简介:StudyoncorrelativityamongcapacitydimensionD0,infor-mationdimensionD1,algorithmiccomplexityC(n)andbValueWEI-BINHAN(韩渭宾),GUI-X...
简介:Cytarabine(1-β-D-arabinofuranosylcytosine,Ara-C),isolatedfromaCaribbeanspongespeciesTethyacrypta,isthefirstantitumordrugfromamarineresource.In1980,theUSFoodandDrugAdministrationapprovedthisdrugforthetreatmentofdifferenttypesofleukemia.Thisdrughasashortplasmahalf-life,lowstability,limitedbioavailability,andseveresideeffects.Toimprovestabilityandbioavailability,wesynthesizedninenovelderivativesbyblockingthecytarabinemetabolicsitesandimprovinglipophilicity.ThecLogPvaluesofthenewlysynthesizedcompoundswerecalculated.Allthesynthesizedcompoundsweremorelipophilicthancytarabine,resultinginmembranepermeabilityandbioavailabilityimprovement.TheantitumoractivitiesagainstleukemiacelllineHL-60wereevaluatedbyusingtheMTTassay.ThebioassayresultsrevealedthattheIC50valuesofcompounds5,8and9were0.080,0.090and0.057μmolL-1,respectively,whichwassimilarwiththatofcytarabine(0.056μmolL-1).Incomparison,compound4withaphosphategroupatO5’wasinactive.Becausephosphoesterbondsareeasilyhydrolyzedbyalkalinephosphataseandarecommonlyusedinproducingprodrugstrategies,compound4mightalsobemetabolizedinvivoandgeneratecompound3orevencytarabinethroughamulti-stepreaction.Thus,compound4mightbeapromisingcompoundtobedevelopedasaprodrug.
简介:完整的波形倒置(FWI)直接最小化在合成、观察的数据之间的错误。为表面获得几何学,从深反射镜产生的思考是敏感的压垂组织,因此更新宏速度模型在是合理的一从上到下举止。为水平地分层的结构统治的模型,偏移量/时间weighting和经常的更改深度控制(CUDC)的联合为剥去层的FWI是足够的。CUDC要求光线跟踪在经常的深度决定思考traveltimes。作为模型复杂性增加,多路径效果将不得不被考虑。我们开发了利用抑制地震思考数据的一个新剥去层的FWI方法,它不需要CUDC并且光线跟踪。数字例子证明有效更改深度(EUD)能被甚至在复杂区域抑制常数控制,倒置结果比常规方法更精确。
简介:与极化单人赛的合成的孔相比,雷达(SAR)想象,完整的测定偏振的SAR图象包含不仅几何、向后散布的特征,而且散布目标的极化特征。因此,测定偏振的SAR在海表面上为油喷洒察觉有更多的优点。作为在油喷洒察觉的关键步,特征抽取直接影响油喷洒辨别的精确性。海油喷洒的测定偏振的特征例如测定偏振的熵,平均散布角度,在完整的测定偏振的SAR图象第一被分析。并且反映在布拉格和镜子的散布信号之间的比例的新测定偏振的参数P被建议。为了为观察multipolarization的油喷洒,系统的比较和分析调查测定偏振的特征的能力,特征根据SIR-C/X-SAR和Radarsat-2获得的完整的测定偏振的SAR图象被提供。在C乐队SAR图象,油流出的实验结果表演能比在L乐队SAR想象在下面的更容易被检测对中等的风速度条件低。而且,它也发现新测定偏振的参数对散布机制的海表面敏感。并且实验结果证明新测定偏振的参数和柱脚高度在C乐队SAR图象为油喷洒察觉比另外的测定偏振的参数更好表现。
简介:地震照明在表面下的成像起一个重要作用。一幅更好的图象也能通过优化获得几何学或介绍包含照明赔偿的更先进的地震移植或tomographic倒置方法被期望。垂直电报调查是为它的灵活性和数据质量的传统的海洋的地震调查的潜在的代替。处理的常规垂直电缆线数据在移植前要求primaries和multiples的分离。我们建议使用多尺度的完整的波形倒置(FWI)改进垂直电报调查的照明范围。一个深水速度模型被造在在海床下面检测低速度异例测试多尺度的FWI的能力。合成结果证明多尺度的FWI是在深海的探索的一个有效模型大楼工具。通过面向的照明分析和多尺度的FWI可以帮助减轻垂直电报调查的风险的目标的几何学优化。多尺度的FWI,低频率的数据和multi-vertical-cable获得系统的联合可以提供高分辨率和高保真度表面下的模型。
简介:Tenfull-scalesteelbeam-to-columnmomentconnectionsusedinmoment-resistingframes(MRFs)weretestedtostudythefailureprocess,failuremode,strengthandplasticrotationcapacity.Thespecimensincludeonetraditionalweldedflange-boltedwebconnection,onetraditionalfullyweldedconnection,fourbeamflangestrengthenedconnections,threebeamflangeweakenedconnections,andonethrough-diaphragmconnection.ThetestresultsshowthattheconnectionswithflangecoverplatesorwithpartlycutbeamflangessatisfythebeamplasticrotationdemandforductileMRFs.Fromthemeasuredstressprofilesalongthebeamflangeandbeamwebdepth,themechanicsofbrittlefractureattheendofthebeamisdiscussed.Designrecommendationsforsteelbeam-to-columnmomentconnectionsareproposed.
简介:通常一个维(1-D)实验咸度侵入模型被限制到自然冲积河口。然而,这研究试图调查它的能力在马来西亚为Terengganu河的一个掩盖的冲积河口建模。在河的嘴的构造防波提从公海的直接影响掩盖河口。沿着河口的咸度密度被收集在期间湿并且为在构造防波提前后的情形的旱季。而且,淡水分泌物,潮汐的举起和深测术数据也作为模型输入被测量。一好合适在模仿并且观察的变量之间被表明,也就是为两种情形的咸度分发和侵入长度。因此,结果显示出那1-D实验咸度模型能在Terengganu河口为掩盖的河口状况被利用,但是与一个起始的点的一颗适当决心。而且,在学习区域的咸度侵入大部分依赖于淡水分泌物而非潮汐的举起变化,这被观察。在学习区域的咸度侵入长度的规模与the-1/2力量的河分泌物成正比。实验咸度模型和分泌物驱动的1-D的二根线基于适合很好到对方的方程,这被显得,与150的平均预言的最小的淡水分泌物,m3/s将被要求在水吸入车站附近在高水位线呆滞(HWS)期间维持可接受的咸度层次,它从河嘴在10.63km被定位。
简介:Full-rangenonlinearanalysisoffatiguebehaviorsofreinforcedconcretestructuresbyfiniteelementmethod¥SongYupu;ZhaoShunbo;WangRuim...
简介:Aseriesofshake-tabletestswasconductedbyinsertingandreplacing4differenttypesofdampers,orbyremovingtheminafull-scale5-storysteelframebuilding.Theobjectiveistovalidateresponse-controltechnologiesthatareincreasinglyadoptedformajorJapanesebuildingswithoutbeingattestedto-datebyamajorearthquake.Testresultsarebrieflydescribed,andgoodperformanceofthedampersandframedemonstrated.Theconceptsofthefull-scalebuildingtestsandvariouscontributionsarediscussed.Thedifficultyassociatedwithfull-scaledynamictestingisexplained.
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简介:Athree-dimensionalrigidbodyontheshapeofaparallelepipedismodelledinordertorockonasideoravertexofthebase,inordertoevaluatetheseismicresponseofrigidblockslyingonahorizontalsupport.Thecenterofmassofthebodyisconsideredaseccentricwithrespecttoitsgeometriccenter.Asseismicinput,threeItalianrecordedaccelerograms,withdifferentspectralcontent,areused.Thestudyismainlyconductedtohighlightthedifferencesbetweentheseismicresponseof2Dand3Dmodelsofrigidblocks,withtheaimtounderstandif,insomecases,theuseofthe3Dmodelofrigidblockisrequiredtoobtainsaferresults.Infact,theoutcomesshowthatinsomerangesofthegeometricalandmechanicalparametersthatcharacterizetheexcitationandthebody,atwo-dimensionalmodel,whichisnotabletoconsiderthe3Drockingonavertex,canprovideunsaferesults.Inparticular,itisfoundthattheoverturningprocessofthethree-dimensionalblockcanoccurunderexcitationswhicharelowerthanthosewhichoverturnacorrespondingtwo-dimensionalblock.