简介:摘要目的分析男性不育患者年龄与精液参数的相关性,探讨年龄对男性生育力的影响.方法将1458例男性不育患者按照年龄分为3组,<30岁组(n=783),30~40岁组(n=573)和>40岁组(n=102),根据WHO标准(2010版)进行精液常规检查和精子形态分析,比较各年龄组精液参数的差异,分析年龄与精液各参数的相关性.结果各年龄组精子浓度、存活率、活力和形态正常率无显著差异.年龄与精子存活率(r=-0.227,p<0.05)和精子活力(r=-0.326,p<0.05)均呈负相关关系,但与精液量、精子浓度及形态正常率无相关性;精子浓度与精液量(r=-0.253,p<0.01)呈负相关关系,与精子存活率(r=0.314,p<0.05)和精子活力(r=0.288,p<0.05)均呈正相关关系;精子形态正常率与精子存活率(r=0.163,p<0.05)和精子活力(r=0.472,p<0.05)均呈正相关关系.结论男性不育患者随着年龄增长,精子存活率和活力可能下降,进而影响生育力.提示男性亦有合适的生育年龄,建议适龄生育和及早就医治疗.关键词男性不育;年龄;精液参数;精子形态;相关分析CorrelationbetweenAgeandSemenParametersAnalysesof1458InfertileMenLiRun,HeWei,ZhengJie,etal.(MianyangCentralHospital,Mianyang,SiGchuan621000,China.)AbstractObjectiveToanalyzethecorrelationbetweenageandsemenparametersofinfertilemales,andexploretheeffectofageonmalefertilety.Methods1458c(asesofinfertilemalesweredividedbyageintothreegroups,<30yearsold(n=783),30~40yearsold(n=573),>40yearsold(n=102).BasedonWHOcriteria2010),semenconventionalandspermmorphologyanalysiswereperformed.Comparedthedifferenceofsemenparametersindifferentagegroups,andtoanalyzethecorrelationbetweenageandsemenparameters.ResultsThereisnosignificantdifferenceofspermconcentration,viability,motilityandmorphologyamongthe3groups.Agenegativelycorrelatedwithspermviability(r=-0.227,p<0.05)andspermmotility(r=-0.326,p<0.05),butirrelatedtosemenvolume,spermconcenGtrationandspermmorphology.Therewasasignificantnegativecorrelationbetweenspermconcentrationandsemenvolume(r=-0.253,p<0.01),butspermconcenGtrationpositivelycorrelatedwithspermviability(r=0.314,p<0.05)andspermmotility(r=0.288,p<0.05).spermmorphologypositivelycorrelatedwithspermviaGbility(r=0.163,p<0.05)andspermmotility(r=0.472,p<0.05).ConclusionThespermviabilityandspermmotilitymaydecreasewithageofinfertilemales,andthenefKfeecytwfeorrtdilsity.Itmeansthatthereisalsosuitablereproductiveageformale,betterwayisrighttimetoreproductiveandearlymedicaltreatment.maleinfertility;age;semenparmeters;spermmorphology;correlationanalysis中图分类号R697文献标识码B文章编号1008-6315(2015)12-0779-02