简介：Non-smallcelllungcancer(NSCLC)accountsfor85%oflungcancer,whichistheleadingcauseofdeathinlungcancerpatient.RoutinetreatmentofNSCLCcannoteffectivelychangethesurvivalrateofpatients,oneimportantreasonistheincreasedradioresistanceoftumorcellsafterconventionalradiotherapy.

简介：TodepictthedetailsthatCHOP(C/EBPhomologousprotein)regulatesautophagyandapoptosisinbreastcancercells,theexpressionofCHOPwasinhibitedbytransfectionwithsiRNAsequence.AsshowninFig.1,radiati-Fig.1CHOPinhibitionbysiRNAatmRNAandproteinlevelsafterradiation.onelicitedahigherexpressionofCHOPintheNCgroupcomparedwithcontrol.However,thishigherexpressionwassignificantlyinhibitedinthesiRNAgroup.

简介：Receptor-ligandinteractionsinbloodflowarecrucialtoinitiatesuchbiologicalprocessesasinflammatorycascade,plateletthrombosis,aswellastumormetastasis.Tomediatecelladhesion,theinteractingreceptorsandligandsmustbeanchoredontotwoapposingsurfacesoftwocellsoracellandasubstratum,i.e.,two-dimensional(2D)binding,whichisdifferentfromthebindingofasolubleligandinfluidphasetoareceptor,i.e.,three-dimensional(3D)binding.Whilenumerousworkshavebeenfocusedon3Dkineticsofreceptor-ligandinteractionsintheimmunesystem,2Dkineticsanditsregulationshavebeenlessunderstood,sincenotheoreticalframeworkorexperimentalassayswereestablisheduntil1993.Notonlydoesthemolecularstructuredominate2Dbindingkinetics,buttheshearforceinbloodflowalsoregulatescelladhesionmediatedbyinteractingreceptorsandligands.Here,weprovideanoverviewofcurrentprogressin2Dbindingandregulations,mainlyfromourgroup.Relevantissuesoftheoreticalframeworks,experimentalmeasurements,kineticratesandbindingaffinities,andforceregulationsarediscussed.

简介：某些疾病被知道引起变化在物理并且房间的biomechanical性质。这些在其它之中包括癌症，疟疾，和镰刀房间贫血症。典型地，如此的物理性质变化能导致房间僵硬的几褶层增加或减少，它是重要的并且能导致严重病理和最终的灾难的故障身体功能。当有时开发了生物化学、生物的试金检测疾病的发作或存在，总是有需要开发更快速、精确、敏感的方法检测并且诊断疾病。Biomechanical性质变化能起一个重要作用在这方面。因此，对疾病biomechanics的研究不能仅仅给我们位于疾病前进下面的机制的深入的知识，但是能也为察觉和诊断用作一个强大的工具。这篇文章提供一些卓见进机会因为在疾病的发作或前进期间在细胞的机械性质换掉怎么重要，能为察觉和诊断作为有用工具被利用。我们将也展示已经被开发了执行如此的察觉和诊断的几种技术。

简介：在这份报纸，我们使用任意的Riemann解答者，它不能满足Maire的要求，到Maire发展在的基于节点的Lagrangian计划[P.H。Maire等，暹罗J。Sci。Comput，29(2007)，1781-1824]。特别地，我们使用所谓的多液体隧道onAveraged体积(MFCAV)Riemann解答者和适应地把MFCAV解答者与另外的更消散的Riemann解答者相结合到Maire的计划的一个Riemann解答者。任何一个二个解答者都不满足Maire的要求，这被注意。数字实验被介绍证明二个Riemann解答者的应用程序是成功的。[从作者抽象]

简介：Nafion-stabilizedPtnanoparticlecolloidalsolutionissynthesizedthroughethyleneglycolreduction.Pt/Nafionaddedwithcarbonblackaselectricconductionmaterial(labeledPt/Nafion-XC72)showsexcellentelectrochemicalpropertycomparedwithPt/C.Aftera300-cycledischargingdurabilitytest,thecellperformanceofmembraneelectrodeassembly(MEA)withthePt/Nafion-XC72andPt/Ccatalystsindicatesa29.9%and92.2%decrease,respectively.ThechargetransferresistancesofPt/Nafion-XC72andPt/Cincreaseby27.2%and101.9%,respectively.TheremainingelectrochemicallyactivesurfaceareaofPtisabout61.7%inPt/Nafion-XC72andabout38.1%inPt/Cafterthedurabilitytest.TheparticlesizeofPt/Cincreasesfromabout5.1nmtoabout10.8nmbutonlyfrom3.6nmto5.8nminthecaseofPt/Nafion-XC72.ThesedatasuggestthatPt/Nafion-XC72asacatalystcanenhancethedurabilityofPEMFCscomparedwithPt/C.

简介：Recently,RNAprocessinghasemergedasanovelpathwaythatmaycontributetothemaintenanceofgenomestability[1].Alternativesplicingisakeymolecularmechanismforincreasingthefunctionaldiversityoftheeukaryoticproteomes,butitalsooftenalteredincancer.Mountingevidenceindicatesthatalternativesplicing,theprocessthatallowsproductionofmultiplemRNAvariantsfromeachgene,contributestotheheterogeneityofthedisease[2].Althoughthemechanismofalternativesplicingvariantincancerisunclear,thecancer-specificalternativesplicingvariantshavebeenobservedinavarietyofhumancancersandcancercelllinesandhavebeenconnectedtotumorgenesis.

简介：Radiotherapy,astandardadjuvanttosurgery,improvessurvivalratesinpatients,butresistancetotreatmentbysomegliomaslimitsthesuccessofclinicalapplication.Emergingevidenceindicatesthatthetumormicroenvironmentcontributestoradiationresistancebyregulatingthelevelsofcytokinesandgrowthfactors[1;2].

简介：Intrinsicapoptosis,apossibleresponsetomitochondrialdamage,inMDA-MB-231cellsexposedtodifferentdosesofcarbonionswasinvestigatedinthisstudy.WeassessedBaxandBcl-2expressionandcytochromecreleaseinthemitochondriaandcytosolofcellsexposedtolow(0.5Gy)andhigh(3Gy)dosesofcarbonionsusingwesternblotanalysis.

简介：

简介：Wedevelopadualporous(DP)TiO_2filmfortheelectrontransportinglayer(ETL)incarboncathodebasedperovskitesolarcells(C-PSCs).TheDPTiO_2filmwassynthesizedviaafacilePS-templatedmethodwiththethicknessbeingcontrolledbythespin-coatingspeed.ItwasfoundthatthereisanoptimumDPTiO_2filmthicknessforachievinganeffectiveETL,asuitableperovskite/TiO_2interface,anefficientlightharvesterandthusahighperformanceC-PSC.Inparticular,suchaDPTiO_2filmcanactasascaffoldforcomplete-fillingoftheporeswithperovskiteandforforminghigh-qualityperovskitecrystalsthatareseamlesslyinterfacedwithTi_O2toenhanceinterfacialchargeinjection.LeveragingtheuniqueadvantagesofDPTiO2ETL,togetherwithadense-packedandpinhole-freeTiO_2compactlayer,PCEoftheC-PSCshasreached9.81%withgoodstability.

简介：Basicmagnesiumcarbonatemicrosphereswitharedbloodcell（RBC）-likeappearanceanddiametersof3μmweresynthesizedbyamphiphilicmolecule-participatedself-assemblyunderhydrothermalconditions.Intheself-assembly,sodiumdodecylbenzenesulfonateservedasatemplatefortheformationofMg（OH）2sphericalmicellesandalsoasareactantprecursorthatreleasesCO2toreactwithMg（OH）2.Thegrowthofthemicrospheresisdrivenbythecontinuousgenerationofnewhydrophobiccentersbecauseoftheconsumptionofhydrophilicpoles（—SO3-）.Thesurfactant-directedself-assemblycanbeappliedtothesynthesisofothercarbonateormetallicoxideself-assemblies,indicatingthatitisauniversalself-assemblymethodforamphiphilicmolecules.

简介：AlterationsinDNArepair,cellcycle,andapoptoticpathwaysareoftenassociatedwithcancerriskandradiationsensitivity.IndividualswithreducedDNAdamageresponsefaceagreatersensitivitytomutagenchallenge.Interindividualvariabilityinmutagenorradiationsensitivityandincancersusceptibilitymayalsobetracedbacktopolymorphismsofgenesaffectinge.g.DNArepaircapacity[1].

简介：cJUNNH2-terminalkinase(JNK)hasbeenreportedtoplayimportantrolesinregulatingthecellularapoptosisandautophagy.However,accuratemechanismandhowthebalanceoftheseactivitiesdeterminesthecellularradiosensitivityremainunclear.

简介：Theelectrontransportlayer(ETL)playsanimportantroleinplanarheterojunctionperovskitesolarcell(PSCs),byaffectingthelight-harvesting,electroninjectionandtransportationprocesses,andespeciallythecrystallizationofperovskiteabsorber.Inthiswork,weutilizedacommercialTKD-TiO_2nanoparticlewithasmalldiameterof6nmforthefirsttimetoprepareacompactETLbyspincoating.Thepackingofsmall-sizeparticlesendowedTKD-TiO_2ETLanappropriatesurface-wettability,whichisbeneficialtothecrystallizationofperovskitedepositedviasolution-processedmethod.Theuniformandhigh-transmittanceTKD-TiO_2filmsweresuccessfullyincorporatedintoPSCsasETLs.FurthercarefuloptimizationofETLthicknessgavebirthtoahighestpowerconversionefficiencyof11.0%,whichwasmuchhigherthanthatofPSCusinganETLwiththesamethicknessmadebyspraypyrolysis.ThisTKD-TiO_2providedauniversalsolarmaterialsuitableforthefurtherlarge-scaleproductionofPSCs.TheexcellentmorphologyandtheconvenientpreparationmethodofTKD-TiO_2filmgaveitanextensiveapplicationinphotovoltaicdevices.

简介：Tonguesquamouscellcarcinoma(ToSCC)isthemostcommontypeofheadandnecksquamouscellcarcinomaandisthesixthleadingcauseofcancerdeathsworldwide[1].Inclinicaloncology,radiationtherapyisastandardtreatmentusedfortumors.Numerousstudieshaveshownthatconventionalradiotherapyusedincancertreatmentmayincreasetheriskofmetastasisofmalignanttumorcells[2–4].Toimprovepatientsurvival,thepotentialformetastasisoftumorsinresponsetoradiationneedstobeaddressed.

简介：Li4Ti5O12（LTO）/carbonnanotubes（CNTs）compositematerialissynthesizedbasedonasolid-statemethodbysand-milling,spray-dryingandcalciningat8508CunderN2flow.TheLTO/CNTssampleswith1wt%and3wt%weightratioofCNTsadditionandthepristineLTOsampleareprepared.TherateperformanceandthethermalstabilityofthesesamplesareinvestigatedbasedonLiMn2O4（LMO）/LTOfull-cell.TheresultsshowthattheweightratioofCNTsadditionhasdistincteffectonLTOperformances.ThecompositematerialsofLTOcompositedCNTshavebetterperformanceathigh-rateduetotheintercalationenhancementbyconductivenetworkofCNTs.Atsecond,theoverchargingtemperatureresponseofthecell’ssurfacewith1wt%CNTsadditionisthelowest.Theparticlesizedistributionismeasuredandthemostuniformparticlesareobtainedwith1wt%CNTsaddition.ThistrendcouldexplainthatthemediumquantityofCNTsisoptimaltoimprovetheheatandmasstransferandpreventtheproblemsofcrystallitegrowinginterferenceandaggregationduringthecalcinationprocess.