简介：FTO基因与2型糖尿病等疾病密切相关，与其他基因发挥协同作用。全基因组关联分析使得FTO（fatmassandobesityassociated）基因成为第一个普通人群肥胖候选基因，其在下丘脑核丰富表达，参与能量平衡的控制。P-TO基因是2型糖尿病的易感基因，FTO基因变异与肥胖和糖尿病的发病风险相关联。

简介：WehaveexploitedagreenapproachtopreparelayeredtitanateNa2-xHxTi2O5·H2OnanosheetarraysonFTOsubstratebyhydrothermalhydrolysisoftitanium(IV)isopropoxide(TTIP)withaidsofNa2EDTAandTEOAasco-coordinationagents,whichwerethentreatedbyHNO3toreplaceNa+byH+,followedbyacalcinationat450℃totopotacticallytransformintoanataseTiO2nanosheetarrays.SEM,TEM,XRD,andRamanspectroscopyhavebeenemployedtocharacterizethenanosheetfilms.TheTiO2nanosheetarrayswerefurtherappliedaselectrontransportmaterialsofCH3NH3PbI3perovskitesolarcells,achievingpowerconversionefficiencyof6.99%.

简介：含FTO的闪光照相系统中，FTO是由一组同心球层组成的静态高密度客体，其动态量程高达4480。后锥的使用会大大降低系统的直散比DSR，并且散射空间分布的不均匀性也很严重。

简介：摘要:目前，由于我国专利侵权诉讼发生率较高，专利诉讼范围和投诉数量不断增加，将成为更多外国和国内中小企业在企业进入内部市场之前实施定向自由经营（“FTO”）的目标。为了帮助准备在中国开展反侵权研究的律师事务所或公司，进一步了解中国专利回收和反侵权分析的新特点，本文针从自由实施法(FTO)的调查报告与中国专利侵害惩罚性索赔的二个方面加以介绍,希望能为相关人员提供一些参考。

简介：摘要:目前，由于我国专利侵权诉讼发生率较高，专利诉讼范围和投诉数量不断增加，将成为更多外国和国内中小企业在企业进入内部市场之前实施定向自由经营（“FTO”）的目标。为了帮助准备在中国开展反侵权研究的律师事务所或公司，进一步了解中国专利回收和反侵权分析的新特点，本文针从自由实施法(FTO)的调查报告与中国专利侵害惩罚性索赔的二个方面加以介绍,希望能为相关人员提供一些参考。

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简介：AbstractBackground:The hypocaloric diets improve glycemic status in obese individuals, but the response to hypocaloric diets in fat mass and obesity-associated gene (FTO)-rs9939609 gene variant is unknown. This systematic review and meta-analysis aimed to assess the gene-diet interaction of FTO-rs9939609 gene variant and hypocaloric diets on glycemic control in overweight and obese adults.Methods:Cochrane Central Register of Controlled Trials, PubMed, ISI Web of Science, Embase, Scopus, and Google scholar were searched up to December 2018, for relevant clinical trials. Mean changes in fasting blood sugar (FBS), serum insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) were extracted.Results:The pooled analysis of nine studies showed that there was no significant difference between AA/AT and TT genotypes in FBS (weighted mean difference [WMD] = 0.01, 95% confidence interval [CI]: -1.08, 1.10, P = 0.984) and serum insulin (WMD = 0.20, 95% CI: -0.85, 1.26; P = 0.707) after intervention hypocaloric diets. The overweight/obese participants in AA/AT group showed the greatest reduction in HOMA-IR compared with TT genotype following intervention, and this difference was not statistically significant (WMD = -0.38, 95% CI: -0.94, 0.16, P = 0.167).Conclusion:This meta-analysis suggests that there was no significant difference between AA/AT and TT genotypes of FTO-rs9939609 on FBS, serum insulin level, and insulin resistance in response to hypocaloric diets.

简介：Temperature-dependentphotoluminescencecharacteristicsoforganic-inorganichalideperovskiteCH3NH3PbI3-xClxfilmspreparedusingatwo-stepmethodonZnO/FTOsubstrateswereinvestigated.Surfacemorphologyandabsorptioncharacteristicsofthefilmswerealsostudied.Scanningelectronmicroscopyrevealedlargecrystalsandsubstratecoverage.Theorthorhombic-to-tetragonalphasetransitiontemperaturewas140K.Thefilms’excitonbindingenergywas77.6±10.9meVandtheenergyofopticalphononswas38.8±2.5meV.TheseresultssuggestthatperovskiteCH3NH3PbI3-xClxfilmshaveexcellentoptoelectroniccharacteristicswhichfurthersuggeststheirpotentialusageinperovskitebasedoptoelectronicdevices.