简介：Regimeswitching,whichisdescribedbyaMarkovchain,isintroducedinaMarkovcopulamodel.Weprovethatthemarginals(X,H~i),i=1,2,3oftheMarkovcopulamodel(X,H)arestillMarkovprocessesandhavemartingaleproperty.Inthisproposedmodel,apricingformulaofcreditdefaultswap(CDS)withbilateralcounterpartyriskisderived.更多还原

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简介：Sonodynamictherapy(SDT)isanemergingapproachthatinvolvesacombinationoflow-intensityultrasoundandspecializedchemicalagentsknownassonosensitizers.Ultrasoundcanpenetratedeeplyintotissuesandcanbefocusedintoasmallregionofatumortoactivateasonosensitizerwhichoffersthepossibilityofnon-invasivelyeradicatingsolidtumorsinasite-directedmanner.Inthisarticle,wecriticallyreviewedthecurrentlyacceptedmechanismsofsonodynamicactionandsummarizedtheclassificationofsonosensitizers.Atthesametime,thebreathofevidencefromSDT-basedstudiessuggeststhatSDTispromisingforcancertreatment.

简介：Recentfindingsinthepathophysiologyandmonitoringofhemostasisinpatientswithendstageliverdiseasehavemajorimpactoncoagulationmanagementduringlivertransplantation.Thereisincreasingevidence,thatthechangesinbothcoagulationfactorsandplateletcountregularlyobservedinpatientswithlivercirrhosiscannotbeinterpretedasareliableindicatorofdiffusebleedingrisk.Instead,adifferentiatedviewonhemostasishasledtotheconceptofarebalancedcoagulationsystemWhileitisimportanttorecognizethatprocoagulantfactorsarereducedinlivercirrhosis,itisalsoevidentthatsynthesisofanticoagulantfactorsandfibrinolyticproteinsproducedintheliverisalsodiminished.Similarly,thedecreasedplateletcountmaybecounterbalancedbyincreasedplateletaggregabilitycausedbyhighlyactivevonWillebrandmultimeres.Thecoagulationsystemisthereforstatedtoberebalanced.Whileundernormal＂unstressed＂conditionsdiffusebleedingisrarelyobserved,howeverbothdiffusebleedingorthrombusformationmayoccurwhencompensationmechanismsareexhausted.Whilemostpatientspresentingforlivertransplantationhaveseverecirrhosis,liverfunctionandthusproductionofpro-andanticoagulantfactorscanbepreservedespeciallyincholestaticliverdisease.Duringlivertransplantation,profoundchangesinthehemostasissystemcanoccur.Surgicalbleedingcanleadtodiffusebleedingascoagulationfactorsandplateletsarealreadyreduced.Ischemiaandtissuetraumacanleadtoalterationsofhemostasiscomparabletotraumainducedcoagulopathy.Afurthercommondisturbanceoftenstartingwiththereperfusionofthetransplantedorganishyperfibrinolysiswhichcaneventuallyprecipitatecompleteconsumptionoffibrinogenandanendogenousheparinizationbyglycocalyxshedding.Moreover,thromboticeventsinlivertransplantationsarenotuncommonandcontributetoincreasedmortality.Besidesconventionallaboratorymethods,bed-sidemonitoringofhemostasis（e.g.,thrombelastography,thrombe

简介：连续统wavepacket干扰被数字地解决时间依赖者Schr调查?为有激光地的氢原子的相互作用的dinger方程。获得的wavepacket进化显示那，在over-the-barrier电离政体(1016W/cm2),电离的continuumcontinuum(CC)干扰电子在highorder泛音产生(HHG)成为主要过程，与连续统界限(CB)相比转移，由Kohler等报导了。[Phys。加快。Lett。105(20)，203902(2010)].We为控制电离的量轨道建议一个二颜色的激光地计划电子并且为扩大CC泛音精力。作为结果，一个高精力平台发生在HHG光谱，它完全从CC泛音发源，与由二颜色的域的相对阶段可调节的截止。这在超级强烈激光地里提供原子和分子的动态特征的进一步的理解并且提供一个机会想象原子或分子的潜力。

简介：Magdalena河有最大的长度(1612km)和排水区域(在哥伦比亚的任何河系统的257400km2)，和它的分水岭占据24%哥伦比亚的领土。河在加勒比海海(BocasdeCenizas)在3685m和流动的举起在Andes山脉的山脉发源到它的嘴。为这研究，每日的流动分泌物(Q)的信息，推迟的沉积运输(Qs)和平均数推迟了沉积集中(C从为Magdalena河的1990-2010的s)基于在计量车站(到嘴的最靠近的车站)的Calamar的大小，被水文学，气象学和哥伦比亚(用西班牙语的IDEAM)的环境研究的研究所提供。吝啬的年度推迟的沉积负担是169?踋???跱???????????迱??????x

简介：Theeffectofportalveintumorthrombus(PVTT)ontheprognosisofpatientswithhepatocellularcarcinomahasbecomeclearoverthepastseveraldecades.However,identifyingthemechanismsandperformingthediagnosisandtreatmentofPVTTremainchallenging.Therefore,thisstudyaimedtosummarizetheprogressintheseareas.AcomputerizedliteraturesearchinMedlineandEMBASEwasperformedwiththefollowingcombinationsofsearchterms:'hepatocellularcarcinoma'AND'portalveintumorthrombus.'AlthoughseveralsignaltransductionormolecularpathwaysrelatedtoPVTThavebeenidentified,theexactmechanismsofPVTTarestilllargelyunknown.Manybiomarkershavebeenreportedtodetectmicrovascularinvasion,butnonehaveprovedtobeclinicallyusefulbecauseoftheirlowaccuracyrates.SorafenibistheonlyrecommendedtherapeuticstrategyinWesterncountries.However,moretreatmentoptionsarerecommendedinEasterncountries,includingsurgery,radiotherapy(RT),transhepaticarterialchemoembolization(TACE),transarterialradioembolization(TARE),andsorafenib.Therefore,weestablishedastagingsystembasedontheextentofportalveininvasion.Ourstagingsystemeffectivelypredictsthelong-termsurvivalofPVTTpatients.Currently,severalclinicaltrialshadshownthatsurgeryiseffectiveandsafeinsomePVTTpatients.RT,TARE,andTACEcanalsobeperformedsafelyinpatientswithgoodliverfunction.However,onlyafewcomparativeclinicaltrialshadcomparedtheeffectivenessofthesetreatments.Therefore,morerandomizedcontrolledtrialsexaminingtheextentofPVTTshouldbeconductedinthefuture.

简介：Currentlytheclinicalmanagementofbreastcancerreliesonrelativelyfewprognostic/predictiveclinicalmarkers(estrogenreceptor,progesteronereceptor,HER2),basedonprimarytumorbiology.Circulatingbiomarkers,suchascirculatingtumorDNA(ctDNA)orcirculatingtumorcells(CTCs)mayenhanceourtreatmentoptionsbyfocusingontheverycellsthatarethedirectprecursorsofdistantmetastaticdisease,andprobablyinherentlydifferentthantheprimarytumor'sbiology.Toshiftthecurrentclinicalparadigm,assessingtumorbiologyinrealtimebymolecularlyprofilingCTCsorctDNAmayservetodiscovertherapeutictargets,detectminimalresidualdiseaseandpredictresponsetotreatment.Thisreviewservestoelucidatethedetection,characterization,andclinicalapplicationofCTCsandctDNAwiththegoalofprecisiontreatmentofbreastcancer.

简介：联系精索静脉曲张的男不孕古典主义地用外科被管理了或帮助了繁殖技术。与在联系精索静脉曲张的不孕作为一个pathophysiological因素增加氧化应力的证据，医药治疗特别抗氧化剂可能与更低的风险成为一种治疗选择。我们在归因于精索静脉曲张的男不孕的管理在各种各样的医药代理人的角色上考察了存在文学。医药治疗典型地与外科对药治疗作为辅助治疗与安慰剂，药对手术的(b)比较，和药的(c)比较处于象二药或一药的(a)比较那样的三种不同状况被评估独自一个。由于数据的异质和进行得好的研究的缺乏，有不够的数据与联系精索静脉曲张的不孕为人推荐医药治疗的平淡的使用，外科仍然是选择的处理。怀孕和实时出生率通常没在精子参数在大多数研究和仅仅的改进被报导或抗氧化剂能力是不够的支持它的平淡的使用。抗氧化剂治疗由于它的理论利益，从现出症状之前的潜的研究的数据，和主要副作用的缺乏是一种潜在的选择。有在精索静脉曲张的外科的修理以后的抗氧化剂的辅助治疗可以改进结果并且是为进一步的研究的一个潜在的区域。

简介：Objective:Toexploretheclinicopathologicalfeatures,surgicaltreatmenttechniques,andprognosticriskfactorsofintrahepaticcholangiocarcinoma(ICC).Methods:Atotalof104ICCcaseswerecollectedfromJanuary2008toDecember2013atTianjinMedicalUniversityCancerInstituteandHospitalanddividedintothehepatichilumlymphadenectomy(HLL,21cases),extendedhepatichilumlymphadenectomy(EHLL,12cases),andnon-lymphadenectomy(NL,71cases)groups.Theclinicaldataofthepatientswereretrospectivelyanalyzed,andtheprognosticdifferenceswerecomparedamongdifferentgroups.Results:The1-,2-,and3-yearoverallsurvival(OS)ratesofallcaseswere72.1%,56.1%,and43.7%,respectively.Themediansurvivaldurationwas34months.The1-,2-,and3-yearOSratesoftheHLLgroup(42.9%,28.6%,and28.6%,respectively)weresignificantlylowerthanthoseoftheNLgroup(78.9%,62.5%,and47.8%,respectively).Meanwhile,the1-,2-,and3-yearOSratesoftheEHLLgroup(75.0%,56.1%,and33.3%,respectively)werenotsignificantlydifferentfromthoseoftheothertwogroups.Univariateanalysisshowedthatage,gender,AmericanJointCommitteeonCancer(AJCC)stage,differentiation,ferritin(Fer),carbohydrateantigen19-9(CA19-9)andcarcinoembryonicantigen(CEA)levels,lymphnodemetastasis(LNM),andlymphnodedissection(LND)wereprognosticfactorsforthelong-termsurvivalofICC.Meanwhile,multivariateanalysisrevealedthatage,AJCCstage,differentiation,Ferlevels,andLNMwereindependentriskfactorsforsurvival.Conclusions:ICCpatientswillnotbenefitfromlymphadenectomyintheabsenceofLNM.However,systematiclymphadenectomymayimproveICCoutcomesifthelocationoflymphaticmetastasisisknown.Age,AJCCstage,differentiation,Ferlevel,andLNMareindependentriskfactorsforsurvivalinICC.

简介：Thisstudyexploredtheeffectsofcoldplasmatreatmentonseedgermination,plantgrowth,andpeanutyield.Coldplasmatreatmentimprovedgerminationandseedlinggrowth,andthe120Wtreatmentproducedthebesteffect.Germinationpotentialandgerminationrateweremarkedlyraisedby150%and21%,respectively.Germinationwasacceleratedandtheuniformityofemergenceimproved.Theapparentcontactanglewasdecreasedby53%.Seedlingshootandrootdryweightsincreasedby11%and9%.Leafarea,leafthickness,leafnitrogenconcentration,chlorophyllcontents,anddryweightatthefruitingstage,togetherwithplantheight,stemdiameter,androotdryweightatthematurestagewereallmarkedlyraisedbythecoldplasmatreatment.Thecoldplasmatreatmentenhancedyieldcomponents,suchasbranchnumbersperplant,podnumbersperplant,and100podweightsby8%,13%,and9%,respectively,comparedtothecontrol.Furthermore,theyieldimprovedby10%.Theseresultssuggestedthatcoldplasmatreatmentimprovedgermination,plantgrowth,andyield,whichmightbeduetothecoldplasmaincreasingtheleafarea,nitrogenconcentrations,andchlorophyllcontents.

简介：BackgroundDeepsternawoundinfection(DSWI)aftermediansternotomyforcardiacsurgeryisoneofthemostcomplexandpotentiallylife-threateningcomplications.ItsverydifficulttotreatDSWI,andthereislackofagreementregardingthebesttherapystrategy.Thus,weaimedtosummarizeourexperiencesofsurgicaltreatmentforDSWI,inwhichsatisfactoryclinicalresultswereobtained.MethodsWeretrospectivelyanalyzed17caseswhosufferedfromDSWIaftercardiacsurgeryinourdepartmentfromJanuary2010toJune2015.Therewere8maleand9femalepatientswiththeiraverageageof62.7±9.5years(range42~75years).Allpatientsreceivedreservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflaps.ResultsTheaverageintervalbetweencardiacsurgeryanddiagnosedDSWIwas10.9±6.5days(range5~21days).Timeofvacuum-assistedsuctiondrainagewas11.6±4.8days(range5~15days)andwoundhealingtimewas27.3±7.2days(range23~35days).Allpatientshadanuneventfulpostoperativerecoveryandgoodwoundhealing.Follow-uptimewas33.7±13.3months(range8~74months).Norecurrentinfectionwasobserved.ConclusionsReservationofpartofsternumcombinedwithvacuum-assistedsuctiondrainageandbilateralpectoralismajormyocutaneousadvancementflapsisasimpleandeffectivesurgicalstrategyforthetreatmentofDSWIaftercardiacsurgery.

简介：Cancertreatmentfailure,drugresistance,ormetastaticrecurrencearethoughttobecausedmainlybytheexistenceofaverysmallnumberofcancerstemcells(CSCs).Thecharacteristicsofthissubgroupofcellsincludeself-renewal,tumorigenesis,multipledifferentiationandhighinvasiveness,metastasis,anddrugresistancepotential.ManystudieshavedemonstratedthatCSCsplayimportantrolesintumorgrowth,spreadandmetastaticrelapseaftertreatment,andarecloselyrelatedtotheprognosisofpatients.Fromatherapeuticviewpoint,deepinsightsintotheCSCsbiology,developmentofspecifictherapeuticstrategiesfortargetingCSCs,andcharacterizationoftheirmicroenvironmentcouldbeanidealwaytocombatcancer.

简介：Alightpurplishredsapphireisheattreatedinanairtightcrucible.Thesamplechangeslittleincolorafterreceivingheattreatmentat1100°C,butturnstolightblueandblueafterbeingtreatedat1200°Cand1300°C,respectively.Beforeheating,theUV-VISabsorptionspectraofthesamplearedominatedbythe551nmbroadabsorptionbandcontributedbythed-electrontransition~4A_2→~4T_2ofCr~(3+).Afterheating,theUV-VISabsorptionspectraaredominatedbythe563nmbroadabsorptionbandcontributedbytheintervalencechargetransferofFe~(2+)-Ti~(4+).ThexrayphotoelectronspectroscopytestrevealsthattheFe~(2+)andTi~(4+)ioncontentsincreasewithincreasingtemperature.ThesapphirechangingfromlightpurplishredtoblueintheheatingprocessisowingtothefactthattheFe~(2+)andTi~(4+)contentsgrowandtheintervalencechargetransferofFe~(2+)-Ti~(4+)selectivelyabsorbsUV-VISlight.

简介：Therecognitionthatpsychosocialriskfactorscontributetothepathogenesisofcardiovasculardiseasehasledtothedevelopmentofanewfieldofbehavioralcardiology.Theinitialimpetusforthisfieldwasstudiesperformedinthe1980sand1990sthatprovidedepidemiologicalevidenceandapathophysiologicalbasisforastronglinkbetweenanumberofpsychosocialriskfactorsandcardiovasculardisease,includingdepression,anxiety,hostility,jobstress,andpoorsocialsupport.Inrecentyears,additionalpsychosocialriskfactorshavebeenidentified,includingpessimism;otherformsofchronicstress,suchaschildhoodabuseandtrauma,andthepsychologicalstressthatmaybeassociatedwithchronicmedicalillness;lackoflifepurpose;andthesyndromeof“vitalexhaustion,”whichconsistsofatriadofexhaustion,demoralization,andirritability.Newresearchinthelastdecadehasalsoestablishedthatpositivepsychosocialfactors,suchasoptimism,positiveemotions,avibrantsociallife,andastrongsenseoflifepurpose,canhaveanimportanthealth-bufferingeffectthroughtheirfavorableinfluenceonhealthbehaviorsandpromotionofpositivephysiologicalfunctioning.Patientscanbescreenedforpsychosocialriskfactorsinclinicalpracticethrougheithertheuseofopen-endedquestions,whichcanbeintegratedintoaphysician’sstandardreviewofsystems,ortheuseofshortquestionnaires.Physicianscanassistinthetreatmentofpsychosocialriskfactorsinvariousways,suchasscreeningpatientsforpsychologicaldistressandmakingappropriatereferralswhenindicated,providingpatientswithpracticallifestylesuggestions,andemployingofficepersonneltoteachpatientsbehavioralorpsychosocialinterventionsthatcanpromoteasenseofwell-beingand/orreducestress.

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简介：Thermalplasmawasappliedforthetreatmentofcokewastewatersludgederivedfromthesteelindustryinordertoinvestigatethefeasibilityofthesafetreatmentandenergyrecoveryofthesludge.A30kWplasmatorchsystemwasappliedtostudythevitrificationandgasproductionofcokewastewatersludge.Toxicityleachingresultsindicatedthatthesludgetreatedviathethermalplasmaprocessconvertedintoavitrifiedslagwhichresistedtheleachingofheavymetals.CO2wasutilizedasworkinggastostudytheproductionandheatenergyofthesyngas.Theheatingvalueofthegasproductsbythermalplasmaachieved8.43kJ/L,indicatingthefurtherutilizationofthegasproducts.Consideringtheutilizationofthesyngasandrecoveryheatfromthegasproducts,theestimatedtreatmentcostofcokewastewatersludgeviaplasmatorchwasabout0.98CNY/kgsludgeintheexperiment.Bypreliminaryeconomicanalysis,thedehydrationcosttakesanimportantpartofthetotalsludgetreatmentcost.Thetreatmentcostofthecokewastewatersludgewith50wt.%moisturewascalculatedtobeabout1.45CNY/kgsludgedrybasis.Thetreatmentcostofthecokewastewatersludgecouldbeeffectivelycontrolledbydecreasingthewatercontentofthesludge.Thesefindingssuggestthataneconomicdewateringpretreatmentmethodcouldbecombinedtocutthetotaltreatmentcostinanactualtreatmentprocess.

简介：重金属包含pickling污泥(PS)是纯洁链钢的工业的副产品之一，它由于包含的铬和镍被认为危险。处理的PS的传统的方法是垃圾堆和水泥团结。这研究针对由团结/稳定处理PS并且作为glassceramics的一个成核代理人再使用它。结晶化行为和在CaOMgOSiO2艾尔2O3系统被把PS看作成核代理人学习。试验性的结果证实那介绍14?glassceramics的成核代理人能减少的wt%PS在110.8的结晶化温度?渠扯摯?猤映潯吗？

简介：Age-relatedhearingloss(AHL),orpresbycusis,isthemostcommonneurodegenerativedisorderandtopcommunicationdeficitoftheagedpopulation.GeneticpredispositionisoneofthemajorfactorsinthedevelopmentofAHL.Generally,AHLisassociatedwithanage-dependentlossofsensoryhaircells,spiralganglionneuronsandstriavasculariscellsintheinnerear.Althoughthemechanismsleadingtogenetichearinglossarenotcompletelyunderstood,caspase-familyproteasesfunctionasimportantsignalsintheinnerearpathology.ItisnowacceptedthatmousemodelsarethebesttoolstostudythemechanismofgenetichearinglossorAHL.Here,weprovideabriefreviewofrecentstudiesonhearingimprovementinmousemodelsofAHLbyanti-apoptotictreatment.

简介：AIMTo为Snellen和早治疗糖尿病的Retinopathy学习(ETDRS)图表比较精确性，重制度和测试持续时间，二个主要工具过去常测量视觉尖酸(VA).METHODSA计算机模拟被规划运用多重虚拟病人，有分配参数的一个唯一的集合的各个，包括VA，假积极、假否定的错误珍视。为各个，虚拟耐心的、分配VA随机沿着跨越在1.0～0.0个logMAR单位(到到20/20的20/200的等价物)之间的范围的连续规模被选择。每30000个虚拟病人在每二VAcharts.RESULTSAverage测试持续时间上被运用十次(表示了为在测试±期间介绍的人物的全部的数字；SD)是12.6±；11.1和31.2±；14.7个人物为Snellen和ETDRS，分别地。精确性，定义为绝对差别(±；SD)在分配VA和测量VA之间，在logMAR表示了单位，在ETDRS图表是优异的：0.12±；0.14和0.08±；0.08为Snellen和ETDRS图表，分别地。重制度，表示了可变性为测试网，在ETDRS图表是优异的：0.23±；0.17和0.11±；0.09个logMAR单位为Snellen和ETDRS图表，respectively.CONCLUSIONA比较真(分配)VA到测量VA，平均，更好证明ETDRS的精确性和重制度制图，但是在显著地更长的测试持续时间的惩罚。这些差别最在低VA范围被读。用一条模拟途径的重制度与在几临床的研究发现的重制度价值一致。