AIM:Topredictthevisualoutcomeinpatientsundergoingmacularholesurgerybytwonovelthree-dimensionalmorphologicalparametersonopticalcoherencetomography(OCT):arearatiofactor(ARF)andvolumeratiofactor(VRF).METHODS:Aclinicalcaseserieswasconducted,including54eyesof54patientswithanidiopathicmacularhole(IMH).EachpatienthadanOCTexaminationbeforeandaftersurgery.Morphologicalparametersofthemacularhole,suchasminimumdiameter,basediameter,andheightweremeasured.Then,themacularholeindex(MHI),tractionalholeindex(THI),andholeformfactor(HFF)werecalculated.Meanwhile,novelpostoperativemacularhole(MH)factors,ARFandVRFwerecalculatedbythree-dimensionalmorphology.Bivariatecorrelationswereperformedtoacquireasymptoticsignificancevaluesbetweenthesteadybestcorrectedvisualacuity(BCVA)aftersurgeryand2D/3DargumentsofMHbythePearsonmethodwithtwo-tailedtest.Allsignificantfactorswereanalyzedbythereceiveroperatingcharacteristic(ROC)curveanalysisofSPSSsoftwarewhichwereresponsibleforvisionrecovery.ROCcurvesanalyseswereperformedtofurtherdiscussthedifferentparametersonthepredictionofvisualoutcome.RESULTS:Themeanandstandarddeviationvaluesofpatients'age,symptomsduration,andfollow-uptimewere64.8±8.9y(range:28-81),18.6±11.5d(range:2-60),and11.4±0.4mo(range:6-24),respectively.Steady-postBCVAanalyzedwithbivariatecorrelationswasfoundtobesignificantlycorrelatedwithbasediameter(r=0.521,P<0.001),minimumdiameter(r=0.514,P<0.001),MHI(r=-0.531,P<0.001),THI(r=-0.386,P=0.004),HFF(r=-0.508,P<0.001),andARF(r=-0.532,P<0.001).Othercharacteristicparameterssuchasage,durationofsurgery,height,diameterholeindex,andVRFwerenotstatisticallysignificantwithsteady-post-BCVA.Accordingtoareaunderthecurve(AUC)values,valuesofARF,MHI,HFF,minimumdiameter,THI,andbasediameterare0.806,0.772,0.750,0.705,0.690,and0.686,respectively.However,Steady-post-BCVAanalysiswithbivar
