Thelymphaticsystemhasanimportantdefensiveroleinthehumanbody.Themetastasisofmosttumorsinitiallyspreadsthroughthesurroundinglymphatictissueandeventuallyformslymphaticmetastatictumors;thetumorcellsmayeventransfertootherorganstoformothertypesoftumors.Clinically,lymphaticmetastatictumorsdeveloprapidly.Giventhelimitationsofsurgicalresectionandtheloweffectivenessofradiotherapyandchemotherapy,thetreatmentoflymphaticmetastatictumorsremainsagreatchallenge.Lymphnodemetastasismayleadtothefurtherspreadoftumorsandmaybepredictiveoftheendpointevent.Underthesecircumstances,novelandeffectivelymphatictargeteddrugdeliverysystemshavebeenexploredtoimprovethespecificityofanticancerdrugstotumorcellsinlymphnodes.Inthisreview,wesummarizetheprinciplesoflymphatictargeteddrugdeliveryanddiscussrecentadvancesinthedevelopmentoflymphatictargetedcarriers.
