Single-Ion Microbeam for Applications in Radiobiology: State of the Art

(整期优先)网络出版时间:2005-02-12
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Single-IonMicrobeam(SIM)isuniquelycapableofpreciselydeliveringapredefinednumberofchargedparticles(precisedosesofradiation)toinpidualcellsorsub-cellulartargetsinsitu.Sincetheearly1990's,therehasbeenanever-increasinginterestindevelopingandapplyingtheSIMtechniquetoproblemsinradiobiologyforstudiesofcellandtissuedamagedbyionizingradiations.PotentialapplicationsforSIMinradiobiologycontinuestogrowandhavebeenpersified.Therearecurrentlymorethan14SIMfacilitiesworldwide,andtheyhavebeeninaconstantstateofevolution.ThispaperreviewsthecurrentstateofSIMresearchworldwideandtherelatedpivotaltechnologicaldevelopmentsinthefieldsofbothbiophysicsandradiobiology.RepresentativeapplicationsandtheperspectiveofSIMarealsointroducedanddiscussed.