Towards Developing a Malaria Vaccine Based on CD4 T Cell Mediated Immunity in Blood Stage of Malaria Infection

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• Mobilizing forces - CD4^＋ helper T cells script adaptive immunity
• Innate immunity against malaria parasites in Anopheles gambiae
• Novel function of perforin in negatively regulating CD4^＋ T cell activation by affecting calcium signaling
• Malaria
• Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway

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