简介：Polymer/metalcompositesegmentalJanusnanoparticles(NPs)aresynthesizedbysequentialgrowthagainstpoly(4-vinylpyridine)(P4VP)crosslinkedcP4VP-PSJanusNPs.AJanusclusterofpoly(4-vinylpyridine)-block-polystyrene(P4VPb-PS)diblockcopolymerisself-organizedafterabsorptionontoasilicapatchysphereviahydrogenbonding.SelectivecrosslinkingofP4VPleadstotheformationofrobustcP4VP-PSJanusNPs.WithinthecP4VPdomain,functionalspeciessuchasmetalsarepreferentiallygrownbyinsitureduction.Otherthiol-cappedpolymers,forexample,thiol-cappedpoly(Nisopropylacrylamide)(PNIPAM-SH),canbeconjugatedontotheoppositesidetoformpolymer/metaltriplesegmentalJanusNPs.ThehyperthermiaeffectofAuNPofPNIPAM-Au@cP4VP-PSbynearinfrared(NIR)irradiationcantriggerafasttransitionfromamphiphilictohydrophobicoftheJanusNPsatlowsurroundingtemperature.De-stabilizationoftheemulsionisNIRtriggeredalthoughthesystemtemperatureisbelowLCST(~32°C).

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简介：白癜风作为皮肤科的常见病,对患者的生活质量有较大影响。目前局部应用糖皮质激素、钙调神经磷酸酶抑制剂和光疗法是治疗白癜风的主要方法,但治疗效果均不理想。最近有研究表明,干扰素（IFN）-γ作为白癜风自身免疫的驱动因素,在其发病过程中起重要作用。因此,抑制IFN-γ或其下游的作用剂如Janus激酶（JAKs）可能是治疗白癜风的有效策略。鲁索利替尼（酪氨酸蛋白激酶抑制剂）作为一种JAK1/2抑制剂,

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简介：Thedevelopmentandplasticityofcentralauditorysystemcanbeinfluencedbythechangeofperipheralneuronalactivity.However,themolecularmechanismparticipatingintheprocessremainselusive.Brain-derivedneurotrophicfactor(BDNF)bindingwithitsfunctionalreceptortropomyosinreceptorkinaseB(TrkB)hasmultipleeffectsonneurons.Hereweusedaratmodelofauditorydeprivationbybilateralcochlearablation,toinvestigatethechangesinexpressionofBDNFandTrkBintheauditorycortexafterauditorydeprivationthatoccurredduringthecriticalperiodforthedevelopmentofcentralauditorysystem.Reversetranscription-quantitativepolymerasechainreaction(RTqPCR)andimmunohistochemistrymethodswereadoptedtodetectthemRNAandproteinexpressionlevelsofBDNFandTrkBintheauditorycortexat2,4,6and8weeksaftersurgery,respectively.ThechangeintheexpressionofBDNFandTrkBmRNAsandproteinsfollowedsimilartrend.Inthebilateralcochlearablationgroups,theBDNF-TrkBexpressionlevelinitiallydecreasedat2weeksbutincreasedat4weeksfollowedbythereductionat6and8weeksaftercochlearremoval,ascomparedtotheage-matchedshamcontrolgroups.Inconclusion,theBDNF-TrkBsignalingisinvolvedintheplasticityofauditorycortexinanactivity-dependentmanner.