeofcold-deficiencymodel,andZMshowedobviouslytherapeuticeffectonheat-deficiencysyndrome(appearancescore,substanceandenergymetabolism,andendocrinesystem).FLcouldalleviatecold-deficiencysyndromeandraisethedecreasedlevelsofglucokinas,phosphoglyceratekinase,cytochromecreductaseandtriiodothyronineincold-deficiencymodel,buthadnosignificanteffectonheat-deficiencysyndrome.DrugpropertyofFLwasinferredastrendingto"flatandwarm",whichstillneedfurtherstudy.Itwasadvisabletoadoptbothcold-deficiencyandheat-deficiencymodelstostudythedrugswith"flat"property.
