简介：摘要：生态文明建设功在当代、利在千秋。蓬莱秉持“绿水青山就是金山银山”的价值理念，不断加大力度推进生态文明建设、解决生态环境问题，着力构建人与自然和谐发展现代化建设新格局，走出一条“绿色蓬莱”的发展之路。。

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简介：摘要：《渤海国志长编》是金毓黻历经10年心血所写的一部关于渤海国史的重大著作。渤海国政权在历史上影响比较大，因此，对于它的研究也一直是中外学术界关注的焦点，研究渤海国的历史和文化对于研究中国东北部的历史和文化发展及汉文化在中国东北地区的传播都有极其重要的意义。

简介：【摘要】目的：分析Galectin-3、CK19和TPO表达对甲状腺良恶性肿瘤诊断的价值。方法：择60例甲状腺肿瘤患者（良恶性各30例），分别对Galectin-3、CK19和TPO表达及联合检测进行分析。结果：联合检测特异度、敏感度与准确度均优于单一诊断结果。结论：Galectin-3、CK19和TPO表达联合诊断甲状腺良恶性肿瘤，具有显著价值。

简介：摘要目的研究因轻症COVID-19住院的2岁以下患儿的冠状动脉病变发生率及其病程演变情况。方法该项单中心前瞻性研究共纳入29名儿童(19名男孩)，于2021年3月1日至12月30日期间因轻度COVID-19入住希腊大学医院，中位年龄为3月龄，四分位间距(IQR)为1.6~4.3月龄。在症状首次出现后，分别在IQR第19(16~24)天、82(75~89)天和172(163~197)天进行了三次超声心动图检查冠状动脉扩张、退化和改变的比例。结果第一次评估发现3名(10.3%)患儿出现冠状动脉扩张，第二次评估时完全消退。随访数据显示，18/24(75%)病例的冠状动脉出现退化，9/24(31%)患儿的冠状动脉z值变化大于2，18/29(62%)病例在随访的时间段内冠状动脉某个位置发生变化。结论伴随轻症COVID-19出现的冠状动脉一过性轻度扩张可在3个月内完全消退。尚需进一步大样本研究明确儿童COVID-19感染后的冠状动脉扩张程度和病程演变情况。

简介：摘要：自2019年，蓬莱开始了基层职称制度改革。此次基层职称制度改革，推出了“定向评价 定向使用”和“直评直聘”等重磅基层职称改革措施，深受基层专技人员欢迎。随着改革的深入、政策的落实，实践中评价标准不合理等其他问题逐渐显现和突出。本文通过介绍蓬莱地区改革实践，进一步分析基层职称改革在县级存在的问题，意在探讨解决问题的方法和途径。

简介：AbstractForecasting the COVID-19 confirmed cases, deaths, and recoveries demands time to know the severity of the novel coronavirus. This research aims to predict all types of COVID-19 cases (verified people, deaths, and recoveries) from the deadliest 3rd wave data of the COVID-19 pandemic in Bangladesh. We used the official website of the Directorate General of Health Services as our data source. To identify and predict the upcoming trends of the COVID-19 situation of Bangladesh, we fit the Auto-Regressive Integrated Moving Average (ARIMA) model on the data from Mar. 01, 2021 to Jul. 31, 2021. The finding of the ARIMA model (forecast model) reveals that infected, deaths, and recoveries number will have experienced exponential growth in Bangladesh to October 2021. Our model reports that confirmed cases and deaths will escalate by four times, and the recoveries will improve by five times at a later point in October 2021 if the trend of the three scenarios of COVID-19 from March to July lasts. The prediction of the COVID-19 scenario for the next three months is very frightening in Bangladesh, so the strategic planner and field-level personnel need to search for suitable policies and strategies and adopt these for controlling the mass transmission of the virus.

简介：AbstractThe impact of coronavirus disease 2019 (COVID-19) on endometriosis (EM) is currently unclear. Here, we aimed to describe the potential influence of COVID-19 on the pathogenesis, clinical symptoms, and treatment of EM. The cytokine storm caused by COVID-19 may induce the occurrence and progression of EM, and immunosuppression of COVID-19 may help the ectopic endometrium escape from immune clearance. Consequently, the forced social isolation and the cancelation of non-emergency medical treatment during the COVID-19 pandemic aggravate anxiety and psychological pressure, which can aggravate the symptoms related to EM and delay routine medical services.

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简介：AbstractBackground:To date, there is no effective medicine to treat coronavirus disease 2019 (COVID-19), and the antiviral efficacy of arbidol in the treatment for COVID-19 remained equivocal and controversial. The purpose of this study was to evaluate the efficacy and safety of arbidol tablets in the treatment of COVID-19.Methods:This was a prospective, open-label, controlled and multicenter investigator-initiated trial involving adult patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients were stratified 1:2 to either standard-of-care (SOC) or SOC plus arbidol tablets (oral administration of 200 mg per time, three times a day for 14 days). The primary endpoint was negative conversion of SARS-CoV-2 within the first week. The rates and 95% confidential intervals were calculated for each variable.Results:A total of 99 patients with laboratory-confirmed SARS-CoV-2 infection were enrolled; 66 were assigned to the SOC plus arbidol tablets group, and 33 to the SOC group. The negative conversion rate of SARS-CoV-2 within the first week in patients receiving arbidol tablets was significantly higher than that of the SOC group (70.3% [45/64] vs. 42.4% [14/33]; difference of conversion rate 27.9%; 95% confidence interval [CI], 7.7%-48.1%; P = 0.008). Compared to those in the SOC group, patients receiving arbidol tablets had a shorter duration of clinical recovery (median 7.0 days vs. 12.0 days; hazard ratio [HR]: 1.877, 95% CI: 1.151-3.060, P = 0.006), symptom of fever (median 3.0 days vs. 12.0 days; HR: 18.990, 95% CI: 5.350-67.410, P < 0.001), as well as hospitalization (median 12.5 days vs. 20.0 days; P < 0.001). Moreover, the addition of arbidol tablets to SOC led to more rapid normalization of declined blood lymphocytes (median 10.0 days vs. 14.5 days; P > 0.05). The most common adverse event in the arbidol tablets group was the elevation of transaminase (5/200, 2.5%), and no one withdrew from the study due to adverse events or disease progression.Conclusions:SOC plus arbidol tablets significantly increase the negative conversion rate of SARS-CoV-2 within the first week and accelerate the recovery of COVID-19 patients. During the treatment with arbidol tablets, we find no significant serious adverse events.Trial registration:Chinese Clinical Trial Registry, NCT04260594, www.clinicaltrials.gov/ct2/show/NCT04260594?term= NCT04260594&draw=2&rank=1

简介：摘要由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019年冠状病毒疾病（COVID-19）已经在全球多个国家引起大流行，该病毒传染性强、致死率高，部分变异株在病毒传播性、致病性和免疫原性等多方面发生变化。无症状感染和有症状感染的COVID-19患者在免疫特征上存在异质性；不同年龄阶段的COVID-19患者的临床表现也不尽相同。目前无治疗COVID-19的特效药物，疫情控制需依赖新型冠状病毒疫苗的接种，如核酸疫苗、灭活疫苗、病毒载体疫苗、蛋白质疫苗等。本文通过对新型冠状病毒的变异、临床表现、治疗和疫苗等方面文献的复习，展现目前相关研究的进展。

简介：摘要：本教学设计案例围绕 预备单元（Starter Unit 3What color is it ? ）展开。通过复习句型（What’s this/that? It’s an apple. What color is it? t’s red. Spell it ,please.It’s red）谈论物体颜色学习语法（an/a/the），同时训练学生听，说的能力 .本教学设计依据新课程标准要求，通过希沃游戏，大转盘游戏激发学生学习兴趣，采用图片直观教学法， 通过师生练习，小组练习，双人练习呈现新句型（It’s a red apple.The apple is red.），让学生观察发现总结 规律学习语法。通过完成听力任务培养学生抓住关键词寻找答案的听力技能，培养学生好的听力习惯 。同时以教材为本，结合实际，采用小组合作表演培养学生的口语技能和初步写作能力。本教学案例教学手段多样，使用希沃游戏教学，大转盘游戏，图片插入直观教学，图片裁剪，多媒体希沃白版5手机拍照视频上传，音乐剪辑插入播放等多种信息技术教学手段提高学生学习兴趣，调动学生积极性， 尽力让学生全体参与。教学过程中贯穿课程思政的理念，作业设计注重学生能力的培养。

简介：AbstractA large-scale vaccination of coronavirus disease-19 (COVID-19) in adults has been conducted for nearly a year, and there is a growing recognition that immunization for children is also essential. It has been months since emergency use of pediatric COVID-19 vaccine was approved, we reviewed the prevalence and transmission of COVID-19 in children. The prevalence of COVID-19 in children is reduced due to vaccination even in a Delta prevalent period, so an increase in the vaccination rate is needed in children. Although the precise role of children in the transmission requires more research to uncover, they likely played a significant role, according to the available literature. We also described four candidate COVID-19 vaccines for children on their safety and immunogenicity and the impact of severe acute respiratory syndrome coronavirus 2 variants on childhood vaccination. Safety issues on pediatric vaccines post-approval, like adverse events following immunization and adverse events of special interest require studies on long-term and effective regulatory mechanisms.

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简介：【摘要】互联网技术的迅速发展与普及，推动着基础教育新课程改革，面对数字技术带来的全新教学模式，教师们与时俱进，在学习中尝试新的教育技术来提高教学效率，构建高效课堂取得了可喜成绩。美术学科作为美育教育的主要课程，在此大背景影响下，教改实践也取得了一些成效。本文围绕美术学科的教改尝试，从营造情境美、再现情境美、体验情境美、实践后的反思与体会四个方面，浅述互联网在初中美术课堂教学实践中发挥的作用。

简介：摘要：我国渤海油田石油储量巨大，经过数十年的勘探开发，未来产量增长重点逐步聚焦在低渗油气田，其具有开采难度大、投入成本高的特点。单井产能需达到一定程度才可有效保证经济效益，这对钻完井技术提出了较高的要求。

简介：摘 要：随着环渤海经济圈合作和发展逐步进入正轨，为国家贡献了不可估量的经济效益。环渤海经济圈在市场经济的大力推动下，生态环境和资源遭到了严重的破坏。由于，很多企业的经济发展的创新能力不足，无法实现经济增长与生态保护相同步。对此，本文阐述了环渤海经济区域创新经济的发展情况以及经济发展的理念，概述了价值维度和绩效评价指标，进而为减少资源消耗和降低环境破坏提供正面作用，来实现环渤海经济圈经济的可持续性的发展。

简介：AbstractCOVID-19 has been a global health concern since 2019 until date. Global concerted efforts to combat this pandemic has resulted in a number of vaccines distributed across the globe. Although the presence of these vaccines produced quick interventions, dynamic mutation in the causal virus and the continuous evolution of new stains that defy available vaccines has given rise to pertinent questions. The most recent emergence of a new COVID-19 virus variant (omicron), the rapid spread and overwhelming rate of morbidity and mortality has reopened these questions for debate. This commentary summarizes major view on these questions and concludes that multiple approach including social behavioural measures, vaccination and antiviral drug would speed up elimination process.