简介：AIM:ToconductaMeta-analysisforinvestigatingthevariationsinintraocularpressure(IOP)andcentralcornealthickness(CCT)duringnormalpregnancy.METHODS:WesearchedforclinicaltrialspublisheduptoNovember2015withoutlanguageorregionrestrictionsinPubMed,EMBASE,WebofScience,theCochraneCentralRegisterofControlledTrials,Ovid,EBSCO,Elsevier,theChineseBiomedicineDatabase,WanFang,CNKI,CQVIPandGoogleScholar.Studiesoftheocularchangesobservedinpregnantwomenwereselected.ThemainoutcomeswereassessedbychangesinIOPandCCT.RESULTS:Fifteenstudieswereincluded.Insubgroupanalyses,IOPwassignificantlydecreasedduringthesecondMD=-1.53,95%CI(-2.19,-0.87);P<0.00001,andthirdMD=-2.91,95%CI(-3.74,-2.08);P<0.00001trimestersofpregnancy.CCTwasincreasedduringthesecondMD=10.12,95%CI(2.01,18.22);P=0.01,trimesterofpregnancy;moreover,duringthethirdtrimesterofpregnancy,theCCTdisplayedanincreasingtrend,butthedifferencewasnotsignificantMD=5.98,95%CI(-1.11,13.07);P=0.1.CONCLUSION:AdecreaseinIOPisaccompaniedbyanincreaseinCCTinthesecondandthirdtrimestersofanormalpregnancyinwomen.