Fractional Flow Reserve Measurement by Coronary Computed Tomography Angiography:A Review with Future Directions

(整期优先)网络出版时间:2016-09-12
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Invasivefractionalflowreserve(FFR)measurementiscurrentlythegoldstandardforcoronaryintervention.FFRmeasurementbycoronarycomputedtomographyangiography(FFRCT)isanovelandpromisingimagingtechnologythatpermitsnoninvasiveassessmentofphysiologicallysignificantcoronarylesions.FFRCTiscapableofcombiningtheanatomicinformationprovidedbycoronarycomputedtomographyangiographywithcomputationalfluiddynamicstocomputeFFR.Todate,severalstudieshavereportedthediagnosticperformanceofFFRCTcomparedwithinvasiveFFRmeasurementasthereferencestandard.FurtherstudiesarenowbeingimplementedtodeterminetheclinicalfeasibilityandeconomicimplicationsofFFRCTtechniques.ThisarticleprovidesanoverviewanddiscussestheavailableevidenceaswellaspotentialfuturedirectionsofFFRCT.