简介:【摘要】目的:分析后路和前路手术内固定融合术用于脊柱骨折的价值。方法:2021年5月-2022年5月本科接诊脊柱骨折病人70名,随机均分2组。试验组采取后路手术内固定融合术,对照组采取前路手术内固定融合术。对比ACTH水平等指标。结果:关于ACTH水平,术后:试验组数据(51.43±6.04)ng/L,和对照组数据(63.47±7.38)ng/L相比更低(P<0.05)。关于Cobb’s角,术后:试验组数据(6.79±1.34)°,和对照组数据(11.83±1.93)°相比更低(P<0.05)。结论:脊柱骨折用后路手术内固定融合术,ACTH水平降低更加明显,Cobb’s角改善更为迅速。
简介:Aim:Tostudypercutaneousabsorptionandmetabolismofketoprofenisopropylester(KPE)viaexcisednudemouse'sandmonkey'sskin.Methods:Excisedskinwaspreparedbysurgicalexcisionandenzymedigestion.Sideby-sidediffusioncellswereusedforinvitropermeationstudies.TheconcentrationsofKPEanditsmetaboliteinsampleswereassayedbyHPLC.Results:AllKPEpenetrationthroughwholethicknessskinandstrippedskinwasmetabolizedtoketoprofen(KP).theconcentrationofwhichinthereciiversolutionincreasedlinearlywithtime.Astothenudemouseskin.thesteady-statefluxofKPthroughwholethicknessskinwas2.5timesthatofKPEthroughthewhloethicknessskin,buttheKPandKPEremaininginthewholethicknessskinafterthefinishingofKPEpenetrationwas22.2timesincomperedwiththeKPremaininginthewholethicknessskinafterthefinshingofKPpenetration.TherateofformationofthesteadystateKPfromKPEthroughtdermiswassignificantlylowerthanthatofKPEthroughthewholethicknessskin.Inhemonkeyskin,therateofformationofthesteady-stateKPfromKPEthroughthewholethicknessskinwas0.7timesthatfromKPEthroughstrippedskin.TheKPandKPEremaininginthewholethicknessskinafterthefinishingofKPEpenetrationwas2.0timethatinthestrippedskinafterthefinishingofKPEpenetration.Therateoffornationofthesteady-stateKPfromKPEthroughdermiswaslowerthanthatfromKPEthroughthewholethicknessskinandthestrippedskin.theKPremainingindermisafterthefinsihingofKPEpenetrationwasalsosignificantlylowerthantheKPremaininginthewholethicknessskinandthestrippedskinafterthefinishingofKPEpenetration.Conclusion:KPestersareofbenefittoimporovethelocalactionofKP.andskinesterasemetabolismmainlydevelopsintheepidermis.
简介:目的探讨乙型肝炎病毒pre—S1Ag、pre—S2Ag、HBV—DNA、HBV—M的相关性及其临床意义。方法HBV—DNA采用荧光定量PCR法;HBV—M及pre—S1Ag、pre—S2Ag采用ELISA法,检测96例HBV—DNA阳性感染者血清中pre-S1Ag、pre—S2Ag、HBV—M,同时以30例HBV—M全阴性的健康体检者血清作为对照,并对结果进行统计学分析。结果96例HBV—DNA阳性患者中HBsAg、HBeAg、HBcAb阳性检出率为64.6%;HBsAg、HBeAb、HBcAb阳性检出率为20.8%;HBsAg、HBcAb阳性栓出率为14.6%;pre—S1Ag在96例HBV—DNA阳性标本中检出率为70.8%;pre—S2Ag检出率为79.2%;均明显高于HBeAg的阳性率64.6%,30例对照中未检测出pre—S1Ag、pre—S2Ag及HBV—DNA。结论HBeAg、HBV—DNA、pre—S1Ag、pre—S2Ag之间具有一定的关联性。pre—S1Ag和pre—S2Ag均较HBeAg敏感。pre—S1Ag与pre—S2Ag的栓出率差异无显著性,ELISA检测HBV—M、pre—S2Ag及pre—S1Ag只是表型指标,只能提供HBV感染的间接证据。而HBV—DNA的检测是HBV感染与否的直接证据。HBV—M、pre—S1Ag、pre—S2Ag、HBV—DNA的检测各自有其独特的临床意义。应用pre—S1Ag、pre—S2Ag、HBV—DNA及HBV—M进行联合检测,对HBV感染的早期诊断,了解HBV复制、转归及监测疗效和预后有重要的意义。
简介:Pyrimidinederivativeshavebeenreportedasneuroprotectiveagentsusefulforthetreatmentofvariousneurodegenerativedisorders.Inthepresentstudy,severalpyrimidineanalogueshavebeenevaluatedasneuroprotectiveagentsinMorriswatermazemodel.Itwasobservedthatpyrimidinederivatives8–17considerablyimprovelearning,memory,andmovementdeficitsinanimalmodels.Biochemicalestimationsofbrainserumoftreatedanimalsrevealedsuppressionofoxidativeandnitrosativestress,acetylcholinesteraseactivity,andotherparameterswhichleadstoneurodegenerationofbrain.Ofallthepyrimidinederivatives,thiomorpholinederivative8andpiperazineethanolderivative17werefoundtobethemostactiveneuroprotectiveagentsandproducedeffectscomparabletostandarddrugrivastigmineintermsofbehavioral,biochemical,andmolecularaspects.
简介:目的评估A型肉毒毒素治疗Meige’s综合征的疗效。方法对A型肉毒毒素治疗的30例Meige’s综合征患者资料进行回顾性分析。结果30例Meiges’s综合征患者注射A型肉毒毒素后25例完全缓解,5例明显缓解,总有效率100%。起效时间注射当天~第3天。疗效维持平均为5个月。重复治疗有效。局部不良反应轻微、短暂、可逆,无全身不良反应及过敏反应。结论A型肉毒毒素局部注射是治疗Meige’s综合征的一种安全、有效、简便、易行的方法。
简介:AIM:ToexaminetheprotectiveeffectsofGinkgobilobaextract(GbE)onthelearningandmemoryintheAlzheimerdisease(AD)modelinducedbyaluminumsaltinrats,andtoexaminethepotentialmechanisms.METHODS.TheADmodelofratswasinducedbyadministrationanddrinkingofaluminumchloridesolution.Theabilitiesofspatialleafingand
简介:目的探讨直肠癌术后Mile‘s结肠造瘘的护理分析。方法选择2017年10月-2018年12月运用了直肠癌术后Mile‘s结肠造瘘的患者70例作为对象,随机数字表将患者分为对照组(n=35)和观察组(n=35)。对照组患者运用常规护理方法,观察组患者运用综合的护理方法,1个月后对患者的两组护理后的并发症情况进行评估。结果经1个月护理后;观察组患者瘘口感染症状,瘘口粘膜水肿症状,以及瘘口狭窄症状显著低于对照组(P<0.05)。结论对运用了直肠癌术后Mile‘s结肠造瘘的患者进行综合护理,有助于降低患者治疗后并发症的出现,整体上有助于患者的康复治疗,值得推广应用。
简介:目的:探讨经腹腔镜剥脱式胆囊切除术的术式改进。方法:我们利用分离钳电凝剥脱法解剖胆囊管和胆囊动脉,电凝铲电凝剥离胆囊床。处理Calot三角解剖关系清楚,避免误伤胆总管,同时避免高频电刀热电效应对胆肠及内脏的损伤。通过临床随机32例经腹腔镜剥脱式胆囊切除的手术实践,分析其技术改进原理及避免并发症发生的价值。结果:无中转开腹,全部病人均顺利完成手术。多数术后2天痊愈出院,最长时间为术后6天。术后肠胀气1例,恶心呕吐4例,肩背痛5例,心绞痛1例,室速1例。无手术死亡。结论:经腹腔镜剥脱式胆囊切除,无中转开腹,手术并发症少,无手术死亡,术后恢复良好,效果满意。该术式操作简便,安全,快速,易掌握,与电钩电凝法相比,具有明显优势。