简介:联接基长度对非离子与阳离子Gemini表面活性剂间相互作用的影响测定了非离子表面活性剂辛基酚醚(简称PEG—TMBPE)与三种阳离子gemini表面活性剂alkanediyl—a,x—his(dimethvldodecvIammon|umbromide)(12-s-12.S=2、4和6)复配体系的表面张力,并用小角度中子散射法测定了胶束的大小与胶团聚集数。结果表明:1)随着gemini表面活性剂连接基长度的增加以及混合体系中辛基酚醚含量的增加,两种表面活性剂之间的协同作用明显增大;2)混合胶束化是热力学自发进行的,混合胶柬的稳定顺觅序为:PEG—TMBPE+12-2—12〈PEG—TMBPE+12—4—12〈PEG—TMBPE+12—6—12。该混合体系的协同效应源于阳离子gemini表面活性剂亲水头基间的静电斥力的减小,是由以下两个因素引起的:1)辛基酚醚含量增加时使gemini表面活性剂亲水头基之间的空间位阻增大;2)12-s-12q3连接基长度增加,使阳离子gemini表面活性剂的疏水性增大,同时使其亲水头基的极性增大。
简介:Humanglioblastomas(GBM)arethoughttobeinitiatedbygliomastem-likecells(GSLCs).GSLCsalsoparticipateintumorneovascularizationbytransdifferentiatingintovascularendothelialcells.Here,wereportacriticalroleofGSLCsintheformationofvasculogenicmimicry(VM),whichdefineschannelslinedbytumorcellstosupplynutrientstoearlygrowingtumorsandtumor
简介:Glioblastomaisoneofthemostangiogenichumantumorsandcharacterizedbymicrovascularproliferations.Abetterunderstandingofglioblastomavasculatureisneededtooptimizeanti-angiogenictherapythathasshownapromisingbutincompleteefficacy.Thepresentstudyexamined48glioblastomasbyCD34endothelialmarkerperiodicacid-Schiff(PAS)dualstainingandfoundnon-endothelialcell-linedblood