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简介：Thispaperreviewsourworkonthefundamentalprinciplesofhighgravitycontrolledprecipitation(HGCP)technology,anditsapplicationsintheproductionofdrugnanoparticles,whichwascarriedoutinarotatingpackedbed(RPB).Severalkindsofdrugnanoparticleswithnarrowparticlesizedistributions(PSDs)weresuccessfullypreparedviaHGCP,includingthe300-nmCefuroximeAxetil(CFA)particles,200–400-nmcephradineparticles,500-nmsalbutamolsulfate(SS)particles(100nminwidth),and850-nmbeclomethasonedipropionate(BDP)particles,etc.Comparedtodrugsavailableinthecurrentmarket,allthedrugnanoparticlesproducedbyHGCPexhibitedadvantagesinbothformulationanddrugdelivery,thusimprovingthebioavailabilityofdrugs.HGCPisessentiallyaplatformtechnologyforthepreparationofpoorlywater-solubledrugnanoparticlesfororalandinjectiondelivery,andofinhalabledrugsforpulmonarydelivery.Consequently,HGCPofferspotentialapplicationsinthepharmaceuticalindustryduetoitscost-effectiveness,efficientprocessingandtheeaseofscaling-up.

简介：RigidFiniteElementMethod(RFEM)wasproposedtosimulatethemechanicalbehaviorofdiscontinuousstructuressuchasrockandsoilstructures.Theauthors’workonthetheoryandapplicationsofRFEMissummarizedinthispaper.BasedonthetheoryofRFEM,theElasticBody-SeamsModel(EBSM)isproposedtotakethedeformationanddamageofrockmassesintoaccount.

简介：Inthispaperthemethodofdamagemeasurementofmetalstructureatthecreepisproposed.Incontrasttoothermethods,itallowsthemeasurementofthisdamagetobecarriedoutintheprocessofcreeptestwithoutunloadingandcoolingofspecimens.Experimentaldamagecurvesduringcreepareobtainedasaresultoftestdataprocessingbythesuggestedmethod.Theanalysisofthesecurvesleadstoaconclusionthatthematerialdamageatreptureismonotonicallydecreasingfunctionoftheappliedstress.Thisconclusionisanexperimentalverificationofthetheoreticalresult,obtainedearlier.

简介：Themulti-scalestructuresofcomplexflowsinchemicalengineeringhavebeengreatchallengestothedesignandscalingofsuchsystems,andmulti-scalemodelingisthenaturalwayinresponse.Particlemethods(PMs)areidealconstituentsandpowerfultoolsofmulti-scalemodels,owingtotheirphysicalfidelityandcomputationalsimplicity.Especially,pseudo-particlemodeling(PPM,Ge&Li,1996;Ge&Li,2003)ismostsuitableformolecularscaleflowpredictionandexplorationoftheoriginofmulti-scalestructures;macro-scalePPM(MaPPM,Ge&Li,2001)andsimilarmodelsareadvantageousformeso-scalesimulationsofflowswithcomplexanddynamicdiscontinuity,whilethelatticeBoltzmannmodelismorecompetentforhomogeneousmediaincomplexgeometries;andmeso-scalemethodssuchasdissipativeparticledynamicsareuniquetoolsforcomplexfluidsofuncertainpropertiesorflowswithstrongthermalfluctuations.Allthesemethodsarefavorableforseamlessinterconnectionofmodelsfordifferentscales.However,asPMsarenotoriginallydesignedaseithertoolsforcomplexityorconstituentsofmulti-scalemodels,furtherimprovementsareexpected.PPMisproposedformicroscopicsimulationofparticle-fluidsystemsasacombinationofmoleculardynamics(MD)anddirectsimulationMonte-Carlo(DSMC).ThecollisiondynamicsinPPMisidenticaltothatofhard-sphereMD,sothatmass,momentumandenergyareconservedtomachineaccuracy.However,thecollisiondetectionprocedure,whichismosttime-consuminganddifficulttobeparallelizedforhard-sphereMD,hasbeengreatlysimplifiedtoaprocedureidenticaltothatofsoft-sphereMD.Actually,thephysicalmodelbehindsuchatreatmentisessentiallydifferentfromMDandismoresimilartoDSMC,butanintrinsicdifferenceisthatinDSMCthecollisionsfollowdesignedstatisticalrulesthatarereflectionoftherealphysicalprocessesonlyinverylimitedcasessuchasdilutegas.PPMisidealforexploringthemechanismofcomplexflowsa

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简介：Dispersionofmulti-walledcarbonnanotubesinpoly(p-phenylene)compositeexposedtotoluenewasexperimentallyinvestigated.3mgofmulti-walledcarbonnanotubeswithnominalsizeof20nmwascompoundedwith30mgofpoly(p-phenylene)withthepresenceofterpineolasbindinginitiator.Toinvestigateanoptimalconditionforhomogenizingallconstituents,ultrasonicationwithanoutputpowerof750Wwasemployedwithcompoundingtimeof3,10,20and30min.WithFTIRanalyses,itcouldbeconfirmedthathomogeneouscompositeofmulti-walledcarbonnanotubesandpoly(p-phenylene)couldbeprepared.SEManalyseswerealsoconductedtoexaminethedispersionofmulti-walledcarbonnanotubesinthepolymermatrix.Thenintrinsicelectricalresistanceofthecompositesafterbeingexposedtotoluenewasalsoinvestigated.Itwasfoundthatthecompositefilmpreparedwithultrasonicationfor20mincouldprovidesufficientlysensitiveresponsewithrespecttovariedconcentrationoftoluene.

简介：Shape-inducedphasetransitionofvortexdomainstructures(VDSs)inBaTiO_3(BT)nanodotsunderopencircuitboundaryconditionhavebeeninvestigatedusinganeffectiveHamiltonianmethod.OurcalculationindicatesthetetragonalVDSmissingincubicBTnanodotscanbeinducedbyvaryingtheshapeofananodotfromcubetoplatelet.Interestingly,anovelVDSisfoundinBTnanoplateletsinoursimulations.Furtherinvestigationshowsthatitisaresultofcompromisebetweenthegroundstateandthesymmetryoftheshapeofthenanodot.Furthermore,basedonthenovelVDS,routesofcontrollingVDSsgovernedbyhomogeneouselectricfieldanduniformstressarediscussed.Inparticular,ourresultsshowthepossibilityofdesigningmulti-statesdevicesbasedonasingleVDS.