Current practices and guidelines for clinical next-generation sequencing oncology testing

(整期优先)网络出版时间:2016-01-11
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Next-generationsequencing(NGS)hasbeenrapidlyintegratedintomolecularpathology,dramaticallyincreasingthebreadthgenomicofinformationavailabletooncologistsandtheirpatients.Thisreviewwillexplorethewaysinwhichthisnewtechnologyiscurrentlyappliedtobolstercareforpatientswithsolidtumorsandhematologicalmalignancies,focusingonpracticesandguidelinesforassessingthetechnicalvalidityandclinicalutilityofDNAvariantsidentifiedduringclinicalNGSoncologytesting.