简介:Canprogesteronebeabetteralternativetodexamethasoneforuseinroutinebrainsurgery?Surgicalbraininjury(SBI)isaformofbraintraumacausedbyvariousformsofneurosurgicalinterventionsincludingbraintumorexcision,evacuationofintracerebralhemorrhageandbrainlobectomy(e.g.,inepilepsysurgery).CerebraledemaandbrainswellingtypicallyoccurssoonafterSBIandcommonlypeaksonpost-operativedays3to7.SBImaycause
简介:BACKGROUND:ToevaluatethequalityoftheliteratureaddressingtraditionalChinesemedicinefortreatingParkinson'sdisease.DATASOURCE:Acomputer-basedonlinesearchofChinesepublicationsfromJanuary2001toJuly2008wasconductedinChineseBiologyMedicalDiscDatabaseandChinaNationalKnowledgeInfrastructure.SearchkeywordswereParkinson'sdisease,integratedtraditionalChineseandWesternmedicine,traditionalChinesemedicinetherapy,andChineseherbtherapy.DATASELECTION:Articlesdescribingrandomized,controlledtrialsandquasi-randomized,controlledtrialswereincluded.Literaturequalitywasassessedusingthecriteria-SystematicevaluationofclinicalliteraturerelatedtotreatmentofParkinson'sdiseasewithtraditionalChinesemedicine.Thisincludedmethodology,interventionsinthetreatment/controlgroup,evaluationcriterionofoutcomes,andfrequency.MAINOUTCOMEMEASURES:Evaluationcriterionofoutcomes(variousscoremethodsandevaluationscales),methodologicalquality,andfrequencydistributionwereallmeasured.RESULTS:Atotalof33articleswithrandomized,controlledtrialswereincluded.Ofthese,sixdescribedarandommethod,andtheremainingdidnotdescriberandomallocationmethodsorrandomsequencegenerationmethods.Noneofthestudiesestimatedsamplesize.Casedescriptionsofwithdrawalandlosstofollow-upwereunclear.BoththeUnifiedParkinson'sDiseaseRatingScaleandWebsterscalewereusedintheeligiblestudiesasevaluationcriteria.CONCLUSION:Therearenohigh-qualitystudiesthataddresstraditionalChinesemedicinetherapyandintegratedtraditionalChineseandWesternmedicinefortreatingParkinson'sdiseaseinChina.EligiblestudieswerenotperformedinaccordancewithConsolidatedStandardsofReportingTrialsstatementorStandardsforReportingInterventionsinControlledTrialsofAcupuncturecriteria,andtheliteraturequalitywaslow.ThepresentlyusedcriteriaforevaluatingtherapeuticeffectsdonotcompletelyassessoutcomesoftraditionalCh
简介:Psychologicaldepressionisdrawingaccumulatingattentionnowadays,duetotheskyrocketingincidenceworldwideandtheenormousburdensitincurs.Physicalexercisehasbeenlongrecognizedforitstherapeuticeffectsondepressivedisorders,althoughknowledgeoftheunderlyingmechanismsremainslimited.Suppressedhippocampalneurogenesisinadultbrainshasbeenregarded,atleastpartly,contributivetodepression,whereasphysicalexercisethatrestoresneurogenesisaccordinglyexertstheanti-depressiveaction.Severalrecentpublicationshavesuggestedthepotentialroleofadiponectin,aproteinhormonesecretedbyperipheralmatureadipocytes,inmediatingphysicalexercise-triggeredenhancementofhippocampalneurogenesisandalleviationofdepression.Here,webrieflyreviewthesenovelfindingsanddiscussthepossibilityofcounteractingdepressionbymodulatingadiponectinsignalinginthehippocampuswithinterventionsincludingphysicalexerciseandadministrationofpharmacologicalagents.更多还原
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