简介:Thelabellingandimagingoftumorcellswereinvestigatedviaarginine-glycine-asparticacidcysteine(RGDC)peptide-labelledquantumdots(QDs).TheresultsshowthatRGDCmodifiedQDscanlabelSMMC-7721tumorcellsandadheretocellularmembrane.Inconstrast,theunmodifiedQDsaremainlydispersedaroundthecell.WealsofoundthattheRGDC-QDscanpenetrateintothecellat2hofincubation.After6hofincubation,RGDC-QDscanaccumulateinauniqueintracellularregion.
简介:Polyethylenimine-polyL-lysinePEI-PLL共聚物经由PEI开始的L离氨酸N-carboxyanhydrideLysZ-NCA的戒指洞聚合被综合。有siRNA的PEI-PLL的complexation被粒子尺寸和希腊语的第六个字母潜力大小学习。流动cytometric分析和共焦的成像显示出它的优秀细胞内部的trafficking能力。PEI-PLL在vitro比商业PEI-25k显示了更高的基因silencing效率和更低的cytotoxicity。在antitumor学习,PEI-PLL进一步与siVEGF被相结合并且显然为CT26肿瘤模型的处理显示出肿瘤抑制效果。因此,PEI-PLL是在vivo的进一步的antitumor处理的一个有希望的siRNA搬运人候选人。
简介:ThisworkdemonstratestheNd:YAGwaveguidelaserasanefficientplatformforthebio-sensingofdextrosesolutionsandtumorcells.ThewaveguidewasfabricatedinanNd:YAGcrystalwiththecooperationofultrafastlaserwritingandionirradiation.ThelaseroscillationintheNd:YAGwaveguideisultrasensitivetotheexternalenvironmentofthewaveguide.Evenaweakdisturbanceleadstoalargevariationoftheoutputpowerofthelaser.Accordingtothisfeature,anNd:YAGwaveguidecoatedwithgrapheneandWSe2layersisusedassubstrateforthemicrofluidicchannel.WhenthemicroflowcrossestheNd:YAGwaveguide,thelaseroscillationinthewaveguideisdisturbedandinducesfluctuationoftheoutputlaser.Accordingtothefluctuation,themicroflowisdetectedwithasensitivityof10mW/RIU.
简介:Theextinctionphenomenoninducedbymultiplicativenon-GaussianL′evynoiseinatumorgrowthmodelwithimmuneresponseisdiscussed.Undertheinfluenceofthestochasticimmunerate,themodelisanalyzedintermsofastochasticdifferentialequationwithmultiplicativenoise.BymeansofthetheoryoftheinfinitesimalgeneratorofHuntprocesses,theescapeprobability,whichisusedtomeasurethenoise-inducedextinctionprobabilityoftumorcells,isexplicitlyexpressedasafunctionofinitialtumorcelldensity,stabilityindexandnoiseintensity.Basedonthenumericalcalculations,itisfoundthatfordifferentinitialdensitiesoftumorcells,noiseparametersplayoppositerolesontheescapeprobability.Theoptimallyselectedvaluesofthemultiplicativenoiseintensityandthestabilityindexarefoundtomaximizetheescapeprobability.
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简介:指向nano探查基于的一个可被细菌破坏的肿瘤poly(?-caprolactone)-b-poly(ethylene乙二醇)有磁性的回声成像(MRI)的块共聚物(PCL-b-PEG)micellefunctionalized对比代理人diethylenetriaminepentaacetic酸金轧(DTPA-Gd3+)在壳上并且一在红外线附近(NIR)在为磁性的回声和光双形式的成像的核心的染料是准备。纵的relaxivity(r1)PCL-b-PEGDTPA-Gd3+,micelle是13.4(mmol/L)?1s?1,DTPA-Gd3+的三褶层,并且比有类似的结构的许多聚合对比代理人的高。在里面忍受xenografted胸肿瘤的一只裸体老鼠的光成像显示出的vivo双形式的micelle优先地经由folic在肿瘤积累了由提高的渗透和保留(EPR)效果的调停酸的活跃指向和被动累积。结果显示dualmodalitymicelle是为癌症察觉和诊断的有希望的nano探查。
简介:BecauseERstressisoneofthesignalingpathwaysinvolvedintheregulationofautophagy,wehypothesizedthatERstressmightalsoplayanimportantroleinradiation-inducedautophagy.SHG44andHeLacellswereirradiatedwithX-raysandcarbonionsof30and75keV/mat2Gy.TheexpressionlevelsofBip,amajorindicatorofUPR,at4and24hpost-irradiationareshowninFig.1(a)and(b)forSHG44andHeLacells,respectively.