Artesunaeisaderivativeofqinghaosu,withasesquiterpenestructure.Thespecificactionandtheclinicalusesofartesunateareonthepreliminarystage,ontheonehand,artesunatehasspecificactionofbothantiinflammationandantivirus,andalsohasprotectiveeffectonthepulmonaryalveolarmacrophages,whuichmaybeadvantageoustothetreatmentoftheairwaynon-specificinflammationofasthma,.Ontheotherhand,qinghaousuhastheactivitiestorelaxvascularsmoothmuscleandtocausehypotension.Theexpectorantaction,theantitussiveactionandtheantuiasthmaticactionofqinghaosuwerepreported.Artesunatemayalsohaveantiasthmaticactivity,becausetheantimalarialpotencyofartesunateisstrongerthanthatofqinghaosu,andArtesunatecanblockCa^2+influxbyinhibitingcalcium-dependentchloridecurrent.Themainaimsofthispaperaretoinvestigatethesite,themode,andthemechanismofartesunateactiononisolatedtrachealsmoothmusclefromtheguinea-pig.
