简介：CLINICALMATERIALSThepatientwas7year-oldboy,bodyweight20kg.HewasadmittedonMay10th,2002becauseoffever,rashes,enlargedlymphnodes,conjunctivaeinjection,strawberrytongue,edemaanderythemaofthehandsandfeet.Laboratorydataasfollow:1.Prominentincreaseinwhitebloodcell(WBC)14.3-22.7×109.2.Anemia,hemoglobin(Hb)121→103g/L.

简介：Toinvestigatetheroleofnegative-regulatoryfactorsA20,IRF-4andTRAF4ofthetoll-likereceptor(TLR)signalpathwaysinimmunologicalpathogenesisofKawasakidisease(KD),48childrenwithKawasakidisease,16childrenwithinfectiousdisease(ID)and16age-matchedhealthychildrenwerestudied.Reverse-transcriptionPCR(RT-PCR)andreal-timePCRwereusedtoevaluatetheexpres-sionlevelsofnegative-regulatoryandeffectivefactorsintoll-likereceptor4(TLR4)signalpathwaysandproinflammatoryfactorsinperipheralbloodmonocyte/macrophage(MC).Inthisstudy,expressionlevelsofTLR4,MD-2,MyD88,IRAK-4,TRAF6,TAK1,andTAB2mRNAinKDgroupweredetectedtobeelevatedsignificantlyduringacutephaseofKD.Transcriptionlevelsofnegative-regulatoryfactorsA20,IRF-4andTRAF4mRNAinKDorIDpatientsincreasedremarkably.However,expressionsofIRF-4andTRAF4inKDpatientsweredetectedtobelowerthanthatinIDpatients,exceptthattran-scriptionlevelsofA20werefoundtobehigherthanthatinIDpatients.Simultaneously,expressionsofproinflammatorycytokinessuchasL-1β,IL-6andTNF-αinKDpatientsweresignificantlyelevatedcom-paredwiththoseinIDpatients.Furthermore,itwasfoundthatstimulationoflipopolysaccharide(LPS)remarkablyup-regulatedtheexpressionsofnegative-regulatoryfactorsA20,IRF-4andTRAF4inKDpa-tientsorhealthyvolunteers.ThemRNAlevelsofallthethreefactorsinKDpatientswerefoundtobelowerthanthatinthelatter.Inaddition,transcriptionlevelsofIRF-4andTRAF4inKDpatientswithcoronaryarterylesion(KD-CAL~+)weredetectedtobelowerthanthoseinKDpatientswithoutcoronaryarterylesion(KD-CAL~-)duringacutephase,whilethatofA20inKD-CAL~+groupwerelowerthanthatinthelatter.AndthelevelsofexpressionsofproinflammatorycytokinesinKD-CAL~+groupwerefoundtobehigherthanthoseinKD-CAL-group(P<0.01).Thesefindingssuggestthataberrantexpressionofnegative-regulatoryfactorsofTLRssignalpathwaysmaybeinvolved

简介：AbstractChronic obstructive pulmonary disease (COPD) has become the third-leading cause of death worldwide, which is a severe economic burden to the healthcare system. Chronic bronchitis is the most common condition that contributes to COPD, both locally and systemically. Neutrophilic inflammation predominates in the COPD airway wall and lumen. Logically, repression of neutrophilia is an essential fashion to COPD treatment. However, currently available anti-neutrophilic therapies provide little benefit in COPD patients and may have serious side effects. Thus, there is an urgent need to explore an effective and safe anti-neutrophilic approach that might delay progression of the disease. Sialic acid-binding immunoglobulin-like lectin (Siglec)-9 is a member of the Siglec cell surface immunoglobulin family. It is noteworthy that Siglec-9 is highly expressed on human neutrophils and monocytes. Ligation of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human neutrophils. Furthermore, administration of antibody to Siglec-E, mouse functional ortholog of Siglec-9, restrained recruitment and activation of neutrophils in mouse models of airway inflammation in vivo. Given the critical role that neutrophils play in chronic bronchitis and emphysema, targeting Siglec-9 could be beneficial for the treatment of COPD, asthma, fibrosis, and related chronic inflammatory lung diseases.

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简介：美国老牌机车杂志《摩托车驾驶员》（Motorcyclis）将Versys推选为年度摩托车（MOTORCYCLEOFTHEYEAR）的理由是：Versys到底是什么？答案是：所有摩托车。你可以把它当作通勤代步的街车，公路摩托车，越野摩托车，旅行摩托车——随便你怎么定位。

简介：春日阳光下，驾驭这头温柔猛兽，欢快轻柔地跳跃在落日的地平线上，耳边响起BONJOV1的It’sMyLife那首歌，穿过地平线闪过时间的屏障回到了15年前。黑夜中视线穿过地平线，似快又慢地迎来晨幕，迎着晨风中青草与雾气的味道，骑着我爱的摩托车，身后竖起飘荡的身影，随意切割着光线的布撒，一刻不停息地驶向天际，消失在地平线之下，将我的神经接在公路上……

简介：Z750R将新潮时髦的造型和体贴柔顺的操控性能融为一体，以“外冷内热”的性格获得了很多骑手的青睐，2011年新问世的Z750R，不仅仅是在Z750后面增加一个“R”字母，

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简介：上一期中，我们介绍了Lucy的家人，你还记得吗？今天，来认识一下Lucy在学校的英语老师和Mary的法语老师!Mary是谁？去文中找找看!

简介：我喜欢春天，因为我喜欢暖暖的风。我喜欢夏天，因为我喜欢冰激凌。我喜欢秋天，因为我喜欢新鲜的苹果。我喜欢冬天，因为我喜欢堆雪人。

简介：“wouldlike”和“feellike”都有“想要”之意，但它们的含义和用法又有不同，下面谈谈它们的差异。

简介：川崎面向欧洲市场推出的运动旅行摩托车1400GTR，搭载了内置可变气门正时系统（VVT）、排量高达1352ml的直列四缸发动机有着令人窒息的动力性能，悠长的耐力和遒劲的扭矩让万水千山变为咫尺之间；全新一代的铝合金单体车架、强韧坚固的悬挂系统，赋予整备质量超过300kg的庞然大物矫健的身手，如同巨汉踩着节拍在山间弯道上弦歌而舞；

简介：Ltmedisease(Lymeborreliosis)iscausedbythetick-bornespiro-elraeteBorreliaburgdooCeri.Erythemamigrans,anearlyskinlesion,isthemostcommonclinicalpresentation.Theorganismmayspread,causingvariouslatermanifestations.

简介：春季是传染性疾病的高发时段，预防工作一定要做到及时、有效。也许从下面的短文中我们可以得到一些启示！

简介：Yearsonthescene,musicianandpromoterJonCampbellhaslearnedwhatChina'smusicfanswanttohear-andpayfor.

简介：DongWenguangwasagrandsonofDongHe.HewasbornatthebeginningoftheNorthernSongDynasty.Theemperoradvocatdeforcultureandlaunchedimperialexaminations.DongWenguangwasfar-sightde.Hebegantorunschools.Helaiddownstrictfamilyrules,tellingthesonsanddaughtersofthefamilytoreadbooks.

简介：Ilovepotatoes.Potatoesareverydelicious.Therearemanywaystocookpotatoes,suchasmashedpotatoes,Frenchfries,potatosalad.AndIlikeFrenchfriesbest,it’smyfavoritesnack.Besides,potatoesarefullofnutrition.Weshouldeatmorepotatoes.Trythem,Ithinkyou’lllikethem.(指导老师:钱莹)

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