简介：目的：观察针药并用治疗非特异性急性腰扭伤的临床疗效。方法：将69例患者按就诊川页序随机分为针药并用组、针刺组和药物组。针刺组24例，采用针刺治疗，每日1次，共治疗5次；药物组20例，采用口服双氯芬酸钠治疗，50mg每次，每日2次，连服5日；针药并用纽25例采用与针刺组、药物组相同的针刺和药物治疗。以疼痛量表和下腰痛量表评价临床疗效。结果：三组患者治疗后在疼痛，活动度方面均有一定改善，但针药并用组疗效最佳，与针刺组、药物组比较，差异有统计学意义（P〈0．01）；针刺组与药物组比较，差异无统计学意义。结论：针药并用治疗急性腰扭伤疗效优于单纯针刺治疗或常规剂量双氯芬酸钠治疗。

简介：植物非特定的类脂化合物转移蛋白质(nsLtps)被报导了对细菌、真菌的病原体涉及植物防卫活动。在这研究，我们识别了135(122通常认为并且13以前识别了)SolanaceaensLtps，它被聚类进8个不同的组。由与Boutrot的nsLtp分类作比较，我们分类这八个组进五种类型(我，II，IV，IX和X)。我们把SolanaceaensLtps与Arabi-dopsis和GramineaensLtps作比较并且发现(1)那打字我，II和IV被Solanaceae，Gramineae和Arabidopsis分享；(2)类型III，V，VI和VIII被Gramineae和Arabidopsis分享然而并非到目前为止在Solanaceae检测了；(3)而类型IX在Arabidopsis和Solanaceae仅仅是在场的，类型VII仅仅在Gramineae被发现；(4)类型X是在我们的数据说明52.59%SolanaceaensLtps的一种新类型，并且到目前为止没在任何另外的植物被报导。我们进一步造了并且比较了八个组的三维的结构，并且发现在nsLtp家庭以内的主要功能的多样化能被早于到monocot/dicot分叉，并且许多基因复制和顺序变化在monocot/dicot分叉以后发生在nsLtp家庭，特别在Solanaceae。

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简介：Seacucumbers,ApostichopusjaponicusSelenka,werefeddietscontainingnon-immunostimulant(basaldiet),0.2%β-glucanand0.02%glycyrrhizininarecirculatorywatersystemfor45days,andsubsequentlychallengedwithVibriosplendidusbyinjectionat1.0×108cfu/seacucumberfor15days.Phagocyticcapacity(PC),intracellularsuperoxideanionproduction(ISAP),ly-sozyme(LSZ)activityandsuperoxidedismutase(SOD)activityinthecoelomicfluidwereanalyzedonthe0th,5th,10thand15thdaysafterinjection.Resultsshowedthatafterthe45-dayfeedingperiod,PC,ISAP,LSZactivityandSODactivityinseacucumbersfedwithdietaryβ-glucanorglycyrrhizinweresignificantlyhigherthaninthosefedwiththebasaldiet.Onthe5thdayafterinfection,alltheimmuneparametersexaminedintheseacucumbersinjectedwithV.splendidusdecreasedinvaluesignificantly.Onthe15thday,PC,ISAPandLSZactivityreturnedtolevelssimilartothoseonthe0thday.Fortheseacucumbersinjectedwithsaline,therewerenosignificantdifferencesinalltheimmuneparametersexaminedandinthecumulativemorbidityduringthe15-daychallengingtrial.AfterinjectingwithV.splendidus,thecumulativemorbidityofseacucumbersfedwiththebasaldietwassignificantlyhigherthanthosefedwithdietaryβ-glucanorglycyrrhizinwhenchallengedwithV.splendiduschallengedseacucumberfedwiththebasaldietwassignificantlyhigherthanthosefedwithdietaryβ-glucanorglycyrrhizin.Therewasnosignificantdifferenceincumulativemorbiditybetweenthedietaryβ-glucanandglycyrrhizintreatmentsovertime.

简介：AbstractNon-alcoholic fatty liver disease (NAFLD) is a disorder of lipid metabolism. The lipotoxic intermediates of lipid metabolism cause mitochondrial dysfunction and endoplasmic reticulum stress. Organelle-specific autophagy is responsible for the removal of dysfunctional organelles to maintain intracellular homeostasis. Lipophagy contributes to lipid turnover by degrading lipid droplets. The level of autophagy changes during the course of NAFLD, and the activation of hepatocyte autophagy might represent a method of treating NAFLD.

简介：Since1990s,secondlanguagelearningmotivationresearchpresenteddiversifieddevelopmenttendencyinChina,particularlyanempiricalstudyisontherise,whichverifiedthevalidationofforeignlanguagelearningmotivationtheories,andnewdiscoveriesaremade.Inrecentyears,astheInternationalcommunicationandcooperationincreasing,learningEnglishisbecomingthebasicdemandoftalentsin21stcentury.While,toagreatextent,learningEnglishiscloselyrelatedtothelearningmotivation,whenlearnerspositivelywanttolearnandmakebestuseofreasonablemethods,theycangetapprovingresults.Therefore,thisessaywilldiscussmotivationinEnglishforspecificlearning.

简介：AbstractBackground:Response to immune checkpoint inhibitors (ICIs) is affected by multiple factors. This study aimed to explore whether sites of metastasis are associated with clinical outcomes of ICIs in advanced non-small-cell lung cancer (NSCLC) patients.Methods:The data of NSCLC patients with high programmed death-ligand 1 expression and good performance status receiving first-line ICIs monotherapy from Guangdong Provincial People’s Hospital between May 2019 and July 2020 were retrospectively analyzed. Metastatic sites included liver, bone, brain, adrenal gland, pleura, and contralateral lung. Progression-free survival (PFS) and overall survival (OS) were compared between different metastatic sites and metastatic burden by the Kaplan-Meier method. Organ-specific disease control rate (OSDCR) of different individual metastatic sites was evaluated.Results:Forty NSCLC patients meeting the criteria were identified. The presence of liver metastasis was significantly associated with shorter PFS (3.1 vs. 15.5 months, P = 0.0005) and OS (11.1 months vs. not reached, P = 0.0016). Besides, patients with bone metastasis tend to get shorter PFS (4.2 vs. 15.5 months, P = 0.0532) rather than OS (P = 0.6086). Moreover, the application of local treatment could numerically prolong PFS in patients with brain metastasis (15.5 vs. 4.3 months, P = 0.1894). More metastatic organs involved were associated with inferior PFS (P = 0.0052) but not OS (P = 0.0791). The presence of liver metastasis or bone metastasis was associated with more metastatic organs (Phi[φ]: 0.516, P = 0.001). The highest OSDCR was observed in lung (15/17), and the lowest in the liver (1/4).Conclusions:Metastases in different anatomical locations may be associated with different clinical outcomes and local tumor response to ICIs in NSCLC. ICIs monotherapy shows limited efficacy in patients with liver and bone metastasis, thus patients with this type of metastasis might require more aggressive combination strategies.

简介：我们在中国人调查了前列腺特定的抗原(PSA)和PSA密度(PSAD)的表演特征。经历了transrectal的所有中国人到2013的从2000年的指导超声的前列腺活体检视(TRUS-PB)被包括。为PSA和PSAD操作特征(巨鸟)曲线的接收装置被分析。敏感，特性，积极预兆的价值(PPV)和在不同截止层次的否定预兆的价值(NPV)是计算的。2606个中国人的一个总数被包括。为ROC，在曲线下面的区域为PSA是0.770(P<；0.001)并且0.823为PSAD(P<；0.001)。4.5ngml−1的PSA94.4%的有的敏感，14.1%的特性，29.5%的PPV，和86.9%的NPV；0.12ngml−1cc−1的PSAD有94.5%的敏感，26.6%的特性，32.8%的PPV，和92.7%的NPV。在逻辑回归分析的multivariate上，在4.5ngml−1截止的PSA(或1.61，95%CI1.05-2.45，P=0.029)并且在0.12ngml−1cc截止的PSAD−1(或6.22，95%CI4.20-9.22，P<；0.001)是为TRUS-PB上的前列腺癌症察觉的重要预言者。在结论，在在中国人的不同截止层次的PSA和PSAD的表演与在白种人的那些很不同。4.5ngml−1的PSA和0.12ngml−1cc−1的PSAD在95%敏感附近有并且是在中国人的前列腺癌症察觉的重要预言者。

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简介：TheteachingofEnglishforSpecificPurposeshasbeeninexistenceforover30years,andhasbeenprominenceformorethan20years,andisstillintheascendant.ESPteachingaccountsforaconsider-ableproportionoftheteachingofEnglishasaforeignlanguageinChina.ItisthereforenecessaryforusChineseteacherstoknowmoreaboutESP.

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简介：1PURPOSOFTHESTUDYThearticle99intheSpecificRulesforEnforcingtheFrontierHealthandQuarantineLawofthePeople’sRepublicofChinahasindicatedthatthehealthandquarantineorganizationshallpreventanyforeignersufferingfromvenerealdiseasesfromenteringtheterritory.Becausetheroutineconfirmatorytestforsyphilisfluorescenttreponemalantibodyab-

简介：Arithmeticcodingisarelativelynewloss-lessdatacompressiontechniquethathasattractedmuchattentioninrecentyears.Weshowtheiterationofbit-levelarithmeticcodingcanbespecifiedbyacontinuousfunction.Theanalysisexpressionandsomepropertiesofthisfunctionarediscussed.Anapplicationofthefunctionisprovidedforexploringthesecurityofarithmeticcodeswhentheyareusedfordataencryption.

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简介：Thispaperaimsatdevelopingastochastic-elasticmodelofasoftelasticbodyadheringonawavysurfaceviaapatchofmolecularbonds.Theelasticdeformationofthesystemismodeledbyusingcontinuumcontactmechanics,whilethestochasticbehaviorofadhesivebondsismodeledbyusingBell'stypeofexponentialbondassociation/dissociationrates.Itisfoundthatforsufficientlysmalladhesionpatchsizeorstressconcentrationindex,theadhesionstrengthisinsensitivetothewavelengthbutdecreaseswiththeamplitudeofsurfaceundulation,andthatforlargeadhesionpatchsizeorstressconcentrationindex,thereexistoptimalvaluesofthesurfacewavelengthandamplitudeformaximumadhesionstrength.

简介：AbstractFor the detection of steatosis, quantitative ultrasound imaging techniques have achieved great progress in past years. Magnetic resonance imaging proton density fat fraction is currently the most accurate test to detect hepatic steatosis. Some blood biomarkers correlate with non-alcoholic steatohepatitis, but the accuracy is modest. Regarding liver fibrosis, liver stiffness measurement by transient elastography (TE) has high accuracy and is widely used across the world. Magnetic resonance elastography is marginally better than TE but is limited by its cost and availability. Several blood biomarkers of fibrosis have been used in clinical trials and hold promise for selecting patients for treatment and monitoring treatment response. This article reviews new developments in the non-invasive assessment of non-alcoholic fatty liver disease (NAFLD). Accumulating evidence suggests that various non-invasive tests can be used to diagnose NAFLD, assess its severity, and predict the prognosis. Further studies are needed to determine the role of the tests as monitoring tools. We cannot overemphasize the importance of context in selecting appropriate tests.

简介：Thispaperinvestigatesthemathematicfeaturesofnon-linearmodelsanddiscussestheprocessingwayofnon-linearfactorswhichcontributestothenon-linearityofanonlinearmodel.Onthebasisoftheerrordefinition,thispaperputsforwardanewadjustmentcriterion,SGPE.Last,thispaperinvestigatesthesolutionofanon-linearregressionmodelinthenon-linearmodelspaceandmakesthecomparisonbetweentheestimatedvaluesinnon-linearmodelspaceandthoseinlinearmodelspace.