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简介：Breastmetastasisfromextra-mammarymalignancyisrare.Anincidenceof0.4%to1.3%hasbeenreportedinliterature.Theprimarymalignanciesthatmostcommonlymetastasizetothebreastareleukemia,lymphoma,andmalignantmelanoma.Inthisreport,twocasesofpulmonarymetastasistothebreastwerepresented.A40-year-oldfemalemanifestedarightbreastmassof2-monthduration.Afterphysicalexaminationwasperformed,apoorlydefinedmasswasnotedintheupperouterquadrantoftherightbreast.Another49-year-oldfemalemanifestedrightbreastmassof5-dayduration.Apoorlydefinedmasswasnotedinthelowerinnerquadrantoftherightbreast.Mammographyresultsalsorevealedbreastcancer.Thepatientsunderwentlocalexcision.Afterhistologicalandimmunohistochemicalanalyseswereconducted,aprimarylungcarcinomathatmetastasizedtothebreastwasdiagnosed.Anaccuratedifferentiationofmetastasistothebreastfromprimarybreastcancerisveryimportantbecausethetreatmentandprognosisofthetwodiffersignificantly.

简介：Objective:Toinvestigatetheeffectoftwoantisenseoligonucleotidesoncellsurviving,bcl-2expressionandapoptosisofleukemiacells.Methods:Theexperimentalassayswereperformedwithcellculture,immunochemistryandflowcytometry.Results:Thetwoantisenseoligodeoxynucleotides,combinedwithVp16orAra-corDNR,wereabletodeclinethesurvivalrateofmyeleukemiccells,downregulatebcl-2geneexpressionandinduceapoptosisofleukemiccellssignificantly,ascomparedwithVp16orAra-corDNRalone.Conclusion:Itispossibleforthetwonewbcl-2antisensestobedevelopedintoclinicaltrialsforleukemiaandtumorwithbcl-2geneoverexpression.

简介：Intradiploicepidermoidcysts,fairlyuncommonlesionsinneurosurgicalpractice,are,asarule,benignandslow-growing.Somemayattaingreatsize.Correctradiologicalassessmentandcompleteremovalofthetumoranditscapsuleareessentialforadequatesurgicaltreatmentandgoodlong-termprognosis.Wereporttwocasesofintradiploicepidermoidcystsoftheskull,withgiantandCT-hyperdenselesionswithextraandintracranialextension,andanalyzetheclinicopathologicalandimagingfeaturesandtreatmentoftheselesionsinthelightofthemostimportantpublisheddata.

简介：TherearesomeIndicationsthttherpesaimplexvirus(HSV)maybemutagenic.SpecificchromosomalchangeshavealsobeendemonstratedInculturedcellsinfectedwithHSV.TofurtherInvestigatethemutagenicactivityofHSVtype2(HSV-2)weusedmouseskinasamodelsystemforcardnogenetls.Inoculationofthebackskinof4-week-oldSencarmkewithlivevirustwiceperweekforoneweekorwithInactivatedvirustwiceperweekfortwoweekswasusedtoInitiatethemouseakin.AfterInitiationwithHSV-2,12-O-tetradecanoylphorbol-13-acetale(TPA)wasappliedtwiceweeklyfor50weeksasapromoter.Duringaperiodof52weeks,noskincarcinomawasfoundIntheexperimentalgroups,whereas55%ofcontrolmicetreatedwith9,10-dlmethy1-1,2-benzanthracene(DMBA)andthenwithTPA-developedskincarcinoma.TheresultsdemonstratethatHSV-2couldnotsubstituteforDMBAinthisanimalmodeloftwo-stageskincarcinogenesis.

简介：Themanagementofcastrate-resistantprostatecancerprogressingaftermaximumandrogenblockade(MAB)hasevolvedinthelastdecadewiththedevelopmentofseveralnoveltherapeuticoptions.However,theinitialtherapeuticstrategyinthesepatientsusuallyinvolveswithdrawalofanti-androgenthatcanbeassociatedwithbiochemicalresponseinapproximately20%ofpatients.Notably,wehaveobservedevidenceofsustainedbiochemicalresponseintwopatientsfollowingsecondandthird-lineMABusingrechallengescheduleofpreviouslyadministeredanti-androgenafterlatentinterval.ThepossibilityofresponsefollowingsequentialMABusingthesameanti-androgenagenthasnotyetbeenreported.

简介：Molecularsubtypingofbreastcancermayprovideadditionalprognosticinformationregardingpatientoutcome.Theepidermalgrowthfactorreceptor(HER2)overexpressingbreastcancersaredesignatedasHER2-postive(HER2+)breastcancerandcarryaparticularlyunfavorableprognosis.WepresenttwocasesofHER2-postivemetastaticbreastcancer(MBC)whoarefoundtobeachallengetotreat,especiallyduetotheoccurrenceofbrainmetastasis.Trastuzumab-basedtherapyimprovesclinicaloutcomes,evenifthepatienthasundergonemulti-linetreatment.ThesecasereportsalsoemphasizetheimportanceofretestingHER2statusbecauseitcanbediscordanceinreceptorstatusbetweenprimaryandrecurrentbreastcancer.

简介：Bevacizumabisoneoftheraredrugsthatcouldimprovehigh-gradegliomaoutcomeafterfailureofchemoradiotherapy.However,todate,thereisnobiomarkerpredictiveforefficacyofbevacizumabtherapyintermsofsurvivalimprovementforpatientswithhigh-

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简介：先于尖锐myeloid白血病(AML)的Myeloid肉瘤(MS)是稀罕的，作为尖锐针的绳索压缩介绍是它甚至稀罕。这里，我们报导myeloid肉瘤病人，其结果不同的二个新案例。有针的MS前面的AML的27个病人迄今为止被报导了，包括在这篇文章介绍的二个案例。外科的解压缩在27个病人中的25个被执行，并且这些中的23个收到了另外的anti-AML治疗。就我们在文学的病人和出版案例而言，我们建议immunohistochemical学习在到达MS，和那个紧急情况手术的正确诊断到针的MS是的将切除起一个必要作用做神经功能恢复的可得到的治疗，并且疾病必须与类似于过去常在肿瘤的切除术或照耀以后尽快对待AML那的集中的化疗被治疗。

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