简介:Afacileone-potsynthesisofα-cyclodextrin-basedpolyrotaxane(PR)inaqueoussolutionisreported,wherethepeptideglutathionewasusedastheend-cappingagentandthethiol-eneMichaeladditionwasusedastheend-cappingreaction.Bothpolyrotaxaneswithlowthreadingratioandhighthreadingratioweresuccessfullyobtained.Incontrasttotheconventionallyusedmultiple-stepsynthesismethodsandhydrophobicendcappers,thisone-potaqueoussynthesisaswellasthebiocompatibilityoftheend-cappingagentcouldresultinamuchmorebiocompatiblePRtobeusedasbiomaterials.
简介:基本上在在vitro和细胞外的矩阵种相关房间上面做的织物工程。织物工程的一个主要目标到preparate多孔为房间的三尺寸脚手架增殖,移居,differention并且形成理想的织物和机关的结构。在这研究,各种各样的内容的效果和到chitosan的木钉的macromolecular重量被调查并且评估。chitosan的毛孔形态学被改变集中控制,PEG.Chitosan多孔的支架的macromolecular重量有interconecting孔。毛孔形态学能与改变木钉集中和macromolecular重量被控制。毛孔尺寸在之间1050嗯,在水里胀大的度是85.70%。
简介:Injectablenanoparticlecarrier,poly(ethyleneglycol)-coatedpoly(ethylcyanoacrylate)hasbeenpreparedbyasimplemethod.AtFirst,synthesizingPEGmacromonomerofpoly(ethyleneglycol)monomethyletherwithacryloylchloride,thengraftcopolymerofpoly(ethylcyanoacrylate)andpoly(ethyleneglycol)wasyieldbyfreeradicalpolymerizationofethylcyanoacrylatewithPEGmacromonomerintoluenesolvent.CharacterizationofthecopolymerhasbeenperformedbyFTIR,1H-NMRandGPCanalysis.Nanoparticleswereeasilypreparedfromtheobtainedamphiphiliccopolymer.
简介:摘要目的研究乙交酯-丙交酯-聚乙二醇(PEG-PLGA)载药微球制备因素对外观形态、载药量和包封率的影响,制备符合要求的多孔载药微球。方法以乙交酯(GA)、L-丙交酯(LA)和聚乙二醇(PEG)为原料制备PEG-PLGA;以二氯甲烷为有机相,用W/O/W复乳法制备包封伊文思蓝的PEG-PLGA多孔载药微球。以微球外观形态、载药量和包封率为参考指标,对制备因素温度、聚合物浓度和聚合物各组分摩尔比进行优化。结果优化条件后最佳组合温度40℃(二氯甲烷的沸点),浓度为75mg/ml,聚合物各组分摩尔比为63/27/10。此时微球为多孔结构,成球规整,孔隙均匀,载药量和包封率相对较高,分别为0.38%和32.41%。结论制备温度、聚合物浓度和聚合物各组分摩尔比对载药微球的外观形态、载药量和包封率有较大影响。
简介:SAPO-34,asilicoaluminophosphatezeolite,hasbeensynthesizedbythehydrothermalmethodwiththeadditionofdifferentmolecularweightsofpolyethyleneglycol(PEG),andhasbeencharacterizedwithXRD,SEM,N2adsorption-desorption,FT-IR,andNH3temperatureprogrammeddesorption(NH3-TPD).WestudiedSAPO-34asacatalystinthemethanol-to-olefins(MTO)reaction,inafixed-bedreactor.TheresultsshowthatthechainlengthofPEGhasagreatinfluenceontheparticlesizeandmorphologyofSAPO-34.PEGactsasinhibitorinthecrystallizationprocess.WiththeincreaseofthechainlengthofPEGusedinthesynthesis,fromarelativemolecularweightof400-6000,themorphologyofSAPO-34changesgraduallyfromcubictonanoplate-likeandthenchangestocubicagain.Theparticlesizedecreasesmarkedlyatfirstandthenincreasestosomeextent.ThecatalyticstabilityintheMTOreactionalsoincreasesfirstandthendecreases,withallthecatalystshavingalmostthesameselectivitytoolefins.WhenthesampleissynthesizedwithPEG800,theparticlesbecomenanoplate-likewithathicknessof46nmonaverage,andthecatalyticstabilityisappreciablyprolonged,whichisattributedtotheshorterdiffusionpathsofthereactantsinthezeolite.
简介:NanocrystallineanataseTiO2filmswithindiumtinoxide(ITO)coatedglassasthefilmsubstratewerefabricatedthroughspin-coatingtechnique.TheTiO2pasteswerepreparedwithsodiumdodecylbenzenesulfonate(DBS)modifiedTiO2nanocrystals,synthesizedbysol-hydrothermalprocessesinadvance,togetherwithdifferentamountsofpolyethyleneglycol(PEG)macromolecules.Theas-preparedfilmsweremainlycharacterizedbyultraviolet-visible(UV-Vis)spectroscopy,fieldemissionscanningelectronmicroscopy(FE-SEM)andwatercontactangle(WCA)measurement.EffectsoftheadditionofDBSandPEGonthewettingperformanceoftheresultingfilmsandrelevantmechanismswereprincipallyinvestigated.Theresultsshowthattheas-preparedfilmdisplayssuper-hydrophilicpropertyafterco-additionofDBSandPEGalthoughitisnotexposedtoultravioletlightpriortotheWCAmeasurement.Thisappealingresultismainlyattributedtotheproducedmicroandnanometer-scalehierarchicalsurfacestructurewithuniformlydispersedmicropapillae.EachpapillawasmadeupofagreatnumberofTiO2nanoparticles.ThepossibleformationmechanismsrelatedtotheDBSamphiphilicpropertyofthecharacteristicsurfacewerealsosuggested.Moreover,theresultingfilmalsoexhibitsconsiderabledurabilityinthesuperhydrophilicity,whichisveryusefulforpracticalapplicationinself-cleaning,anti-fogging,andbacteria-resistantfields.
简介:TherecyclablePEG-boundbi-cinchonaalkaloidligandhasbeensuccessfullyappliedtothehomogeneouscatalyticasymmetricdihydroxylationofvariousalkenes;goodyieldsandexcellentenantioselectivitieswereobtained,Theligandcouldbeeasilyrecoveredandreusedfor10timeswithoutanyapparentlossofitscatalystefficiency.
简介:本研究对聚乙二醇(polyethyleneglycol,PEG)的分子量、浓度及处理时间等三个影响番木瓜叶肉原生质体转化效率的主要因素进行了优化,同时利用绿色荧光蛋白(greenfluorescentprotein,GFP)表达体系进行了转化表达分析。结果表明:经40%PEG8000溶液处理10min,可使GFP在原生质体中的平均转化率达到45.26%;沉默抑制载体pGreen-Hcpro和GFP瞬时表达载体共转化番木瓜叶肉原生质体,可使GFP在原生质体中的平均转化率进一步提高到68.75%,相比单独转化瞬时表达载体pRNAi-GFP增长了51.90%。PEG介导番木瓜叶肉原生质体瞬时表达体系的建立为番木瓜功能基因组和基因功能研究奠定了基础,可为热带作物的研究提供又一模式作物,推动热带作物在分子及细胞生物学领域的发展。
简介:文章以聚乙二醇2000衍生化二硬脂酿嶙脂酰乙醇胺(PEG2000-DSPE)为载体,采用薄膜分散法制备前列地尔(PGE1)肢束,评价其制剂学性质;并对其大鼠体内分布及金黄地鼠微循环血管药理作用进行研究.实验结果表明PGE1胶束在大鼠体内生物利用度和各组织含药量方面均高于PGE1注射剂;PGE1肢束对微血管作用强于PGE1注射剂,可显著降低血压、维持管径和血流速度并增强微血管自律运动.