Hepatocellularcarcinoma(HCC),thepredominantformofadultlivermalignancies,isaglobalhealthconcern.Itsdismalprognosishaspromptedrecentsignificantadvancesintheunderstandingofitsetiologyandpathogenesis.Thederegulationofepigeneticmechanisms,whichmaintainheritablegeneexpressionchangesandchromatinorganization,isimplicatedinthedevelopmentofmultiplecancers,includingHCC.ThisreviewsummarizesthecurrentknowledgeofepigeneticmechanismsinthepathogenesisofHCC,withanemphasisonHCCmediatedbychronichepatitisBvirusinfection.Thisreviewalsodiscussestheencouragingoutcomesandlessonslearntfromepigenetictherapiesforhematologicalandothersolidcancers,andhighlightsthefuturepotentialofsimilartherapiesinthetreatmentofHCC.
